全文获取类型
收费全文 | 10509篇 |
免费 | 459篇 |
国内免费 | 132篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 183篇 |
妇产科学 | 73篇 |
基础医学 | 1143篇 |
口腔科学 | 270篇 |
临床医学 | 660篇 |
内科学 | 2951篇 |
皮肤病学 | 145篇 |
神经病学 | 706篇 |
特种医学 | 450篇 |
外科学 | 2181篇 |
综合类 | 42篇 |
预防医学 | 231篇 |
眼科学 | 122篇 |
药学 | 574篇 |
中国医学 | 15篇 |
肿瘤学 | 1267篇 |
出版年
2024年 | 8篇 |
2023年 | 82篇 |
2022年 | 147篇 |
2021年 | 288篇 |
2020年 | 164篇 |
2019年 | 178篇 |
2018年 | 233篇 |
2017年 | 188篇 |
2016年 | 254篇 |
2015年 | 250篇 |
2014年 | 367篇 |
2013年 | 459篇 |
2012年 | 693篇 |
2011年 | 737篇 |
2010年 | 397篇 |
2009年 | 360篇 |
2008年 | 657篇 |
2007年 | 671篇 |
2006年 | 670篇 |
2005年 | 739篇 |
2004年 | 705篇 |
2003年 | 658篇 |
2002年 | 638篇 |
2001年 | 132篇 |
2000年 | 105篇 |
1999年 | 146篇 |
1998年 | 173篇 |
1997年 | 124篇 |
1996年 | 116篇 |
1995年 | 86篇 |
1994年 | 76篇 |
1993年 | 77篇 |
1992年 | 69篇 |
1991年 | 73篇 |
1990年 | 55篇 |
1989年 | 58篇 |
1988年 | 38篇 |
1987年 | 37篇 |
1986年 | 34篇 |
1985年 | 33篇 |
1984年 | 20篇 |
1983年 | 19篇 |
1982年 | 8篇 |
1981年 | 12篇 |
1980年 | 7篇 |
1979年 | 10篇 |
1978年 | 8篇 |
1977年 | 5篇 |
1975年 | 6篇 |
1973年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Comparative safety study on severe anemia by simeprevir versus telaprevir‐based triple therapy for chronic hepatitis C 下载免费PDF全文
Eiichi Ogawa Norihiro Furusyo Eiji Kajiwara Hideyuki Nomura Akira Kawano Kazuhiro Takahashi Kazufumi Dohmen Takeaki Satoh Koichi Azuma Makoto Nakamuta Toshimasa Koyanagi Kazuhiro Kotoh Shinji Shimoda Jun Hayashi The Kyushu University Liver Disease Study Group 《Journal of gastroenterology and hepatology》2015,30(8):1309-1316
6.
Shoji Kubo Hiroaki Kinoshita Kazuhiro Hirohashi Takatsugu Yamamoto 《Journal of Hepato-Biliary-Pancreatic Surgery》1995,2(1):85-89
A case of cystadenocarcinoma of the liver is reported. The patient was a 73-year-old woman in whom a tumor was detected in
the lateral segment of the liver during a health examination. Ultrasonograms and computed tomograms showed a multilocular
cystic mass. Magnetic resonance imaging (MRI) showed a multilocular lowintensity mass, including a high-intensity portion
and a portal branch compressed by the tumor. MRI with gadolinium showed an enhanced cyst wall. The cystic part of the tumor
became smaller and the solid part became larger over a 1-month period, indicating that the tumor was malignant. Subsegmentectomy
(S3) was performed and cystadenocarcinoma with cystadenoma was diagnosed by histopathological examination. Identification of
changes in the appearance of a tumor should be helpful for the differential diagnosis of cystadenoma and cystadenocarcinoma. 相似文献
7.
