State of the endocrine and cardiovascular systems in patients with somatotropin-producing hypophyseal adenoma]

Altogether 16 persons with STH-producing hypophyseal adenoma were investigated by tacho-oscillography, total rheography, blood taken from the ulnar vein, a radioimmunoassay to determine the levels of STH, ACTH, cortisol, deoxycorticosterone, aldosterone, T3, T4, vasopressin, prostaglandin E2, 6-keto-prostaglandin F1 alpha, and plasma renin activity. Acromegalic patients demonstrated an elevated level of STH, and prostaglandin E2 secretion was inhibited. Two groups of patients were singled out according to the hemodynamic state: the 1st group was characterized by a hyperkinetic type of circulation and normotension of borderline hypertension; the 2nd group was characterized by hypokinetic circulation, increased vascular resistance, labile or stable arterial hypertension. The interrelationship of hemodynamic and hormonal indices was unnoticed. It has been assumed that of pathogenetic importance in the development of arterial hypertension is depletion of E2 production, and at early stages--body liquid retention resulting from hypersomatotropinemia.     

Changes in the indices of the coronary amd myocardial reserves in myocardial infarct patients during rehabilitation]

The article analyses the results of the complex examination of 52 patients with large-focal and through-and-through myocardial infarction using veloergometry, echocardiography, tetrapolar rheography, diurnal ECG monitoring at cardioanalyzer. It was found out that veloergometry was more preferable in the late hospital period. Echocardiography was more preferable in the sanitary-polyclinic period for the young and middle-aged patients with through-and-through myocardial infarction, and at the late hospital period for elderly patients with large-focal and through-and-through myocardial infarction. In both periods described above echocardiography was effective in young and middle-aged patients with large-focal myocardial infarction. As for the volume of information obtained with the help of tetrapolar rheography and diurnal ECG monitoring it was equal in both periods.     

Effect of a single dose of parlodel on the secretion of various hormones in Itsenko-Cushing disease

The results of investigation of the secretion of hypophyseal, adrenal and renal hormones resulting from parlodel administration in 44 patients with Itsenko-Cushing disease were discussed. Concentrations of corticotropin (ACTH), prolactin, somatotropin (STH), thyrotropin (TSH), cortisol, aldosterone, adrenalin, noradrenaline, dopamine and blood renin activity were determined by radioimmunoassays and radioenzymatic methods on an empty stomach and 30, 60 min., 2, 4 and 24 h after parlodel administration (2.5 mg) per os. Parlodel administration in Itsenko-Cushing disease was shown to cause a decrease in the secretion of hypophyseal hormones (ACTH, prolactin and STH). The level of cortisol raised before the start of the investigation was gradually decreased after the drug administration and reached its minimum in 2-4 h. Correlation of the basal level of aldosterone and blood renin activity, and a response of the renin-angiotensin-aldosterone system to parlodel administration was revealed. Changes in the secretion of catecholamines were of diverse nature: a decrease in the blood concentration of noradrenaline in the absence of adrenalin and dopamine shifts.     

Clinico-immunological characteristics of acute pneumonia in young patients

Altogether 103 patients with acute pneumonia and 50 healthy controls were examined. A wide range of clinical and immunological methods was applied. The data obtained were processed using statistical multivariate analyses. Differences of a clinical picture and the immune status were shown in primary patients and in patients with repeated pneumonia. An attempt was made to explain the pathogenesis of repeated pneumonia. The use of immunomodulating agents for therapy and prevention of acute pneumonia was substantiated.