Clinical picture, dynamics and treatment of reactive depressions in infant.

The authors studied the typology, clinical picture, dynamics and therapy of reactive (psychogenic) depressions in 46 children, aged 1.5-4.5 years. Clinical-psychopathological variants of depression and types of dynamics have been described, which is important for prognosis and choice of adequate therapy.     

Dietary polyamines promote the growth of azoxymethane-induced aberrant crypt foci in rat colon

We have examined whether dietary polyamines influence the formation and initial growth of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in rat colon. Effects of a combination of dietary polyamines at three dose levels (putrescine: 50, 280, 740 nmol/g; spermidine: 10, 261, 763 nmol/g; spermine: 1, 31, 91 nmol/g) in the polyamine-poor AIN-76A diet were studied in animals in two different experimental situations: animals treated with AOM alone and animals treated with AOM + difluoromethylornithine (DFMO), a specific inhibitor of endogenous polyamine synthesis. In both experimental situations, dietary polyamines enhanced the growth of ACF, expressed as the number of large ACF (foci with three or more aberrant crypts, ACF > or = 3), whereas the formation of ACF, expressed as the number of ACF, was apparently not altered. In animals treated with AOM alone, maximal growth enhancing effect on ACF was nearly obtained with the median level of dietary polyamine. In rats fed a low polyamine diet, basic AIN-76A, DFMO reduced the growth of AOM-induced ACF by 83%. This inhibitory effect of DFMO was counteracted by dietary polyamines in a dose- dependent manner, and it was abolished at the highest level of polyamines. In conclusion, it was demonstrated that dietary polyamines are able to enhance the growth of AOM-induced ACF. Further, dietary polyamines reversed the DFMO-caused inhibition of ACF growth, probably by compensating for the DFMO-reduced endogenous polyamine synthesis.      

Influence of Common Tansy (Tanacetum vulgare) Flower Polysaccharide Complex on P-Glycoprotein Transporter Activity in Vitro

Pharmaceutical Chemistry Journal - The influence of the common tansy (Tanacetum vulgare) flower polysaccharide complex on P-glycoprotein (Pgp, ABCB1-protein) activity in Caco-2 cell line was...     

Perioperative Outcomes of Melanoma Patients Undergoing Surgery After Receiving Immunotherapy or Targeted Therapy

World Journal of Surgery - Traditional chemotherapy agents adversely affect wound healing and need to be held prior to or after surgery. Immune checkpoint inhibitors (ICIs) and targeted agents are...     

A method for determination of the effective dose received by patient during digital scanning fluorographic examination from the results of measurement of radiation dose scattered by patient's body

An original method for determination of the effective dose received by patient during digital scanning fluorographic examination from the results of measurement of radiation dose scattered by patient's body was suggested. This method does not require radiation detector to be exposed to working field. This method of determination of the effective dose of radiation scattered by patient's body can be used in scanning radiography.