Severe myoclonic epilepsy (SMEI) or Dravet syndrome is caused by mutations of the SCN1A gene that encodes voltage-gated sodium channel alpha-1 subunit. Recently, we generated and characterized a knock-in (KI) mice with an SCN1A nonsense mutation that appeared in three independent SMEI patients. The SCN1A-KI mice well reproduced the SMEI disease phenotypes. Both homozygous and heterozygous knock-in mice developed epileptic seizures within the first postnatal month. In heterozygous knock-in mice, trains of evoked action potentials in inhibitory neurons exhibited pronounced spike amplitude decrement late in the burst but not in pyramidal neurons. We further showed that in wild-type mice the Nav1.1 protein is expressed dominantly in axons and moderately in somata of parbalbumin (PV) – positive inhibitory interneurons. Our immunohistochemical observations of the Nav1.1 are clearly distinct to the previous studies, and our findings has corrected the view of the Nav1.1 protein distribution. The data indicate that Nav1.1 plays critical roles in the spike output from PV interneurons and further, that the specifically altered function of these inhibitory circuits may contribute to epileptic seizures in the mice. These information should contribute to the understanding of molecular pathomechanism of SMEI and to develop its effective therapies. 相似文献
8.
Tatsurou Tanaka Yasuhiro Morimoto Hiroshi Takano Kazuhiro Tominaga Shinji Kito Sachiko Okabe Tetsu Takahashi Jin-ichi Fukuda Takeshi Ohba 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(5):609-613
OBJECTIVE: To evaluate a proposed technique for the 3-dimensional (3D) detection of hemangiomas, including vascular malformation and their feeding arteries, in the head and neck. The new technique combines phase-contrast magnetic resonance angiography (PCMRA) without contrast medium and 3D fast asymmetric spin-echo (FASE) sequences. METHODS: The technique was applied to 3 patients having hemangiomas in the head and neck region. In 1 patient the image obtained with the proposed technique was compared to that obtained by standard contrast angiography. RESULTS: In all 3 patients, the 3D presence of the hemangiomas and the feeding arteries were well defined in images created by the proposed technique. Additionally, the characterization of the hemangioma's 3D structure and distribution of the feeding arteries coincided with those observed using contrast angiography in the case for which contrast angiography was also performed. CONCLUSIONS: Preliminary experience shows that the proposed technique combining 3D-FASE and 3D-PCMRA is useful to visualize both the 3D structure of hemangiomas and to identify the 3D distribution of the feeding arteries without using contrast medium. 相似文献
9.
Hiroki Otani Yutaka Kagaya Yoshio Imahori Satoshi Yasuda Ryo Fujii Masanobu Chida Shigeto Namiuchi Morihiko Takeda Masahito Sakuma Jun Watanabe Tatsuo Ido Hiroshi Nonogi Kunio Shirato 《Journal of nuclear medicine》2005,46(4):553-559
Left ventricular (LV) remodeling after myocardial infarction (MI) is a maladaptive process that increases the risk of heart failure and death. The myocardial phosphoinositide cycle, which is located downstream from several neurohumoral factors, plays a crucial role in LV remodeling. Our animal studies demonstrated that 1-[1-11C]butyryl-2-palmitoyl-rac-glycerol (11C-DAG) can be used to visualize regions with an activated phosphoinositide cycle. Therefore, we examined whether myocardial 11C-DAG accumulation assessed by PET is relevant to LV enlargement and systolic dysfunction in post-MI patients. METHODS: We performed PET with 11C-DAG in 13 post-anteroseptal MI patients and 4 healthy volunteers. We placed regions of interest on the noninfarcted myocardium and calculated the myocardium-to-left atrial (LA) chamber ratio of 11C-DAG accumulation. RESULTS: The myocardium-to-LA chamber ratio of 11C-DAG was significantly higher in the post-MI patients (mean +/- SD, 1.73 +/- 0.35) compared with that of the healthy volunteers (mean +/- SD, 1.25 +/- 0.13; P < 0.05). In the post-MI patients, the myocardium-to-LA chamber ratio of (11)C-DAG was significantly correlated with the LV end-diastolic volume index (r = 0.79, P < 0.01) and the plasma concentration of brain natriuretic peptide (r = 0.85, P < 0.001) and negatively correlated with the LV ejection fraction (r = -0.69, P < 0.01). CONCLUSION: These findings suggest that the myocardial 11C-DAG accumulation assessed by PET is relevant to LV enlargement, LV systolic dysfunction, and humoral activation in post-MI patients. This new imaging strategy based on intracellular signaling may contribute to the assessment and treatment of post-MI patients. 相似文献
10.
Isolated rupture of radial collateral ligament of the small finger DIP joint is a rare injury. We treated this lesion using a bone suture anchor with excellent results. 相似文献