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C. Buffaz C. Scholtes A.-G. Dron P. Chevallier-Queyron J. Ritter P. André C. Ramière 《European journal of clinical microbiology & infectious diseases》2014,33(6):1037-1043
Purpose
In developed countries, hepatitis E virus (HEV) is considered an emerging pathogen, but prevalence seems highly variable according to previous European studies. As HEV can lead to chronic infections in immunosuppressed patients, it is thus essential to evaluate the prevalence and incidence of this infection.Methods
We determined retrospectively, in a cohort of 206 pediatric and adult liver transplant recipients from the Rhône-Alpes region in France, pre-transplant anti-HEV-IgG prevalence and incidence of HEV infections during post-transplant follow-up (HEV IgG and IgM ± HEV-RNA).Results
Transplantations were carried out between 2005 and 2012 and mean post-transplant follow-up was 32.8 months. Global pre-transplant prevalence of anti-HEV IgG was 29 %, increasing regularly with age from 7 % for children under 15 to 49 % for patients older than 60. From the 142 seronegative patients before transplant, 11 seroconversions (7.7 %) were observed during follow-up (incidence of 2.83 cases per 100 person-years). HEV RNA—tested at transaminases peak or randomly—was detected in only one case of seroconversion. For at least 2 HEV-seropositive patients, who had negative RNAemia before transplantation, viral RNA was detected chronically during follow-up, suggesting reinfection with HEV.Conclusion
Acute infections were largely more frequent than chronic infections and were asymptomatic or misdiagnosed, suggesting that liver transplant patients may not be particularly prone to developing severe HEV hepatitis. In addition, the presence of IgG anti-HEV may not protect against re-infection. Serological testing, therefore, appears to be of limited interest for the diagnosis of HEV infections in liver transplant recipients. 相似文献3.
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Punam Gauchan Tsugunobu Andoh Atsushi Kato Atsushi Sasaki Yasushi Kuraishi 《Journal of pharmacological sciences》2009,109(3):469-472
This study examined in mice whether limaprost, a prostaglandin E1 analog, would relieve allodynia induced by chemotherapeutic agents. Single intraperitoneal injections of paclitaxel, oxaliplatin, and vincristine sulfate induced and gradually increased mechanical allodynia. Repeated administration of limaprost alfadex inhibited the late, but not early, phase of mechanical allodynia induced by paclitaxel and oxaliplatin, but not vincristine. Paclitaxel and oxaliplatin, but not vincristine, gradually decreased peripheral blood flow, which was prevented by limaprost. These results suggest that limaprost is effective against mechanical allodynia induced by paclitaxel and oxaliplatin, which may be due to inhibition of the decrease in peripheral blood flow. 相似文献
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P. Dron M.P. Lafourcade F. Leprince C. Nonotte-Varly X. Van Der Brempt L. Banoun I. Sullerot C. This-Vaissette L. Parisot D.A. Moneret-Vautrin 《Revue Fran?aise d'Allergologie et d'Immunologie Clinique》2007
Piercing and tattooing are the most commonly encountered body modifications. Besides risks of infection and scarring, allergic reactions can also occur. The present multicentric study was the first carried out to evaluate the frequency of allergy consultation for such problems. Of the 138 allergists who responded to two questionnaires, 7.9% had observed allergies to piercing and 18.9% had identified an allergy to long-term henna tattoos. Contact eczema, rhinitis and urticaria were associated with an allergy to nickel. Contact eczema, generalized eczema, pruritis and edema caused by tattoos had been observed. Sensitivity to paraphenyline diamine (PPD) was established in 20/28 cases. After reviewing the literature, we emphasize the risk of serious allergy to PPD, of the need for long term surveillance because of the risk of cutaneous lymphocytoma, and of the difficulty of treating certain cases, all of which require close follow-up. 相似文献
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D. O'Sullivan P. Tosi Francine Creusot B. M. Cooke Thi-Hai Phan M. Dron Thierry Langin 《Current genetics》1998,33(4):291-298
The genome structure of Colletotrichum lindemuthianum in a set of diverse isolates was investigated using a combination of physical and molecular approaches. Flow cytometric measurement
of genome size revealed significant variation between strains, with the smallest genome representing 59% of the largest. Southern-blot
profiles of a cloned fungal telomere revealed a total chromosome number varying from 9 to 12. Chromosome separations using
pulsed-field gel electrophoresis (PFGE) showed that these chromosomes belong to two distinct size classes: a variable number
of small (< 2.5 Mb) polymorphic chromosomes and a set of unresolved chromosomes larger than 7 Mb. Two dispersed repeat elements
were shown to cluster on distinct polymorphic minichromosomes. Single-copy flanking sequences from these repeat-containing
clones specifically marked distinct small chromosomes. These markers were absent in some strains, indicating that part of
the observed variability in genome organization may be explained by the presence or absence, in a given strain, of dispensable
genomic regions and/or chromosomes.
Received: 2 September / 8 December 1997 相似文献
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Lan Anh T. Tran Lay Myint Yoshida Toyoko Nakagomi Punita Gauchan Koya Ariyoshi Dang Duc Anh Osamu Nakagomi Vu Dinh Thiem 《Tropical Medicine and Health》2013,41(3):121-127
Rotavirus is a leading cause of severe diarrhea among children worldwide. Thus, the World Health Organization recommended including rotavirus vaccines in national immunization programs. One concern about rotavirus vaccine, however, is a possible association with intussusception. Thus, it is crucial to know the baseline incidence of intussusception in the first year of life. A study conducted in Hanoi, Vietnam showed that the incidence of intussusception was the highest in the world. This retrospective cross-sectional study was undertaken to determine the incidence of intussusception among children <5 years of age in Nha Trang, Vietnam. Hospital charts between 2009 and 2011 were reviewed in Khanh Hoa Provincial General Hospital where virtually all cases of intussusception occurring in the city were assumed to have been encountered. The incidence of intussusception among children <1 year of age was 296 per 100,000 person-years (95% confidence interval [CI]: 225–382), and that among children <5 years of age was 196 per 100,000 person-years (95% CI: 169–226), confirming the high incidence of intussusception in Vietnam. Nevertheless, there was no intussusception in the first three months of life. We therefore recommend that the first dose of any rotavirus vaccine be administered to infants between 6 and 12 weeks of age. 相似文献
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