全文获取类型
收费全文 | 754篇 |
免费 | 33篇 |
国内免费 | 5篇 |
专业分类
儿科学 | 14篇 |
妇产科学 | 6篇 |
基础医学 | 100篇 |
口腔科学 | 26篇 |
临床医学 | 54篇 |
内科学 | 116篇 |
皮肤病学 | 6篇 |
神经病学 | 23篇 |
特种医学 | 149篇 |
外科学 | 149篇 |
综合类 | 18篇 |
预防医学 | 57篇 |
眼科学 | 2篇 |
药学 | 32篇 |
肿瘤学 | 40篇 |
出版年
2021年 | 6篇 |
2020年 | 12篇 |
2019年 | 7篇 |
2018年 | 20篇 |
2017年 | 7篇 |
2016年 | 17篇 |
2015年 | 31篇 |
2014年 | 15篇 |
2013年 | 38篇 |
2012年 | 29篇 |
2011年 | 21篇 |
2010年 | 33篇 |
2009年 | 18篇 |
2008年 | 30篇 |
2007年 | 30篇 |
2006年 | 25篇 |
2005年 | 40篇 |
2004年 | 30篇 |
2003年 | 26篇 |
2002年 | 19篇 |
2001年 | 24篇 |
2000年 | 32篇 |
1999年 | 15篇 |
1998年 | 25篇 |
1997年 | 26篇 |
1996年 | 20篇 |
1995年 | 16篇 |
1994年 | 15篇 |
1993年 | 10篇 |
1992年 | 3篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 11篇 |
1988年 | 12篇 |
1987年 | 5篇 |
1986年 | 16篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 9篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1974年 | 3篇 |
1972年 | 3篇 |
1968年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有792条查询结果,搜索用时 15 毫秒
1.
Nienhaus A. Kromark K. Raulf-Heimsoth M. van Kampen V. Merget R. 《Trauma und Berufskrankheit》2007,10(1):75-77
Trauma und Berufskrankheit - Die Vermeidung gepuderter Latexhandschuhe gilt als wichtige Maßnahme zur Prävention von latexbedingten Haut- und Atemwegsallergien bei Beschäftigten im... 相似文献
2.
Edwin H. Preston Jimmy A. Light Robert L. Kampen Allan D. Kirk 《American journal of transplantation》2004,4(2):283-285
Passenger leukocytes have been suggested to be both pro-tolerant and immunogenic. The opportunity to evaluate the role of allogeneic passenger leukocytes in humans was presented by a 47-year-old man who donated bone marrow to his HLA-identical leukemic sister. Eleven years later he developed renal failure. The sister's marrow was noted to be 100% XY karyotype and free of malignancy. She donated a kidney to her brother. Immunosuppression was tapered following transplantation. After 6 months, the recipient was on monotherapy sirolimus, 1 mg every third day. A surveillance biopsy was normal and sirolimus was stopped. Eight weeks later, he presented with severe rejection that reversed with Thymoglobulin. Renal function returned to baseline and has been stable on conventional immunosuppression. 相似文献
3.
A E Koch J Kampen K Tetzlaff M Reuter P McCormack P W Schnoor N Struck L Heine I Prytulla H Rieckert 《Undersea & hyperbaric medicine》2004,31(2):261-268
BACKGROUND: To investigate incidence and number of abnormal cerebral hyperintensities (ACFs) in Magnet Resonance Imaging (MRI) and its relation to a patent foramen ovale (PFO) in divers with no history of decompression illness. METHODS: Cohort study on 50 divers (21-5500 dives). MAIN OUTCOME MEASURES: Incidence and number of ACFs visualized by cranial MRI and presence and size of a PFO as documented by echocardiography and transcranial Doppler ultrasound (TCD) with echocontrast. RESULTS: A total of 137 ACFs was found in the 50 subjects, with a significant correlation between the number of dives and number of ACFs (r = 0.28; p < 0.05); but after correction for age, the remaining correlation (r = 0.15) did not reach significance. In 18 divers, a PFO was present by either the application of echocardiography or TCD; in 12 divers, the PFO was of high hemodynamic relevance. Ten of 18 divers with a PFO had at least one ACF, while in the remaining 32 divers, only 14 had at least one ACF (56% versus 44%, p = NS). Seven of 14 divers (50%) with 4 ACFs had a PFO, compared to 11 of 36 (31%) with less than 4 ACFs (p = NS). CONCLUSION: In this cohort of healthy divers, in contrast to an earlier report, no significant association was found between PFO presence and incidence or number of ACFs. 相似文献
4.
