全文获取类型
收费全文 | 29395篇 |
免费 | 1632篇 |
国内免费 | 264篇 |
专业分类
耳鼻咽喉 | 250篇 |
儿科学 | 571篇 |
妇产科学 | 607篇 |
基础医学 | 2959篇 |
口腔科学 | 707篇 |
临床医学 | 2080篇 |
内科学 | 8311篇 |
皮肤病学 | 374篇 |
神经病学 | 2529篇 |
特种医学 | 1106篇 |
外科学 | 5424篇 |
综合类 | 60篇 |
一般理论 | 7篇 |
预防医学 | 1172篇 |
眼科学 | 536篇 |
药学 | 1902篇 |
中国医学 | 61篇 |
肿瘤学 | 2635篇 |
出版年
2024年 | 31篇 |
2023年 | 295篇 |
2022年 | 616篇 |
2021年 | 1054篇 |
2020年 | 597篇 |
2019年 | 859篇 |
2018年 | 1031篇 |
2017年 | 745篇 |
2016年 | 922篇 |
2015年 | 913篇 |
2014年 | 1252篇 |
2013年 | 1537篇 |
2012年 | 2330篇 |
2011年 | 2233篇 |
2010年 | 1283篇 |
2009年 | 1229篇 |
2008年 | 1927篇 |
2007年 | 1869篇 |
2006年 | 1750篇 |
2005年 | 1739篇 |
2004年 | 1645篇 |
2003年 | 1403篇 |
2002年 | 1274篇 |
2001年 | 173篇 |
2000年 | 173篇 |
1999年 | 208篇 |
1998年 | 227篇 |
1997年 | 183篇 |
1996年 | 172篇 |
1995年 | 163篇 |
1994年 | 139篇 |
1993年 | 129篇 |
1992年 | 125篇 |
1991年 | 97篇 |
1990年 | 107篇 |
1989年 | 99篇 |
1988年 | 86篇 |
1987年 | 60篇 |
1986年 | 69篇 |
1985年 | 52篇 |
1984年 | 44篇 |
1983年 | 52篇 |
1982年 | 55篇 |
1981年 | 37篇 |
1980年 | 34篇 |
1979年 | 31篇 |
1978年 | 22篇 |
1977年 | 17篇 |
1976年 | 20篇 |
1974年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Exhaled nitric oxide in children with allergic rhinitis: A potential biomarker of asthma development 下载免费PDF全文
2.
3.
4.
F. Murina R. Felice S. Di Francesco L. Nelvastellio I. Cetin 《Gynecological endocrinology》2020,36(5):431-435
AbstractThis study is a single-center, retrospective analysis of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60?mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene?+?laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene?+?laser group compared with the laser treatment group (?87% vs???34%, respectively), and the vestibular health score started declining faster in the ospemifene?+?laser group. Although, additional research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clinical effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause. 相似文献
5.
Bruno Ferrari Antonio Pezzuto Lorenzo Barusi Francesco Coppola 《Gynecological endocrinology》2006,22(6):289-296
The aim of the present study was to investigate the effect of gonadotropin-releasing hormone (GnRH) antagonists (GnRH-ant) on follicular fluid (FF) insulin-like growth factor-I (IGF-I) and FF vascular endothelial growth factor (VEGF) levels. Sixty women undergoing assisted reproduction were randomized and assigned to two different GnRH analog regimens: GnRH agonist (GnRH-a) and GnRH-ant. FF VEGF and FF IGF-I concentrations were significantly increased in the patients treated with GnRH-ant (p < 0.001). In the same patients we observed a statistically significant reduction in serum luteinizing hormone (LH) and estradiol (E2) levels (p < 0.001 and p < 0.05, respectively), FF E2 and FF androstenedione levels (p < 0.05 and p < 0.001, respectively), as well as a reduction in the number of pregnancies although this was not statistically significant. In the GnRH-ant group, FF VEGF levels were positively correlated with FF IGF-I levels, and both were negatively correlated with serum LH levels. The increase in FF IGF-I and FF VEGF levels in women treated with GnRH-ant could be explained by a deleterious follicular environment in response to profound suppression of LH and E2 levels. 相似文献
6.
