全文获取类型
收费全文 | 583篇 |
免费 | 43篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 20篇 |
基础医学 | 53篇 |
口腔科学 | 62篇 |
临床医学 | 42篇 |
内科学 | 100篇 |
皮肤病学 | 8篇 |
神经病学 | 51篇 |
特种医学 | 64篇 |
外科学 | 58篇 |
综合类 | 6篇 |
预防医学 | 42篇 |
眼科学 | 13篇 |
药学 | 35篇 |
肿瘤学 | 72篇 |
出版年
2021年 | 10篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 5篇 |
2016年 | 6篇 |
2015年 | 15篇 |
2014年 | 7篇 |
2013年 | 22篇 |
2012年 | 14篇 |
2011年 | 20篇 |
2010年 | 14篇 |
2009年 | 21篇 |
2008年 | 20篇 |
2007年 | 15篇 |
2006年 | 16篇 |
2005年 | 15篇 |
2004年 | 16篇 |
2003年 | 25篇 |
2002年 | 29篇 |
2001年 | 11篇 |
2000年 | 25篇 |
1999年 | 19篇 |
1998年 | 17篇 |
1997年 | 14篇 |
1996年 | 11篇 |
1995年 | 14篇 |
1994年 | 18篇 |
1993年 | 10篇 |
1992年 | 11篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 17篇 |
1984年 | 20篇 |
1983年 | 7篇 |
1982年 | 10篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1972年 | 3篇 |
1967年 | 3篇 |
1962年 | 3篇 |
1942年 | 6篇 |
1932年 | 3篇 |
排序方式: 共有628条查询结果,搜索用时 15 毫秒
1.
2.
Robert C. Flanigan Joseph H. Saiers Michael Wolf Eric H. Kraut Anthony Y. Smith Brent Blumenstein E. David Crawford 《Investigational new drugs》1994,12(2):147-149
Summary The Southwest Oncology Group (SWOG) studied the response rate and toxicity of merbarone (1,000 mg/m2 IV continuous infusion days 1–5, q 21 days) in patients with advanced metastatic renal cell carcinoma. Among 36 eligible patients, there was one partial response for a response rate of 3% (95% C.I. 0.1–15%). There were no mixed responses. There were no treatment related deaths or adverse drug reactions. Significant anemia, diarrhea, and hypercalcemia were observed. Mild to moderate degrees of malaise/fatigue/lethargy, dizziness/vertigo, hyperglycemia, creatinine increase, nausea, vomiting, weight loss, pedal edema, dyspnea, and granulocytopenia were noted. Merbarone does not have significant activity as a single agent in advanced renal cell carcinoma. 相似文献
3.
B G Redman L Flaherty S Martino M Kraut C Wisniewski M Valdivieso J J Bander 《American journal of clinical oncology》1992,15(4):340-343
Administration of high-dose IL-2 results in hemodynamic changes that are similar to those seen in septic shock. These include a decrease in systemic vascular resistance (SVR) with a resultant drop in mean arterial pressure (MAP). Hypocalcemia is seen in septic shock and with IL-2 administration. Calcium replacement in septic shock has been reported to result in hemodynamic improvement; we therefore administered calcium to patients receiving high dose IL-2 to correct ionized hypocalcemia. Five consecutive patients underwent invasive hemodynamic monitoring before and during IL-2 administration. Calcium chloride was administered to correct ionized hypocalcemia, and hemodynamic parameters were monitored before and after calcium administration. Ionized hypocalcemia was associated with an elevation in parathyroid hormone levels. There was no toxicity related to the administration of calcium. An improvement in the MAP and SVR was seen early and late (after a dose of IL-2 was held) in the IL-2 treatment cycle; there were minimal effects at other points. Because of the potential hemodynamic benefit of calcium replacement, we recommend that ionized hypocalcemia be corrected in patients receiving high-dose IL-2. 相似文献
4.
Sequential contrast-enhanced MR imaging of the penis 总被引:1,自引:0,他引:1
5.
