全文获取类型
收费全文 | 13966篇 |
免费 | 1072篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 169篇 |
儿科学 | 336篇 |
妇产科学 | 155篇 |
基础医学 | 1685篇 |
口腔科学 | 136篇 |
临床医学 | 1584篇 |
内科学 | 3232篇 |
皮肤病学 | 201篇 |
神经病学 | 1259篇 |
特种医学 | 467篇 |
外科学 | 2686篇 |
综合类 | 168篇 |
一般理论 | 16篇 |
预防医学 | 1012篇 |
眼科学 | 293篇 |
药学 | 805篇 |
中国医学 | 11篇 |
肿瘤学 | 861篇 |
出版年
2024年 | 22篇 |
2023年 | 181篇 |
2022年 | 372篇 |
2021年 | 793篇 |
2020年 | 392篇 |
2019年 | 594篇 |
2018年 | 700篇 |
2017年 | 446篇 |
2016年 | 474篇 |
2015年 | 546篇 |
2014年 | 767篇 |
2013年 | 831篇 |
2012年 | 1326篇 |
2011年 | 1310篇 |
2010年 | 676篇 |
2009年 | 555篇 |
2008年 | 919篇 |
2007年 | 853篇 |
2006年 | 713篇 |
2005年 | 618篇 |
2004年 | 537篇 |
2003年 | 461篇 |
2002年 | 357篇 |
2001年 | 44篇 |
2000年 | 36篇 |
1999年 | 41篇 |
1998年 | 48篇 |
1997年 | 35篇 |
1996年 | 32篇 |
1995年 | 20篇 |
1994年 | 18篇 |
1993年 | 25篇 |
1992年 | 16篇 |
1991年 | 20篇 |
1990年 | 17篇 |
1989年 | 21篇 |
1988年 | 16篇 |
1987年 | 18篇 |
1986年 | 17篇 |
1985年 | 23篇 |
1984年 | 13篇 |
1983年 | 8篇 |
1982年 | 17篇 |
1981年 | 19篇 |
1980年 | 16篇 |
1979年 | 23篇 |
1978年 | 18篇 |
1976年 | 13篇 |
1975年 | 6篇 |
1974年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
Anuj Shrestha Zeeshan Jawa Kathryn L. Koch Amy B. Rankin Qun Xiang Anand Padmanabhan Matthew S. Karafin Joshua J. Field 《Journal of clinical apheresis》2015,30(6):353-358
Red cell exchange (RCE) is a common procedure in adults with sickle cell disease (SCD). Implantable dual lumen Vortex (DLV) ports can be used for RCE in patients with poor peripheral venous access. We performed a retrospective cohort study of RCE procedures performed in adults with SCD. The main objective of the study was to compare the inlet speed, duration of procedures and rate of complications performed through DLV ports to those performed through temporary central venous and peripheral catheters. Twenty‐nine adults with SCD underwent a total of 318 RCE procedures. Twenty adults had DLV ports placed and 218 procedures were performed using DLV ports. Mean length of follow‐up after DLV port placement was 397 ± 263 days. Six DLV ports were removed due to infection and 1 for malfunction after a mean of 171 ± 120 days. Compared to temporary central venous and peripheral catheters, DLV port procedures had a greater rate of procedural complications, a longer duration, and a lower inlet speed (all P < 0.01). When accounting for the maximum allowable inlet speed to avoid citrate toxicity, 40% of DLV port procedures were greater than 10% below maximum speed, compared to 7 and 14% of procedures performed through temporary central venous and peripheral catheters (P < 0.0001). In conclusion, DLV ports can be used for RCE in adults with SCD, albeit with more procedural complications and longer duration. The smaller internal diameter and longer catheter of DLV ports compared to temporary central venous catheters likely accounts for the differences noted. J. Clin. Apheresis 30:353–358, 2015. © 2015 Wiley Periodicals, Inc. 相似文献
5.
6.
O’Beirne Sarah L. Chazen J. Levi Cornman-Homonoff Joshua Carey Bridget T. Gelbman Brian D. 《Lung》2019,197(6):727-733
Lung - Diaphragmatic paralysis (DP) is an important cause of dyspnea with many underlying etiologies; however, frequently no cause is identified despite extensive investigation. We hypothesized... 相似文献
7.
Joshua Manghelli Lisa Brown Hany B. Tadros Nabil A. Munfakh 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2015,42(5):491-494
The inflammatory response induced by cardiopulmonary bypass decreases vascular tone, which in turn can lead to vasoplegic syndrome. Indeed the hypotension consequent to on-pump cardiac surgery often necessitates vasopressor and intravenous fluid support. Methylene blue counteracts vasoplegic syndrome by inhibiting the formation of nitric oxide.We report the use of methylene blue in a 75-year-old man who developed vasoplegic syndrome after cardiac surgery. After the administration of methylene blue, his hypotension improved to the extent that he could be weaned from vasopressors. The use of methylene blue should be considered in patients who develop hypotension refractory to standard treatment after cardiac surgery. 相似文献
8.
Andriy
Derkach Steven C. Moore Simina M. Boca Joshua N. Sampson 《Statistics in medicine》2020,39(18):2423-2436
We consider the scenario where there is an exposure, multiple biologically defined sets of biomarkers, and an outcome. We propose a new two-step procedure that tests if any of the sets of biomarkers mediate the exposure/outcome relationship, while maintaining a prespecified familywise error rate. The first step of the proposed procedure is a screening step that removes all groups that are unlikely to be strongly associated with both the exposure and the outcome. The second step adapts recent advances in postselection inference to test if there are true mediators in each of the remaining candidate sets. We use simulation to show that this simple two-step procedure has higher statistical power to detect true mediating sets when compared with existing procedures. We then use our two-step procedure to identify a set of Lysine-related metabolites that potentially mediate the known relationship between increased body mass index and the increased risk of estrogen-receptor positive breast cancer in postmenopausal women. 相似文献
9.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
10.
C Edward Hoffler Kurt D Hankenson Joshua D Miller Sukhinderdeep K Bilkhu Steven A Goldstein 《Journal of orthopaedic research》2006,24(8):1687-1698
To understand in situ behavior of osteocytes, we characterized a model of osteocytes in their native bone matrix and demonstrated real-time biologic activity of osteocytes while bending the bone matrix. Using 43 male Sprague-Dawley rats, dumbbell-shaped explants were harvested from stainless steel femoral implants after 6-12 weeks and incubated in culture medium or fixed. Sixteen specimens were used to determine bone volume density (BV/TV), volumetric bone mineral density (BMD) and histology for different implantation periods. Osteocyte viability was evaluated by L-lactate dehydrogenase (LDH) activity in 12 cultured explants. Confocal microscopy was used to assess tracer diffusion in three explants and changes in osteocyte pH of a mechanically loaded explant. From 6 to 12 weeks, explant BV/TV and volumetric BMD trended up 92.5% and 101%, respectively. They were significantly and highly correlated. Tissues were uniformly intramembranous and all bone cell types were present. Explants maintained LDH activity through culture day 8. Diffusion at 200 microM was limited to 1,209 Da. Explants appeared capable of reproducing complex bone biology. This model may be useful in understanding osteocyte mechanotransduction in the context of a physiologically relevant bone matrix. 相似文献