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排序方式: 共有260条查询结果,搜索用时 406 毫秒
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Birgitte Lidegaard Frederiksen Merete Osler Henrik Harling Steen Ladelund Torben Jørgensen 《Social science & medicine (1982)》2009
This paper investigates the association between individually measured socioeconomic status (SES) and all-cause survival in colorectal cancer patients, and explores whether factors related to the patient, the disease, or the surgical treatment mediate the observed social gradient. 相似文献
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MIA SON JEONG‐OK KONG SANG‐BAEK KOH JAEYOUNG KIM MIKKO HÄRMÄ 《Journal of sleep research》2008,17(4):385-394
We investigated the effects of 12‐hour shift work for five to seven consecutive days and overtime on the prevalence of severe sleepiness in the automobile industry in Korea. [Correction added after online publication 28 Nov: Opening sentence of the summary has been rephrased for better clarity.] A total of 288 randomly selected male workers from two automobile factories were selected and investigated using questionnaires and sleep‐wake diaries in South Korea. The prevalence of severe sleepiness at work [i.e. Karolinska Sleepiness Scale (KSS) score of 7 or higher] was modeled using marginal logistic regression and included theoretical risk factors related to working hours and potential confounding factors related to socio‐economic status, work demands, and health behaviors. Factors related to working hours increased the risk for severe sleepiness at the end of the shift in the following order: the night shift [odds ratio (OR): 4.7; 95% confidence interval (CI): 3.6–6.0)], daily overtime (OR: 2.2; 95% CI: 1.7–2.9), weekly overtime (OR: 1.6; 95% CI: 1.0–2.6), and night overtime (OR: 1.6; 95% CI: 0.8–3.0). Long working hours and shift work had a significant interactive effect for severe sleepiness at work. Night shift workers who worked for 12 h or more a day were exposed to a risk of severe sleepiness that was 7.5 times greater than day shift workers who worked less than 11 h. Night shifts and long working hours were the main risk factors for severe sleepiness among automobile factory workers in Korea. Night shifts and long working hours have a high degree of interactive effects resulting in severe sleepiness at work, which highlight the need for immediate measures to address these characteristics among South Korean labor force patterns. 相似文献
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Damario MA; Barmat L; Liu HC; Davis OK; Rosenwaks Z 《Human reproduction (Oxford, England)》1997,12(11):2359-2365
Certain patients have a tendency for high response to gonadotrophin therapy
which is often not ameliorated with prior gonadotrophin- releasing hormone
agonist (GnRHa) suppression. As a result, these patients are frequently
cancelled and often experience ovarian hyperstimulation syndrome (OHSS)
episodes during in-vitro fertilization (IVF)-embryo transfer cycles.
Patients with polycystic ovarian syndrome (PCOS) have been noted to be
particularly sensitive to exogenous gonadotrophin therapy. We have
developed a protocol which is effective in improving IVF outcome in high
responder patients, including those with PCOS. Oral contraceptive pills
(OCP) are taken for 25 days followed by s.c. leuprolide acetate, 1 mg/day,
which is overlapped with the final 5 days of oral contraceptive
administration. Low-dose gonadotrophin stimulation is then initiated on the
third day of withdrawal bleeding in the form of either human menopausal
gonadotrophins or purified urinary follicle-stimulating hormone at a dosage
of 150 IU/day. Over a 5 year period, we reviewed our experience utilizing
this dual method of suppression in 99 cycles obtained in 73 high responder
patients. There were only 13 cancellations prior to embryo transfer
(13.1%). The clinical and ongoing pregnancy rates per initiated cycle were
46.5 and 40.4% respectively. Only eight patients experienced mild-moderate
OHSS following treatment. For those patients who had undergone previous
IVF-embryo transfer cycles at our centre, significant improvements were
noted in oocyte fertilization rates, embryo implantation rates and
clinical/ongoing pregnancy rates with this protocol. Hormonal analyses
revealed that the chief mechanism may be through an improved luteinizing
hormone/follicle-stimulating hormone ratio following dual suppression. An
additional feature of this dual method of suppression is significantly
lower serum androgen concentrations, particularly dehydroepiandrosterone
sulphate.
相似文献
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A school-based study was implemented to assess the family history of coronary heart disease (CHD) and hyperlipidemia (HL) in relation to serum lipoprotein and apolipoprotein levels. One hundred and twenty-five elementary school students (aged9–10 years) and 297 junior high school students (aged12–13 years) participated. Family history was evaluated by the following scoring method: positive family history in a parent. 2 points: in a grandparent. 1 point: and onset of CHD before age 60, 1 additional point. Family history of HL was positive in 8.2% of elementary school students, and 4.2% in junior high school students. Family history of CHD was positive in 11.5% of elementary students, and 11.0% in junior students. Family history score (FHS) for HL was related to serum total cholesterol (TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol, apolipoprotein A-T, apolipoprotein B (apoB) and lipoprotein (a) in elementary students, and to TC, LDLC, triglyceride and apoB in junior students. There was no relationship between FHS for CHD and serum lipoprotein or apolipoprotein levels in any student. The children with a positive FH of HL already demonstrated an atherogenic lipid profile while those with FH of CHD did not. which was probably because lipid profiles in children are more genetically mediated by a FH of HL than of CHD. 相似文献
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S Harling I Hansen‐Pupp A Baigi E Pesonen 《Acta paediatrica (Oslo, Norway : 1992)》2011,100(2):231-235
Aim: To evaluate the efficacy of various echocardiographic markers in predicting a patent ductus arteriosus (PDA) in need of treatment. Methods: Forty‐five preterm infants with a mean (SD) gestational age of 27.7 (1.9) weeks underwent echocardiography at a postnatal age of 24 ± 6 and 72 ± 6 h. Four echocardiographic markers were studied: ductus diameter, ductal flow Doppler curves, the left atrial to aortic root (LA/Ao) ratio and Doppler pixels representing ductal shunting. Results: Twenty‐eight infants had a PDA with a detectable left‐to‐right shunt. Of these, 12 (43%) were treated for a shunt through the PDA. Ductal diameter was the most accurate echocardiographic marker when it came to predicting a significant shunt, with a sensitivity of 89%, a specificity of 70%, a positive likelihood ratio of 2.97 and a negative likelihood ratio of 0.16 at the age of 72 h. The efficacy of the method at 72 h of age was 84%. The corresponding efficacy of the pulsatile Doppler curve was 72%, percentage of green colour pixels 63% and the LA/Ao ratio 53%. Conclusion: Ductus diameter appears to be the most important variable in determining the need for therapeutic intervention for PDA in preterm infants. 相似文献