全文获取类型
收费全文 | 11173篇 |
免费 | 548篇 |
国内免费 | 115篇 |
专业分类
耳鼻咽喉 | 114篇 |
儿科学 | 244篇 |
妇产科学 | 232篇 |
基础医学 | 1363篇 |
口腔科学 | 368篇 |
临床医学 | 741篇 |
内科学 | 2818篇 |
皮肤病学 | 261篇 |
神经病学 | 689篇 |
特种医学 | 646篇 |
外科学 | 1904篇 |
综合类 | 25篇 |
一般理论 | 1篇 |
预防医学 | 350篇 |
眼科学 | 148篇 |
药学 | 679篇 |
中国医学 | 24篇 |
肿瘤学 | 1229篇 |
出版年
2023年 | 49篇 |
2022年 | 93篇 |
2021年 | 206篇 |
2020年 | 137篇 |
2019年 | 188篇 |
2018年 | 232篇 |
2017年 | 184篇 |
2016年 | 214篇 |
2015年 | 239篇 |
2014年 | 334篇 |
2013年 | 389篇 |
2012年 | 579篇 |
2011年 | 627篇 |
2010年 | 357篇 |
2009年 | 290篇 |
2008年 | 590篇 |
2007年 | 664篇 |
2006年 | 605篇 |
2005年 | 633篇 |
2004年 | 557篇 |
2003年 | 610篇 |
2002年 | 584篇 |
2001年 | 305篇 |
2000年 | 280篇 |
1999年 | 265篇 |
1998年 | 157篇 |
1997年 | 106篇 |
1996年 | 119篇 |
1995年 | 78篇 |
1994年 | 100篇 |
1993年 | 68篇 |
1992年 | 197篇 |
1991年 | 163篇 |
1990年 | 158篇 |
1989年 | 162篇 |
1988年 | 124篇 |
1987年 | 134篇 |
1986年 | 126篇 |
1985年 | 108篇 |
1984年 | 81篇 |
1983年 | 63篇 |
1982年 | 51篇 |
1981年 | 41篇 |
1979年 | 86篇 |
1978年 | 55篇 |
1977年 | 47篇 |
1975年 | 34篇 |
1974年 | 34篇 |
1973年 | 33篇 |
1969年 | 37篇 |
排序方式: 共有10000条查询结果,搜索用时 265 毫秒
1.
Heterozygous nonsense mutations near the C‐terminal region of IGF1R in two patients with small‐for‐gestational‐age‐related short stature
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
3.
Akira Sugawara Kazuhisa Takeuchi Takashi Suzuki Keiichi Itoi Hironobu Sasano Sadayoshi Ito 《Hypertension research》2003,26(8):663-668
We describe a case of aldosterone-producing adrenocortical adenoma (APA) associated with a probable post-operative adrenal crisis possibly due to subtle autonomous cortisol secretion. The patient was a 46-year-old female who suffered from severe hypertension and hypokalemia. CT and MRI scans revealed a 2-cm diameter adrenal mass. The patient's plasma aldosterone level was increased, and her plasma renin activity was suppressed, both of which findings were consistent with APA. Cushingoid appearance was not observed. Morning and midnight serum cortisol and plasma adrenocorticotropic hormone (ACTH) levels were all within the normal range. Her serum cortisol level was suppressed to 1.9 microg/dl as measured by an overnight 1-mg dexamethasone suppression test, but was incompletely suppressed (2.7 microg/dl) by an overnight 8-mg dexamethasone suppression test. In addition, adrenocortical scintigraphy showed a strong uptake at the tumor region and a complete suppression of the contra-lateral adrenal uptake. After unilateral adrenalectomy, she had an episode of adrenal crisis, and a transient glucocorticoid replacement improved the symptoms. Histopathological studies demonstrated that the tumor was basically compatible with APA. The clear cells in the tumor were admixed with small numbers of compact cells that expressed 17alpha-hydroxylase, suggesting that the tumor was able to produce and secrete cortisol. In addition, the adjacent non-neoplastic adrenal cortex showed cortical atrophy, and dehydroepiandrosterone sulfotransferase immunoreactivity in the zonae fasciculata and reticularis was markedly diminished, suggesting that the hypothalamo-pituitary-adrenal (HPA) axis of the patient was suppressed due to neoplastic production and secretion of cortisol. Together, these findings suggested that autonomous secretion of cortisol from the tumor suppressed the HPA axis of the patient, thereby triggering the probable post-operative adrenal crisis. Post-operative adrenocortical insufficiency should be considered in clinical management of patients with relatively large APA, even when physical signs of autonomous cortisol overproduction are not apparent. 相似文献
4.
