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Hori Hiroki Ohta Asuka Matsui Honami Yano Kanako Morita-Tominaka Miyuki Linn Zayar Masumoto Daisuke Okumura Yosuke Okamura Satoshi Kurihara Kosuke Hayakawa Akira Rikiishi Takeshi Kobayashi Kyoko 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(1):245-252
International Journal of Clinical Oncology - The practice of cancer diagnosis disclosure to children has been changed with the times. The regulations of clinical trials in the 2000s might change... 相似文献
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Despite considerable efforts to improve early detection, and advances in chemotherapy, metastasis remains a major challenge in the clinical management of ovarian cancer. Studies of new murine models are providing novel insights into the pathophysiology of ovarian cancer, but these models are not readily amenable to genetic screens. Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets. 相似文献
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Fukase S Kazama JJ Mori H Iguchi S Takeda T Ueno M Nishi S Narita I Gejyo F 《Clinical and experimental nephrology》2006,10(1):33-39
Background Electron-dense deposits are often found around glomerular capillary lumens in patients with glomerulonephritis, forming a
portion of the blood-urine barrier (BUB).
Methods Four hundred and four patients with primary glomerular diseases or donors for living-related kidney transplantation who underwent
both percutaneous renal biopsy and renal clearance tests were included in the study. Sodium thiosulfate and paraamino hippurate
double-clearance studies were performed with catheterized urinary collection. The filtration fraction (FF) was determined
as follows: FF = sodium thiosulfate clearance/paraamino hippurate clearance (Cpah). Histomorphometric analyses were performed in 53 patients with overt para-capillary electron-dense deposits (PCEDD) by electron
microscopic observations.
Results Patients with membranous nephropathy and membranoproliferative glomerulonephritis showed significantly lower levels of FF
than the donors for living-rebated kidney transplantation (normal controls). FF levels were significantly lower in patients
with PCEDD than in those without (P < 0.001), while the levels of mean blood pressure and Cpah were comparable in the two groups. The PCEDD/BUB ratio demonstrated a significant negative correlation with FF (P < 0.0001; r2 = 0.331). Patients with a ratio of 0.5 or more showed significantly lower FF levels than those with a ratio of 0.25 or less.
Conclusions PCEDD significantly affected FF levels in patients with primary glomerular diseases. FF may not be an accurate indicator of
intraglomerular blood pressure in patients with overt PCEDD. 相似文献
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Tetsuji Onoue Honami Sato Tomoki Nakamura Takaaki Noguchi Yoshihiro Hidaka Naoki Shirai Mitsuru Ebihara Takahito Osawa Yuichi Hatsukawa Yosuke Toh Mitsuo Koizumi Hideo Harada Michael J. Orchard Munetomo Nedachi 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(47):19134-19139
The 34-million-year (My) interval of the Late Triassic is marked by the formation of several large impact structures on Earth. Late Triassic impact events have been considered a factor in biotic extinction events in the Late Triassic (e.g., end-Triassic extinction event), but this scenario remains controversial because of a lack of stratigraphic records of ejecta deposits. Here, we report evidence for an impact event (platinum group elements anomaly with nickel-rich magnetite and microspherules) from the middle Norian (Upper Triassic) deep-sea sediment in Japan. This includes anomalously high abundances of iridium, up to 41.5 parts per billion (ppb), in the ejecta deposit, which suggests that the iridium-enriched ejecta layers of the Late Triassic may be found on a global scale. The ejecta deposit is constrained by microfossils that suggest correlation with the 215.5-Mya, 100-km-wide Manicouagan impact crater in Canada. Our analysis of radiolarians shows no evidence of a mass extinction event across the impact event horizon, and no contemporaneous faunal turnover is seen in other marine planktons. However, such an event has been reported among marine faunas and terrestrial tetrapods and floras in North America. We, therefore, suggest that the Manicouagan impact triggered the extinction of terrestrial and marine organisms near the impact site but not within the pelagic marine realm. 相似文献
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Aberrant expression of homeobox gene HOXA7 is
associated with müllerian-like differentiation of epithelial
ovarian tumors and the generation of a specific autologous
antibody response
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Honami Naora Fredrick J. Montz Chee-Yin Chai Richard B. S. Roden 《Proceedings of the National Academy of Sciences of the United States of America》2001,98(26):15209-15214
Autologous serum antibodies to molecules that are aberrantly expressed in tumors represent potential biomarkers for early diagnosis of cancer. In this study, we identified the homeobox gene HOXA7 as encoding an antigen in epithelial tumors of the ovary. These tumors are thought to arise from the simple epithelium lining the ovarian surface, but they often resemble the specialized epithelia derived from the müllerian ducts. Expression of HOXA7 was detected in ovarian tumors exhibiting müllerian-like features and correlated with the generation of anti-HOXA7 antibodies by patients. In contrast, it was observed that healthy women lack anti-HOXA7 antibodies (P < 0.0001) and that HOXA7 expression is absent from normal ovarian surface epithelium. Interestingly, HOXA7 expression was detected in the müllerian-like epithelium lining inclusion cysts in normal ovaries and in the müllerian duct-derived epithelium of normal fallopian tubes. Furthermore, ectopic expression of HOXA7 enhanced the epithelial phenotype of immortalized ovarian surface epithelial cells, as indicated by the appearance of cobblestone morphology, induction of E-cadherin expression, and down-regulation of vimentin. These findings associate aberrant HOXA7 expression with the müllerian-like differentiation of epithelial ovarian tumors and suggest diagnostic utility of serum antibodies to HOXA7. 相似文献
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Yoshida I Ando K Ando Y Ookawara S Suzuki M Furuya H Iimura O Takada D Kajiya M Komada T Mori H Tabei K;BVM Study Group 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2010,14(6):560-565