Conference Reports: This section contains reports on topical conferences. Reports are usually written at the request of the editorial office, but unsolicited contributions are also welcome. Suggestions should be sent to the editorial office of the Macromolecular journals, preferably by E‐mail to macromol@wiley‐vch.de. 相似文献
7.
8.
Nicola Martinelli Domenico Girelli Paolo Ferraresi Oliviero Olivieri Barbara Lunghi Franco Manzato Roberto Corrocher Francesco Bernardi 《Blood coagulation & fibrinolysis》2007,18(2):125-129
A common factor V gene haplotype, the FVR2 haplotype (FVHR2), has been associated with a reduced cofactor activity in activated protein C-mediated activated factor VIII inactivation. Our aim was to investigate the role of FVHR2 as a possible determinant of factor VIII levels in a population study. A total of 516 individuals (401 men, 115 women; mean age 58.4 +/- 10.8 years) were enrolled within the frame of a regional cardiovascular survey, characterized for factor VIII coagulant activity (FVIII:c) and factor V coagulant activity (FV:c) levels, and genotyped for factor V polymorphisms. In men without signs of overt inflammation, FVHR2 carriers had higher levels of FVIII:c than noncarriers (154 IU/dl, 95% confidence interval = 143-166 versus 142 IU/dl, 95% confidence interval = 138-147; P = 0.045) and were more represented in individuals with high (> or = 150 IU/dl) FVIII:c levels (21.2 versus 10.8%; odds ratio = 2.27, 95% confidence interval = 1.17-4.39 after adjustment for age, blood group and high-sensitivity C-reactive protein levels). In conclusion, this clinical report suggests the common FVHR2 as a possible independent determinant of FVIII:c levels. The report concomitantly addresses the relationship between factor V and factor VIII levels and supports the hypothesis of a mild prothrombotic role of FVHR2 by means of increased factor VIII levels. 相似文献
9.
10.
Monica Conciatori Christopher J Stodgell Susan L Hyman Melanie O'Bara Roberto Militerni Carmela Bravaccio Simona Trillo Francesco Montecchi Cindy Schneider Raun Melmed Maurizio Elia Lori Crawford Sarah J Spence Lucianna Muscarella Vito Guarnieri Leonardo D'Agruma Alessandro Quattrone Leopoldo Zelante Daniel Rabinowitz Tiziana Pascucci Stefano Puglisi-Allegra Karl-Ludvig Reichelt Patricia M Rodier Antonio M Persico 《Neuropsychopharmacology》2004,55(4):413-419
BACKGROUND: The HOXA1 gene plays a major role in brainstem and cranial morphogenesis. The G allele of the HOXA1 A218G polymorphism has been previously found associated with autism. METHODS: We performed case-control and family-based association analyses, contrasting 127 autistic patients with 174 ethnically matched controls, and assessing for allelic transmission disequilibrium in 189 complete trios. RESULTS: A, and not G, alleles were associated with autism using both case-control (chi(2) = 8.96 and 5.71, 1 df, p <.005 and <.025 for genotypes and alleles, respectively), and family-based (transmission/disequilibrium test chi(2) = 8.80, 1 df, p <.005) association analyses. The head circumference of 31 patients carrying one or two copies of the G allele displayed significantly larger median values (95.0th vs. 82.5th percentile, p <.05) and dramatically reduced interindividual variability (p <.0001), compared with 166 patients carrying the A/A genotype. CONCLUSIONS: The HOXA1 A218G polymorphism explains approximately 5% of the variance in the head circumference of autistic patients and represents to our knowledge the first known gene variant providing sizable contributions to cranial morphology. The disease specificity of this finding is currently being investigated. Nonreplications in genetic linkage/association studies could partly stem from the dyshomogeneous distribution of an endophenotype morphologically defined by cranial circumference. 相似文献