A cation binding motif stabilizes the compound I radical of cytochrome c peroxidase. 总被引:1,自引:0,他引:1 下载免费PDF全文
M A Miller G W Han J Kraut 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(23):11118-11122
Cytochrome c peroxidase reacts with peroxide to form compound I, which contains an oxyferryl heme and an indolyl radical at Trp-191. The indolyl free radical has a half-life of several hours at room temperature, and this remarkable stability is essential for the catalytic function of cytochrome c peroxidase. To probe the protein environment that stabilizes the compound I radical, we used site-directed mutagenesis to replace Trp-191 with Gly or Gln. Crystal structures of these mutants revealed a monovalent cation binding site in the cavity formerly occupied by the side chain of Trp-191. Comparison of this site with those found in other known cation binding enzymes shows that the Trp-191 side chain resides in a consensus K+ binding site. Electrostatic potential calculations indicate that the cation binding site is created by partial negative charges at the backbone carbonyl oxygen atoms of residues 175 and 177, the carboxyl end of a long alpha-helix (residues 165-175), the heme propionates, and the carboxylate side chain of Asp-235. These features create a negative potential that envelops the side chain of Trp-191; the calculated free energy change for cation binding in this site is -27 kcal/mol (1 cal = 4.184J). This is more than sufficient to account for the stability of the Trp-191 radical, which our estimates suggest is stabilized by 7.8 kcal/mol relative to a Trp radical in solution. 相似文献
6.
Genotype-phenotype correlation for nucleotide substitutions in the IgII- IgIII linker of FGFR2 总被引:6,自引:3,他引:3
7.
John Hart Raksha Anand Sandra Zoccoli Mandy Maguire Jacque Gamino Gail Tillman Richard King Michael A Kraut 《Journal of the International Neuropsychological Society》2007,13(5):865-880
Semantic memory is described as the storage of knowledge, concepts, and information that is common and relatively consistent across individuals (e.g., memory of what is a cup). These memories are stored in multiple sensorimotor modalities and cognitive systems throughout the brain (e.g., how a cup is held and manipulated, the texture of a cup's surface, its shape, its function, that is related to beverages such as coffee, and so on). Our ability to engage in purposeful interactions with our environment is dependent on the ability to understand the meaning and significance of the objects and actions around us that are stored in semantic memory. Theories of the neural basis of the semantic memory of objects have produced sophisticated models that have incorporated to varying degrees the results of cognitive and neural investigations. The models are grouped into those that are (1) cognitive models, where the neural data are used to reveal dissociations in semantic memory after a brain lesion occurs; (2) models that incorporate both cognitive and neuroanatomical information; and (3) models that use cognitive, neuroanatomic, and neurophysiological data. This review highlights the advances and issues that have emerged from these models and points to future directions that provide opportunities to extend these models. The models of object memory generally describe how category and/or feature representations encode for object memory, and the semantic operations engaged in object processing. The incorporation of data derived from multiple modalities of investigation can lead to detailed neural specifications of semantic memory organization. The addition of neurophysiological data can potentially provide further elaboration of models to include semantic neural mechanisms. Future directions should incorporate available and newly developed techniques to better inform the neural underpinning of semantic memory models. 相似文献
8.
Horne G; Jamaludin A; Critchlow JD; Falconer DA; Newman MC; Oghoetuoma J; Pease EH; Lieberman BA 《Human reproduction (Oxford, England)》1998,13(11):3045-3048
Insemination with donor spermatozoa is an integral part of infertility
treatment. For the last 3 years in our unit, intrauterine insemination with
donor spermatozoa (IUID) has been used in preference to vaginal
insemination. In this retrospective study, patients were offered an initial
course of five single intrauterine inseminations with cryopreserved donor
spermatozoa and treatment was then reviewed. A total of 389 patients
received 1465 inseminations. In all, 1119 cycles were monitored using
luteinizing hormone serum analyses and 346 cycles using the urine home test
kits. The clinical pregnancy rate per insemination for the cycles monitored
by the serum assay was 18.0% (202/1119) compared with the urine cycles
(13.7%, 46/346) (P <05). The pregnancy loss rate was not significantly
different (14.4%, 29/202 and 21.7%, 10/46) (serum and urine cycles
respectively). The viable clinical pregnancy rate was significantly higher
(P <03) for the serum cycles than for the cycles using the urinary
monitoring (15.5%, 173/1119 and 10.4%, 36/346 respectively). The cycles
monitored by serum assay had a significantly higher cumulative viable
clinical pregnancy rate (P <0001) of 70.2% after nine inseminations
compared with the urine monitored cycles of 54.8%. The majority of patients
opted for the serum cycles, with a minority self-selecting the urine cycles
mainly for travelling convenience. The explanation for the significant
differences between the viable clinical pregnancy rates per insemination
and the cumulative viable clinical pregnancy rates may be due to the
sensitivity of the urine home test kit or the patients' interpretation of
the result.
相似文献
9.
Ohne Zusammenfassung 相似文献
10.