全文获取类型
收费全文 | 406072篇 |
免费 | 29737篇 |
国内免费 | 5506篇 |
专业分类
耳鼻咽喉 | 4697篇 |
儿科学 | 10150篇 |
妇产科学 | 9078篇 |
基础医学 | 54721篇 |
口腔科学 | 9023篇 |
临床医学 | 39589篇 |
内科学 | 79221篇 |
皮肤病学 | 6165篇 |
神经病学 | 33536篇 |
特种医学 | 13657篇 |
外国民族医学 | 24篇 |
外科学 | 57934篇 |
综合类 | 17096篇 |
现状与发展 | 11篇 |
一般理论 | 352篇 |
预防医学 | 33377篇 |
眼科学 | 10393篇 |
药学 | 31607篇 |
61篇 | |
中国医学 | 4018篇 |
肿瘤学 | 26605篇 |
出版年
2023年 | 2197篇 |
2022年 | 4013篇 |
2021年 | 8764篇 |
2020年 | 5848篇 |
2019年 | 7652篇 |
2018年 | 8904篇 |
2017年 | 7018篇 |
2016年 | 7390篇 |
2015年 | 9251篇 |
2014年 | 12818篇 |
2013年 | 16531篇 |
2012年 | 24770篇 |
2011年 | 25970篇 |
2010年 | 15224篇 |
2009年 | 13378篇 |
2008年 | 21948篇 |
2007年 | 23016篇 |
2006年 | 22735篇 |
2005年 | 22103篇 |
2004年 | 20162篇 |
2003年 | 18707篇 |
2002年 | 17368篇 |
2001年 | 9442篇 |
2000年 | 9113篇 |
1999年 | 8638篇 |
1998年 | 5264篇 |
1997年 | 4310篇 |
1996年 | 3389篇 |
1995年 | 3250篇 |
1994年 | 2757篇 |
1993年 | 2479篇 |
1992年 | 5116篇 |
1991年 | 5104篇 |
1990年 | 4662篇 |
1989年 | 4619篇 |
1988年 | 4459篇 |
1987年 | 4284篇 |
1986年 | 4095篇 |
1985年 | 3962篇 |
1984年 | 3282篇 |
1983年 | 2925篇 |
1982年 | 2355篇 |
1981年 | 2135篇 |
1980年 | 1920篇 |
1979年 | 2616篇 |
1978年 | 1931篇 |
1975年 | 1659篇 |
1974年 | 1826篇 |
1973年 | 1810篇 |
1972年 | 1699篇 |
排序方式: 共有10000条查询结果,搜索用时 187 毫秒
1.
Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality are
increasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnostic
methods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent.
Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography
(UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measure
the expression levels of miR-144-5p and miR-26b-5p in the plasma of patients with BC. The receiver operating characteristics (ROC) curve and area under the curve (AUC) were used to investigate the potential diagnostic value of miR-
144-5p, miR-26b-5p and the elastographic score in BC. Results: The ultrasonic elastography score(UES) was found to
be significantly upregulated in BC compared with that in benign breast lesions, and the AUC, sensitivity and specificity
were 0.809, 0.717 and 0.806 for distinguishing BC from benign breast lesions, respectively. miR-144-5p and miR-26b-
5p were found to be upregulated in the plasma of BC patients, and miR-144-5p+miR-26b-5p had 0.781 sensitivity and
0.780 specificity for the diagnosis of BC. Furthermore, we found that the diagnostic performance of miR-144-5p and
miR-26b-5p combined with UES for BC had 0.913 sensitivity and 0.890 specificity. Conclusions: The combination of
plasma miR-144-5p, miR-26b-5p and UES has a very high clinical application value for the early detection of BC. 相似文献
2.
3.
Qian Zhang Larry D. Mesner Gina M. Calabrese Naomi Dirckx Zhu Li Angela Verardo Qian Yang Robert J. Tower Marie-Claude Faugere Charles R. Farber Thomas L. Clemens 《The Journal of clinical investigation》2021,131(7)
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/microtubule affinity regulating kinase 3 (MARK3), a conserved serine/threonine kinase known to regulate bioenergetics, cell division, and polarity. Mice lacking Mark3 either globally or selectively in osteoblasts have increased bone mass at maturity. RNA profiling from Mark3-deficient osteoblasts suggested changes in the expression of components of the Notch signaling pathway. Mark3-deficient osteoblasts exhibited greater matrix mineralization compared with controls that was accompanied by reduced Jag1/Hes1 expression and diminished downstream JNK signaling. Overexpression of Jag1 in Mark3-deficient osteoblasts both in vitro and in vivo normalized mineralization capacity and bone mass, respectively. Together, these findings reveal a mechanism whereby genetically regulated alterations in Mark3 expression perturb cell signaling in osteoblasts to influence bone mass. 相似文献
4.
5.
6.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
7.
目的 探讨滋肾育胎丸加减方预防抗磷脂抗体(ACA)阳性者不良妊娠结局的效果及机制研究。方法 选取2016年2月至2019年2月我院收治的89例ACA阳性,先兆性流产或有习惯性流产(RSA)史患者,将采用西医治疗的40例作为对照组,将采用西医联合滋肾育胎丸加减方治疗的49例作为观察组,比较两组中医证候疗效、中医证候积分、ACA-IgA、ACA-IgM、ACA-IgG、凝血指标[血小板聚集功能(PAF)、活化蛋白C(PC)、抗凝血酶(AT)、纤溶酶原激活抑制物-1(PAI-1)]、Th1/Th2细胞因子[干扰素γ(IFN-γ)、白介素-2(IL-2)、白介素-4(IL-4)、白介素-10(IL-10)]、妊娠结局、安全性。结果 治疗2周后检测ACA,观察组2例未降低,对照组11例未降低,观察组未降低患者占比低于对照组(P<0.05);观察组总有效率100.00%高于对照组85.00%(P<0.05);观察组治疗4周、7周后中医证候积分低于对照组(P<0.05);观察组治疗4周、7周后ACA-IgA、ACA-IgM、ACA-IgG低于对照组(P<0.05);观察组治疗4周、7周后PAF、PAI-1低于对照组,PC、AT高于对照组(P<0.05);观察组治疗4周、7周后IFN-γ、IL-2低于对照组,IL-4、IL-10高于对照组(P<0.05);观察组活产率95.92%高于对照组80.00%(P<0.05);组间不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 动态监测ACA对滋肾育胎丸加减方精准应用具有指导意义,指导滋肾育胎丸加减方通过调理脏腑、气血、经络功能,改善先兆性流产或有RSA史患者临床症状及凝血因子指标,降低ACA水平,并可改善患者免疫耐受功能,提高胎儿活产率,且安全性高。 相似文献
8.
9.
10.