全文获取类型
收费全文 | 18712篇 |
免费 | 1250篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 344篇 |
儿科学 | 512篇 |
妇产科学 | 281篇 |
基础医学 | 2575篇 |
口腔科学 | 470篇 |
临床医学 | 1609篇 |
内科学 | 3915篇 |
皮肤病学 | 377篇 |
神经病学 | 1568篇 |
特种医学 | 1089篇 |
外国民族医学 | 10篇 |
外科学 | 3030篇 |
综合类 | 142篇 |
一般理论 | 2篇 |
预防医学 | 1256篇 |
眼科学 | 386篇 |
药学 | 1166篇 |
中国医学 | 30篇 |
肿瘤学 | 1246篇 |
出版年
2022年 | 109篇 |
2021年 | 368篇 |
2020年 | 219篇 |
2019年 | 295篇 |
2018年 | 381篇 |
2017年 | 302篇 |
2016年 | 391篇 |
2015年 | 406篇 |
2014年 | 517篇 |
2013年 | 637篇 |
2012年 | 983篇 |
2011年 | 1005篇 |
2010年 | 564篇 |
2009年 | 547篇 |
2008年 | 898篇 |
2007年 | 876篇 |
2006年 | 870篇 |
2005年 | 887篇 |
2004年 | 799篇 |
2003年 | 751篇 |
2002年 | 724篇 |
2001年 | 624篇 |
2000年 | 605篇 |
1999年 | 532篇 |
1998年 | 222篇 |
1997年 | 176篇 |
1996年 | 166篇 |
1995年 | 138篇 |
1994年 | 136篇 |
1993年 | 128篇 |
1992年 | 329篇 |
1991年 | 305篇 |
1990年 | 325篇 |
1989年 | 304篇 |
1988年 | 265篇 |
1987年 | 250篇 |
1986年 | 232篇 |
1985年 | 223篇 |
1984年 | 196篇 |
1983年 | 158篇 |
1982年 | 107篇 |
1979年 | 157篇 |
1978年 | 118篇 |
1977年 | 92篇 |
1976年 | 93篇 |
1975年 | 116篇 |
1974年 | 106篇 |
1973年 | 102篇 |
1970年 | 96篇 |
1969年 | 94篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
ABSTRACTThis work collates data from the analysis of complex mixtures analysed in STRmix during routine no-suspect volume crime work. It interrogates the upload rate for these types of mixtures and which component of the profile has been able to be interpreted for upload. The number of profiles giving multiple uploads and the amount of replicate PCR analysis has been collated. 相似文献
3.
The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to control the disease are undermined by the growing threat posed by drug resistance. This review covers the historical background of studies on the structure and function of HIV protease, the subsequent development of antiviral inhibitors, and recent studies on drug-resistant protease variants. We highlight the important contributions of Dr. Stephen Oroszlan to fundamental knowledge about the function of the HIV protease and other retroviral proteases. These studies, along with those of his colleagues, laid the foundations for the design of clinical inhibitors of HIV protease. The drug-resistant protease variants also provide an excellent model for investigating the molecular mechanisms and evolution of resistance. 相似文献
4.
5.
Vincent Laville Sigrid Le Clerc Khaled Ezzedine Randa Jdid Lieng Taing Toufik Labib Cdric Coulonges Damien Ulveling Pilar Galan Christiane Guinot Leopold Fezeu Frdrique Morizot Julie Latreille Denis Malvy Erwin Tschachler Jean‐Franois Zagury 《Experimental dermatology》2019,28(8):892-898
Sagging eyelid is considered as an outward of skin ageing and may cause medical issues. However, little is known about the factors involved in sagging eyelid. The study, which aims at determining genetic risk factors for eyelid sagging, was conducted in a cohort of 502 unrelated Caucasian women living in the Paris region. All included participants were aged between 44 and 70 years old (mean age, 57.6 years old). The severity of sagging eyelid was graded in 6 categories by a dermatologist using standardized photographs of the face. A genome wide association study adjusted on potential risk factors (including age and smoking habits) was conducted to identify genetic associations. Two single nucleotide polymorphisms in total linkage disequilibrium on chromosome 10, rs16927253 (P = 7.07 × 10‐10) and rs4746957 (P = 1.06 × 10‐8), were significantly associated with eyelid sagging severity. The rs16927253‐T and rs4746957‐A alleles showed a dominant protective effect towards eyelid sagging. These polymorphisms are located in intronic parts of the H2AFY2 gene which encodes a member of the H2A histone family and very close to the AIFM2 gene that induces apoptosis. Additionally, single nucleotide polymorphisms with a false discovery rate below 0.25 were located nearby the type XIII collagen COL13A1 gene on chromosome 10 and in the ADAMTS18 gene on chromosome 16. Several relevant genes were identified by the genome wide association study for their potential role in the sagging eyelid severity. 相似文献
6.
7.
8.
9.
Dr. R. Hinrichs L. Weber K. Scharffetter-Kochanek 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》2006,57(5):455-458
Ohne Zusammenfassung 相似文献
10.
Susan M Domchek Andrea Eisen Kathleen Calzone Jill Stopfer Anne Blackwood Barbara L Weber 《Journal of clinical oncology》2003,21(4):593-601
Breast cancer risk assessment provides an estimation of disease risk that can be used to guide management for women at all levels of risk. In addition, the likelihood that breast cancer risk is due to specific genetic susceptibility (such as BRCA1 or BRCA2 mutations) can be determined. Recent developments have reinforced the clinical importance of breast cancer risk assessment. Tamoxifen chemoprevention as well as prevention studies such as the Study of Tamoxifen and Raloxifene are available to women at increased risk of developing breast cancer. In addition, specific management strategies are now defined for BRCA1 and BRCA2 mutation carriers. Risk may be assessed as the likelihood of developing breast cancer (using risk assessment models) or as the likelihood of detecting a BRCA1 or BRCA2 mutation (using prior probability models). Each of the models has advantages and disadvantages, and all need to be interpreted in context. We review available risk assessment tools and discuss their application. As illustrated by clinical examples, optimal counseling may require the use of several models, as well as clinical judgment, to provide the most accurate and useful information to women and their families. 相似文献