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Concepción Núñez Diana Alecsandru Jezabel Varadé Isabel Polanco Carlos Maluenda Miguel Fernández-Arquero Emilio G de la Concha Elena Urcelay Alfonso Martínez 《BMC medical genetics》2006,7(1):32-5
Background
Celiac disease (CD) is a chronic disorder characterized by a pathological inflammatory response after exposure to gluten in genetically susceptible individuals. The HLA complex accounts for less than half of the genetic component of the disease, and additional genes must be implicated. Interleukin-10 (IL-10) is an important regulator of mucosal immunity, and several reports have described alterations of IL-10 levels in celiac patients. The IL-10 gene is located on chromosome 1, and its promoter carries several single nucleotide polymorphisms (SNPs) and microsatellites which have been associated to production levels. Our aim was to study the role of those polymorphisms in susceptibility to CD in our population. 相似文献3.
Sara Casado-Zapico Jezabel Rodriguez-Blanco Guillermo García-Santos Vanesa Martín Ana M. Sánchez-Sánchez Isaac Antolín Carmen Rodriguez 《Journal of pineal research》2010,48(1):72-80
Abstract: Ewing sarcoma, the second most frequent bone cancer type, affects mainly adolescents, who have a survival of 50% 5 yr after diagnosis. Current treatments include a combination of surgery, radiotherapy and chemotherapy, which present potential serious side effects. Melatonin, a natural molecule without relevant side effects, has been previously shown to induce cytotoxicity in SK-N-MC cells, a Ewing sarcoma cell line. Here, we found that there is a synergy in the antitumor effect when melatonin (50 μ m –1 m m ) is combined with vincristine at the concentration of 5–10 n m or with ifosfamide at the range of 100 μ m –1 m m . This synergism is due to the potentiation of cell death, particularly to the potentiation of apoptosis, i.e., mainly the extrinsic apoptotic pathway. There is a significant increase in the activation of caspase-3, -8, -9 and Bid when melatonin is combined with vincristine or ifosfamide compared to the individual treatments. Finally, there is also a potentiation of the early free radical production, likely dependent on the extrinsic apoptosis pathway activation, when the drugs are combined with melatonin. Other proteins which are related to this pathway including mitogen-activated protein kinase or protein kinase B/Akt are not involved in apoptosis induced by these agents separately or when combined. The results shown here together with the facts that: (i) no relevant side effects have been reported for melatonin and (ii) melatonin has a cytoprotective effect on noncancer cells, opens the door for a new approach in the treatment of the Ewing sarcoma family of tumors. 相似文献
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Angel Vila-Corcoles Olga Ochoa-Gondar Jorge A Guzmán Teresa Rodriguez-Blanco Elisabet Salsench Cruz M Fuentes EPIVAC Study Group 《BMC infectious diseases》2010,10(1):73
Background
The 23-valent polysaccharide pneumococcal vaccine (PPV) is currently recommended in elderly and high-risk adults. However, its efficacy in preventing pneumococcal infections remains controversial. This study assessed the clinical effectiveness of vaccination against invasive pneumococcal disease (IPD) among people over 60 years. 相似文献5.