5.
6.
7.
8.
9.
Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability 总被引:1,自引:15,他引:1
La Spada AR; Peterson KR; Meadows SA; McClain ME; Jeng G; Chmelar RS; Haugen HA; Chen K; Singer MJ; Moore D; Trask BJ; Fischbeck KH; Clegg CH; McKnight GS 《Human molecular genetics》1998,7(6):959-967
X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a CAG
repeat expansion in the first exon of the androgen receptor (AR) gene.
Disease-associated alleles (37-66 CAGs) change in length when transmitted
from parents to offspring, with a significantly greater tendency to shift
size when inherited paternally. As transgenic mice carrying human AR cDNAs
with 45 and 66 CAG repeats do not display repeat instability, we attempted
to model trinucleotide repeat instability by generating transgenic mice
with yeast artificial chromosomes (YACs) carrying AR CAG repeat expansions
in their genomic context. Studies of independent lines of AR YAC transgenic
mice with CAG 45 alleles reveal intergenerational instability at an overall
rate of approximately 10%. We also find that the 45 CAG repeat tracts are
significantly more unstable with maternal transmission and as the
transmitting mother ages. Of all the CAG/CTG repeat transgenic mice
produced to date the AR YAC CAG 45 mice are unstable with the smallest
trinucleotide repeat mutations, suggesting that the length threshold for
repeat instability in the mouse may be lowered by including the appropriate
flanking human DNA sequences. By sequence-tagged site content analysis and
long range mapping we determined that one unstable transgenic line has
integrated an approximately 70 kb segment of the AR locus due to
fragmentation of the AR YAC. Identification of the cis - acting elements
that permit CAG tract instability and the trans -acting factors that
modulate repeat instability in the AR YAC CAG 45 mice may provide insights
into the molecular basis of trinucleotide repeat instability in humans.
相似文献
10.
Iliac and sacral articular cartilage of 25 human sacroiliac joints (1–93 years) are examined by light microscopy and immunohistochemistry
in order to gain further insight into the nature and progress of degenerative changes appearing during aging. These changes
can already be seen in younger adults as compared to cartilage degeneration known in other diarthrodial joints. Structural
differences between sacral and iliac cartilage can already be observed in the infant: the sacral auricular facet is covered
with a hyaline articular cartilage, reaching 4 mm in thickness in the adult and staining intensely blue with alcian blue at
pH1. Iliac cartilage of the newborn is composed of a dense fibrillar network of thick collagen bundles, crossing each other
at approximately right angles. A faint staining with alcian blue suggests a low content of acidic glycosaminoglycans. In the
adult, iliac cartilage becomes hyaline and its maximal thickness reaches 1–2 mm. Both articular facets exhibit morphological
changes during aging that are more pronounced in the iliac cartilage and resemble osteoarthritic degeneration; the staining
pattern of the extracellular matrix becomes inhomogenous, chondrocytes are arranged in clusters and the articular surface
develops superficial irregularities and fissures. Sometimes fibrous tissue fills up these defects. Nevertheless, large areas
of iliac cartilage remain hyaline in nature. Sacral articular cartilage often remains largely unaltered until old age. The
sacral subchondral bone plate is usually thin and shows spongiosa trabeculae inserted at right angles, suggesting a perpendicular
load on the articular facet. Iliac subchondral spongiosa shows no definite alignment and joins the thickened subchondral bone
plate in an oblique direction. The iliac cartilage therefore seems to be stressed predominantly by shearing forces, arising
from the changing monopodal support of the pelvis during locomotion. The subchondral bone plate on both the iliac and sacral
auricular facet is penetrated by blood vessels that come into close contact with the overlying articular cartilage. These
vessels may contribute to the high incidence of rheumatoid and inflammatory diseases in the human sacroiliac joint. Immunolabelling
with an antibody against type II collagen reveals a diminished immunoreactivity in the upper half of adult sacral cartilage
and only a faint and irregular labelling in the iliac cartilage. Type I collagen can be detected in a superficial layer on
the sacral articular surface and around chondrocyte clusters in iliac cartilage, as in dedifferentiating chondrocytes during
the development of osteoarthritis.
Accepted: 22 April 1998 相似文献