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排序方式: 共有143条查询结果,搜索用时 15 毫秒
1.
V. V. Raevsky L. I. Alexandrov A. D. Vorobyeva T. B. Golubeva E. V. Korneeva I. E. Kudriashov I. V. Kudriashova M. L. Pigareva E. Yu. Sitnikova I. S. Stashkevitch 《Neuroscience and behavioral physiology》1997,27(4):455-461
On the basis of their own data the authors postulate that the increase in sensory input during early ontogeny results in a
delay in the development of the sensory systems formed earlier. In connection with this, the sensory basis of behavioral patterns
becomes ineffective, causing their reorganization and the appearance of new forms of behavior. Limitation of sensory input
during the critical periods of development stimulates the accelerated manifestation of behavioral patterns. However, this
acceleration also has long-lasting negative effects— alterations in the processes of learning and memory in adult animals.
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow. Translated from Zhurnal Vysshei
Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 47, No. 2, pp. 299–307, March–April, 1997. 相似文献
2.
Polontchouk LO Valiunas V Haefliger JA Eppenberger HM Weingart R 《Pflügers Archiv : European journal of physiology》2002,443(5-6):676-689
Gap junctions were assayed during re-differentiation of adult rat cardiomyocytes in long-term culture to gain insight into the processes of remodeling. Double immunostaining allowed the localization of connexins Cx40, Cx43, and Cx45 between myocytes and demonstrated co-expression and co-localization in individual cells and gap junction plaques, respectively. Immunoblots showed differential time-dependent changes in connexin expression and phosphorylation. The total amount of connexins and the ratio of phosphorylated/non-phosphorylated isoforms gradually increased during the re-establishment of intercellular communication. Dual voltage-clamp studies showed the involvement of several types of gap junction channels. Multichannel currents yielded diverse spectra of g(j,inst)=f( V(j)) and g(j,ss)=f( V(j)) relationships ( g(j,inst): instantaneous gap junction conductance; g(j,ss): conductance at steady state; V(j): transjunctional voltage), indicative of homotypic and heterotypic channels. Single-channel currents revealed two prominent conductances reflecting gamma(j,main) and gamma(j,residual). The histograms of gamma(j,main) showed four discrete peaks (41-44, 59-61, 70-76, and 100-107 pS) attributable to a combination of Cx45-Cx45, Cx40-Cx45 and Cx43-Cx45 channels (1st peak), Cx43-Cx43 and Cx40-Cx43 channels (2nd peak), Cx43-Cx43 channels (3rd peak) and Cx40-Cx40 and Cx40-Cx43 channels (4th peak). However, the presence of heteromeric channels cannot be excluded. The data are consistent with an up-regulation of Cx45 and Cx43 during re-differentiation. 相似文献
3.
Svetlana A. Romanenko Natalia A. Sitnikova Natalya A. Serdukova Polina L. Perelman Nadezhda V. Rubtsova Irina Yu. Bakloushinskaya Elena A. Lyapunova Walter Just Malcolm A. Ferguson-Smith Fengtang Yang Alexander S. Graphodatsky 《Chromosome research》2007,15(7):891-897
Using cross-species chromosome painting, we have carried out a comprehensive comparison of the karyotypes of two Ellobius species with unusual sex determination systems: the Transcaucasian mole vole, Ellobius lutescens (2n = 17, X in both sexes), and the northern mole vole, Ellobius talpinus (2n = 54, XX in both sexes). Both Ellobius species have highly rearranged karyotypes. The chromosomal paints from the field vole (Microtus agrestis) detected, in total, 34 and 32 homologous autosomal regions in E. lutescens and E. talpinus karyotypes, respectively. No difference in hybridization pattern of the X paint (as well as Y paint) probes on male and female
chromosomes was discovered. The set of golden hamster (Mesocricetus auratus) chromosomal painting probes revealed 44 and 43 homologous autosomal regions in E. lutescens and E. talpinus karyotypes, respectively. A comparative chromosome map was established based on the results of cross-species chromosome painting
and a hypothetical ancestral Ellobius karyotype was reconstructed. A considerable number of rearrangements were detected; 31 and 7 fusion/fission rearrangements
differentiated the karyotypes of E. lutescens and E. talpinus from the ancestral Ellobius karyotype. It seems that inversions have played a minor role in the genome evolution of these Ellobius species. 相似文献
4.
