全文获取类型
收费全文 | 2933篇 |
免费 | 249篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 85篇 |
妇产科学 | 26篇 |
基础医学 | 373篇 |
口腔科学 | 58篇 |
临床医学 | 294篇 |
内科学 | 748篇 |
皮肤病学 | 79篇 |
神经病学 | 274篇 |
特种医学 | 87篇 |
外科学 | 353篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 182篇 |
眼科学 | 101篇 |
药学 | 293篇 |
中国医学 | 2篇 |
肿瘤学 | 204篇 |
出版年
2023年 | 38篇 |
2022年 | 41篇 |
2021年 | 100篇 |
2020年 | 84篇 |
2019年 | 95篇 |
2018年 | 110篇 |
2017年 | 82篇 |
2016年 | 120篇 |
2015年 | 117篇 |
2014年 | 157篇 |
2013年 | 180篇 |
2012年 | 241篇 |
2011年 | 231篇 |
2010年 | 110篇 |
2009年 | 106篇 |
2008年 | 195篇 |
2007年 | 149篇 |
2006年 | 162篇 |
2005年 | 139篇 |
2004年 | 127篇 |
2003年 | 109篇 |
2002年 | 97篇 |
2001年 | 32篇 |
2000年 | 28篇 |
1999年 | 34篇 |
1998年 | 30篇 |
1997年 | 28篇 |
1996年 | 18篇 |
1995年 | 15篇 |
1994年 | 12篇 |
1993年 | 9篇 |
1992年 | 12篇 |
1991年 | 14篇 |
1990年 | 16篇 |
1989年 | 21篇 |
1988年 | 11篇 |
1987年 | 13篇 |
1986年 | 7篇 |
1985年 | 11篇 |
1984年 | 7篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 5篇 |
1979年 | 11篇 |
1978年 | 7篇 |
1977年 | 4篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1971年 | 4篇 |
排序方式: 共有3190条查询结果,搜索用时 31 毫秒
1.
Anders Elm Pedersen Esben Gjerløff Wedebye Schmidt Jesper Freddie Sørensen Carsten Faber Boye Schnack Nielsen Kim Holmstrøm Silje Haukali Omland Peter Tougaard Søren Skov Bo Bang 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(7):547-555
TL1A is a TNF‐like cytokine which has been shown to co‐stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐TNF‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL1A as a biomarker. 相似文献
2.
3.
4.
Jesper Carl Thomas Bro Christensen Hans von der Maase 《Acta oncologica (Stockholm, Sweden)》1992,31(7):749-753
This study presents an analysis on longitudinal tumour marker series in twenty-two patients with non-seminomatous germ cell cancers treated with cisplatinum (DDP) based combination chemotherapy. Series of alphafoetoprotein (AFP), human chorionic gonadotropin (HCG) and lactate dehydrogenase (LDH) were analyzed applying a dynamic mathematical marker model. The model analysis provided quantitated values for growth rate and treatment response in the marker producing cells. The analysis showed that LDH had to be above 2 000 U/l to be a trustworthy tumour marker. HCG producing cells tended to grow faster than AFP producing cells, and were 3-5-fold more sensitive to the chemotherapy given than AFP producing cells. Treatment response versus DDP dose appeared to be bi-phasic, but with no significant change in treatment efficiency within the given range of DDP doses. 相似文献
5.
C Pedersen C M Nielsen B F Vestergaard J Gerstoft K Krogsgaard J O Nielsen 《British medical journal》1987,295(6598):567-569
A total of 276 sequential serum samples from 34 men with antibodies to the human immunodeficiency virus (HIV) followed up for two to seven years were analysed for HIV antigen and antibodies to the viral core and envelope proteins. Results were correlated with clinical outcome and CD4 T lymphocyte count. Both antigenaemia and the disappearance of antibodies to the core protein were associated with development of the acquired immune deficiency syndrome (AIDS) or AIDS related complex and depletion of CD4 cells. Thus AIDS or AIDS related complex developed in eight out of 16 patients with antigenaemia compared with one out of 18 patients without antigenaemia. Low counts of CD4 cells (less than 0.5 X 10(9)/l) were found in 14 of the 16 patients with antigenaemia and five of the 18 without antigenaemia. Nine patients seroconverted to HIV during the study; two of these developed antigenaemia 14 and 16 months after the estimated time of seroconversion. These results show that the late stages of HIV infection are characterised by increased production of antigen and a decrease in antibodies directed against the core protein. Antigenaemia indicates a poor prognosis; and as the antigen test is simple to do and interpret, it may therefore be useful for selecting patients for antiviral treatment. 相似文献
6.
C Nielsen P C G?tzsche C M Nielsen J Gerstoft B F Vestergaard 《Antiviral research》1992,18(3-4):303-316
An assay based on production of HIV antigen in cultures of CD4+ lymphocytes infected 'in vitro' with cell-free virus was established. Using this assay it was possible to isolate, propagate and reliably determine the zidovudine susceptibility of HIV isolates from all patients despite differences in cellular tropism and syncytium inducing capacity. Using this assay, differences in zidovudine susceptibility of 52 serial isolates obtained from 16 patients before and after initiation of therapy were examined. HIV with a 10- to 100-fold reduced susceptibility to zidovudine were isolated from 13 patients as early as 4 months after initiation of therapy. Number of months of zidovudine treatment was strongly associated with development of viral resistance, and high CD4 cell counts tended to be associated with lower rates of development of resistance. That patients can harbor mixtures of virus strains with different susceptibility to zidovudine was confirmed by the differences in susceptibility between isolates obtained simultaneously from CD4+ lymphocyte and plasma, and by the differences in susceptibility between virus strains isolated from clones of CD4+ lymphocytes. 相似文献
7.
8.
L B Jensen P Vestergaard A P Hermann J Gram P Eiken B Abrahamsen C Brot N Kolthoff O H S?rensen H Beck-Nielsen S Pors Nielsen P Charles L Mosekilde 《Journal of bone and mineral research》2003,18(2):333-342
The aim of this study was to study the influence of hormone replacement therapy (HRT) on weight changes, body composition, and bone mass in early postmenopausal women in a partly randomized comprehensive cohort study design. A total of 2016 women ages 45-58 years from 3 months to 2 years past last menstrual bleeding were included. One thousand were randomly assigned to HRT or no HRT in an open trial, whereas the others were allocated according to their preferences. All were followed for 5 years for body weight, bone mass, and body composition measurements. Body weight increased less over the 5 years in women randomized to HRT (1.94 +/- 4.86 kg) than in women randomized to no HRT (2.57 +/- 4.63, p = 0.046). A similar pattern was seen in the group receiving HRT or not by their own choice. The smaller weight gain in women on HRT was almost entirely caused by a lesser gain in fat. The main determinant of the weight gain was a decline in physical fitness. Women opting for HRT had a significantly lower body weight at inclusion than the other participants, but the results in the self-selected part of the study followed the pattern found in the randomized part. The change in fat mass was the strongest predictor of bone changes in untreated women, whereas the change in lean body mass was the strongest predictor when HRT was given. Body weight increases after the menopause. The gain in weight is related to a decrease in working capacity. HRT is associated with a smaller increase in fat mass after menopause. Fat gain protects against bone loss in untreated women but not in HRT-treated women. The data suggest that women's attitudes to HRT are more positive if they have low body weight, but there is no evidence that the conclusions in this study are skewed by selection bias. 相似文献
9.
10.