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Wei Wang Wei-Dong Jia Ge-Liang Xu Zhi-Hua Wang Jian-Sheng Li Jin-Liang Ma Yong-Sheng Ge Sheng-Xue Xie Ji-Hai Yu 《Digestive diseases and sciences》2009,54(10):2128-2136
Rapamycin (RAPA) inhibits tumor growth and angiogenesis in hepatocellular carcinoma (HCC). The molecular mechanism underlying
the antitumoral effects of RAPA remains unclear. Here we established a chemical-induced rat HCC model to investigate the signaling
pathways mediating RAPA’s antitumor activity. We found that RAPA exposure significantly diminished tumor growth, angiogenesis,
and metastasis of HCC. Meanwhile, the antitumor drug dramatically decreased expression of HIF-1alpha and VEGF, either at mRNA
or protein levels. Moreover, the low-dose of RAPA (1.5 mg/kg/day) was effective enough to markedly inhibit tumor progression
of HCC. The preliminary results suggested that the antitumoral effects of RAPA might be at least partially mediated through
downregulation of HIF-1alpha and VEGF, and low-dose RAPA-based regimens exhibited a promising future in treatment of HCC. 相似文献
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肝癌手术的非接触分离技术研究进展 总被引:1,自引:0,他引:1
许戈良 《世界华人消化杂志》2010,18(5)
为了避免手术时肿瘤细胞的播散,在切除肿瘤部分前先将肿瘤区域的淋巴、血管结扎、离断,这种技术称之为"非接触分离技术".对于肝癌的手术,传统的方法是在离断肝实质之前,充分游离预切除的肝叶,并旋转肝脏托至切口的前面,以便在肝外对肝静脉和第三肝门进行控制.这种手术可能会导致肝脏的缺血再灌注损伤,诱导休眠期肿瘤细胞释放前血管生成刺激因子促进VEGF水平的上升,加快其微小灶转移的进展,而肝脏手术旋转过程中对肿瘤的挤压可能会加重肿瘤细胞随血循环播散或在肝内门静脉系统播散的机率.肝癌手术的非接触分离技术是一项减少肝脏损害,防止术中转移和术后复发,值得深入探讨的新策略. 相似文献
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1991年4月至1995年8月18例下腔静脉阻塞所致布-加综合征患者接受了单球囊扩张治疗,其中膜型10例,段型8例,除1例段型穿刺激破膜失败外,余17例均成功地扩张致10-20mm,gufq15.2mm,阻塞下方下腔静脉压力从平均2.8kPa下降至1.4kPa,随访1-54月,除2例段型术后出现再狭窄外,余15例均下腔静脉通畅,症状缓解。上下腔同时插管造影,阻塞段部位、长度显示清楚,同时上方之导管 相似文献
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