A N Kabanov K K Kozlov I I Kotov A M Gal'perin A A Kabanov L D Kosterina V M Sitnikova 《Grudnaia i serdechno-sosudistaia khirurgiia / Ministerstvo zdravookhraneniia SSSR [i] Vsesoiuznoe nauchnoe obshchestvo khirurgov》1991,(11):47-51
A new method for treating acute pneumothorax with a bronchopleural fistula was experimentally developed and clinically tested. It is based on thoracoscopic use of CO2 laser radiation. The laser beam energy is employed for evaporation of necrotic tissues in the area of pulmonary destruction, "welding" of the bronchopulmonary fistulae, and general irradiation of the empyema cavity with a defocused beam. Nineteen patients with various disease duration were treated. In 16 patients the bronchial fistulae and the empyema cavity were eliminated and the lung re-expanded. The purulent inflammation in the pleural cavity was acute in these cases. 相似文献
5.
Bree A Schlerman FJ Wadanoli M Tchistiakova L Marquette K Tan XY Jacobson BA Widom A Cook TA Wood N Vunnum S Krykbaev R Xu X Donaldson DD Goldman SJ Sypek J Kasaian MT 《The Journal of allergy and clinical immunology》2007,119(5):1251-1257
BACKGROUND: Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer of airway inflammation in rodent models of respiratory disease, but a role for IL-13 has not been demonstrated in primates. OBJECTIVE: We sought to test the efficacy of a neutralizing antibody to human IL-13 in a cynomolgus monkey model of lung inflammation. METHODS: Using cynomolgus monkeys (Macaca fascicularis) that are sensitized to Ascaris suum through natural exposure, we developed a reproducible model of acute airway inflammation after segmental A suum antigen challenge. This model was used to test the in vivo efficacy of mAb13.2, a mouse mAb directed against human IL-13, and IMA-638, the humanized counterpart of mAb13.2. Bronchoalveolar lavage (BAL) cells and BAL fluid were collected before and after antigen challenge and assayed for cellular content by means of differential count. RESULTS: Total BAL cell count, eosinophil number, and neutrophil number were all reduced in animals treated with mAb13.2 or IMA-638 compared with values in control animals that were untreated, given saline, or treated with human IgG of irrelevant specificity. In addition, levels of eotaxin and RANTES in BAL fluid were reduced in anti-IL-13-treated animals compared with levels seen in control animals. CONCLUSION: These findings support a role for IL-13 in maintaining lung inflammation in response to allergen challenge in nonhuman primates. CLINICAL IMPLICATIONS: IL-13 neutralization with a specific antibody could be a useful therapeutic strategy for asthma. 相似文献
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Sitnikova EY 《Neuroscience and behavioral physiology》2001,31(2):153-156
Neuroscience and Behavioral Physiology - 相似文献
10.
Sitnikova MIu Bol'shakova OO Brodskaia IS Kozlova SN Krutikov AN Shliakhto EV 《Terapevticheski? arkhiv》2001,73(1):46-49
AIM: To assess clinical response to carvedilol in long-term treatment of cardiac failure (CF). MATERIAL AND METHODS: 34 patients with CF (NYHA functional class III-IV) were observed for 6 months. 25 of them received standard therapy combined with carvedilol, 9 patients received only standard therapy. RESULTS: Carvedilol produced positive changes in the disease functional class, left ventricular ejection fraction, stabilisation of echo-CG parameters and cardiothoracic index, resulted in prolongation of 6-min walk distance. Discontinuation of carvedilol therapy enhances CF symptoms. CONCLUSION: Long-term therapy with carvedilol inhibits CF progression. 相似文献