Sánchez-Bueno F García Pérez R Torres Salmerón G Fernández-Carrión J Ramírez Romero P Parrilla Paricio P 《Cirugía espa?ola》2012,90(1):33-37
HELLP syndrome (HS) occurs in 0.5-0.9% of pregnant women. According to the Tennessee criteria, it is characterised by haemolytic anaemia, thrombopenia and multi-organ dysfunction. The purpose of this article is to present the cases of four pregnant women diagnosed with HS with severe liver involvement. PATIENTS AND METHOD: We present the cases of 4 pregnant women of 24, 27, 28 and 36 weeks gestation, respectively. Pregnancy was terminated by urgent Caesarean section in all 4 cases. The first case required a right hepatectomy, with a good post-operative outcome; the second patient developed fulminant liver failure, dying due to multi-organ failure while waiting for a liver transplant. The third patient progressed satisfactorily with conservative medical treatment. The fourth patient required two livers transplants, being discharged from hospital three months later. CONCLUSIONS: When faced with the clinical suspicion of a HS it is essential to rule out a liver haematoma, since the treatment of choice depends on its clinical-radiological severity. If there is a rupture of the haematoma, urgent surgery is essential and, in the case of severe liver failure, a liver transplant is indicated. 相似文献
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Miguel Mendoza-Puente Ángel Oliva-Pascual-Vaca Cleofás Rodriguez-Blanco Alberto Marcos Heredia-Rizo Daniel Torres-Lagares Francisco J. Ordoñez 《Archives of physical medicine and rehabilitation》2014
Objective
To evaluate differences in the incidence of headache, trigeminal nerve mechanosensitivity, and temporomandibular functionality in professional male boxers (exposed to repetitive craniofacial trauma) who were actively training and without severe previous injuries compared with handball players.Design
Case-control study.Setting
University-based physical therapy research clinic.Participants
Eighteen boxers (mean age, 23±4.61y) as the cases group, and 20 handball players as the comparison group (mean age, ±2y, and sex matched), were included. All participants (N=38) completed the assessment protocol.Interventions
Not applicable.Main Outcome Measures
Measurements were taken of the headache impact (Headache Impact Test-6) and the pressure pain threshold over the trigeminal nerve sensory branches, the masseter muscle, and the tibialis anterior muscle. The secondary outcome measure included the temporomandibular function (Helkimo Clinic Index).Results
The boxers showed slight mandibular function impairment, local muscular and neural sensitization, and a higher impact from headaches than did the handball players. The between-group comparison found significant differences in all outcome measures (P<.05), except in the tibialis anterior muscle pressure pain threshold on the dominant (P=.958) and the nondominant (P=.453) sides.Conclusions
Professional male boxers seem to suffer a greater headache impact and local sensitization of the craniomandibular region than do professional handball players. It cannot be determined whether these findings are short-lasting, as a result of the training activity, or long-lasting. 相似文献7.
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Raúl Medina Velázquez Laura Jiménez Díaz Jezabel Fernández Carrión Clara Rosas Bermúdez Montserrat Miralles Curto María Asunción Acosta Mérida Joaquín Marchena Gómez 《Cirugía espa?ola》2019,97(1):40-45
Introduction
The main step in curative treatment for breast cancer is surgery. Its use in an ambulatory setting can contribute towards more efficient healthcare, providing additional benefits for patients. In this study, we analyze the results obtained with this treatment method and identify factors related with conversion to hospitalization.Methods
Results were analyzed from the 206 surgeries performed for breast cancer in 2016, using three different methods: day surgery, overnight ambulatory (23 h) and conventional hospitalization. The ambulatory success and conversion rates were calculated for the global sample and stratified, distinguishing between conservative surgery, mastectomy and axillary surgery. A univariate analysis was performed to identify the factors involved in conversion.Results
For the global sample, the ambulatory surgery rate was 61.2%, 16.5% conversions and a success rate of 83.4%. For conservative surgery, ambulatory, success and conversion rates were 78.8%, 88.6 and 11.4%, respectively. For mastectomies, the ambulatory rate was 28.6%, with 62.9% success and 37.1% conversions. The 11 axillary surgeries were performed as day surgeries. Factors associated with conversion were mastectomy vs. vs. conservative surgery and the appearance of postoperative complications.Conclusions
Ambulatory surgery for the surgical treatment of breast cancer should be standard care. Optimized results require adequate patient selection and the performance of surgical technique that needs to be as careful and as conservative as possible. 相似文献9.
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María Jezabel Haye Salinas Soledad Retamozo Ana Cecilia Alvarez Hernán Maldonado Ficco Fernando Dal Pra Gustavo Citera Mariana Benegas Rafael Chaparro del Moral Oscar Rillo Anastasia Secco Lucila Marino Claverie Antonio Catalan Pellet Josefina Marcos Mercedes Argentina García Juan Carlos Marcos Ana Barbaglia Verónica Bellomio Alberto Berman Cristian Quiroz Enrique R Soriano Federico Ceccato Sergio Paira Doralia Vazquez Vicente Ricardo Juarez Edson Javier Velozo Gabriela Salvatierra Francisco Caeiro 《Rheumatology international》2015,35(5):855-859