Takako Miyamae Masaaki Mori Yasuji Inamo Youichi Kohno Shuji Takei Motoharu Maeda Takuji Murata Shuji Nakata Hiroshi Kawai Yukiko Hirano Yukiji Date Katsuhiko Kitamura Shumpei Yokota 《Ryūmachi》2003,43(3):538-543
OBJECTIVES: To reveal the frequency and the clinical characteristics of dystrophic calcification that occurs in children with juvenile dermatomyositis, multi-center analysis was constructed. METHOD: Fifty children with JDM were enrolled, and 14 of them (28.0%) were complicated with calcinosis. Clinical symptoms and laboratory tests at onset, initial therapy and disease course were compared in children with and without calcinosis. RESULTS: The mean age of the onset of calcinosis was 4.78 +/- 3.33 years, and it was younger than those of children without calcinosis (8.66 +/- 3.85 years) (P = 0.0017). No differences of clinical manifestation except Gower's sign were observed. The frequency of positive anti-nuclear antibody was 7.1% in children with calcinosis and 52.9% without calcinosis (P = 0.0112). The initial therapy of methylprednisolon pulses gave no effects on prognosis of calcium deposition. The calcinosis appeared in 1.56 +/- 1.91 year after the onset of the disease. The various types of calcium deposition including large tumorous clumps, subcutaneous plaques or nodules, sheet-type calcification were deserved. They appeared over knee joints (64.3%), elbow joint (64.3%), and hip processes (50.0%). Calcinosis affecting the subcutaneous tissues frequently resulted in painful superficial ulceration of the overlying skin (42.9%), local infection (50.0%), and limitation of joint movement (14.3%). Although aluminum phosphate was effective in 2 children among 7, no other effective treatment was recommended. In 5 cases, surgical removal of tumorous clumps was operated. Thus, juvenile dermatomyositis is frequently complicated with calcinosis. This type of calcinosis was found to be unlikely to resolve completely, and resulted in severe disability in children. 相似文献
5.
6.
K Murata H Itoh G Todo T Itoh M Kanaoka M Furuta K Torizuka 《Investigative radiology》1986,21(1):24-30
This study was undertaken to clarify the microvascular anatomy of the normal human bronchial circulation, focusing on the bronchial venous system and its communication with the pulmonary circulation. Ten normal lungs obtained at autopsy were studied. Bronchial arteriography was performed in six lungs, pulmonary arteriography in two lungs, and pulmonary venography in another two. Using radiologic methods, including microradiography, and serial histologic sections, we found numerous bronchial venous plexuses around the airways and blood vessels into which the bronchial capillaries drained. Frequent communications of the venous plexuses with the pulmonary veins and neighboring alveolar capillaries were also demonstrated. The bronchial venous plexus and its close connection with the pulmonary circulation may be important in various pathologic conditions involving the interstitial space, such as interstitial pulmonary edema. 相似文献
7.
Changes in central dopaminergic systems with the expression of Shh or GDNF in mice perinatally exposed to bisphenol-A. 总被引:1,自引:0,他引:1
Kazuya Miyagawa Minoru Narita Michiko Narita Keiichi Niikura Hisahiko Akama Yuri Tsurukawa Tsutomu Suzuki 《Nihon shinkei seishin yakurigaku zasshi》2007,27(2):69-75
In the previous study, we reported that exposure to bisphenol-A induced the potentiation of dopamine receptor functions in the mouse limbic area, resulting in supersensitivity to methamphetamine-induced pharmacological actions. The present study was undertaken to investigate whether prenatal exposure to bisphenol-A could produce morphological change in dopaminergic neuron and the pattern of expression of genes regulating the dopaminergic neuron development. Here we found that prenatal and neonatal exposures to bisphenol-A increased the tyrosine hydroxylase- and dopamine transporter-like immunoreactivities in the adult mouse limbic area. The present molecular biological study shows that chronic bisphenol-A treatment produced a significant decrease in the dopaminergic neuron development factors, sonic hedgehog and glial cell line-derived neurotrophic factor, which were also decreased by prenatal exposure to bisphenol-A. These results suggest that chronic exposure to bisphenol-A could disrupt the dopaminergic neurotransmission in the process of dopaminergic neuron development. 相似文献
8.
9.
Yoichiro Hosokawa D.D.S. D.D.Sc. Kazuyuki Minowa D.D.S. Satoru Abe M.D. Keiichi Ohmori D.D.S. D.D.Sc. Michio Yamasaki M.D. D.M.Sc. Masanobu Shindoh D.D.S. D.D.Sc. Tadashi Iizuka D.D.S. D.D.Sc. Mohiuddin Ahmed B.D.S. Akira Amemiya D.D.S. D.D.Sc. 《Oral Radiology》1991,7(1):1-6
A case of an odontogenic tumor which invaded the intracranial space from the mandible is reported. Judging from the radiographic
images it was similar to a malignant tumor. The patient died 17 years after the first visit. According to the final pathological
diagnosis, it was malignant odontogenic mixed tumor of low grade which did not belong to any of the WHO classification. 相似文献
10.
Staging of esophageal carcinoma in vitro with 4.7-T MR imaging 总被引:4,自引:0,他引:4