排序方式: 共有15条查询结果,搜索用时 15 毫秒
1.
Carlo de Olim Denis Bégin Louis-Philippe Boulet André Cartier Michel Gérin Catherine Lemière 《Canadian respiratory journal》2015,22(6):341-347
BACKGROUND:
Specific inhalation challenges (SIC) enable the identification of the agent responsible of occupational asthma (OA). A clinician may fail to identify a specific agent in the workplace, which may potentially lead to a misdiagnosis. The expert assessment method performed by an occupational hygienist has been used to evaluate occupational exposures in epidemiological studies.OBJECTIVE:
The broad aim of the present study was to evaluate the contribution of an expert assessment performed by an occupational hygienist to the diagnosis of OA. The specific aim was to compare work-place exposures identified by an occupational hygienist and by chest physicians in subjects with positive SICs and subjects with asthma, but with a negative SIC.METHODS:
SICs were performed in 120 cases: 67 were positive and 53 were negative. A clinician assessed occupational exposures to sensitizers during a routine clinical evaluation preceding the performance of the SIC. An expert assessment of occupational exposures was performed by an occupational hygienist blind to the result of the SIC.RESULTS:
The occupational hygienist identified the causal agent in 96.7% of the 61 cases of positive SIC. In 33 (62.3%) cases of negative SICs, the occupational hygienist identified ≥1 sensitizing agent(s) that had not been identified by the clinician.CONCLUSION:
The hygienist identified the causal agent in almost all subjects with OA. In contrast, the clinician failed to identify potential exposures to sensitizers in >60% of the negative SIC subjects, which may have resulted in some subjects being misdiagnosed as not having OA. 相似文献2.
Grace?BauhahnEmail author Harald?Veen Rigo?Hoencamp Nelson?Olim Edward?C.?T.?H.?Tan 《World journal of surgery》2017,41(9):2200-2206
Introduction
Malunion is a well-recognized complication of long-bone fractures which accounts for more than 25% of injuries in conflict zones. The aim of this study was to investigate the rate of malunion sustained by casualties with penetrating gunshot wounds in an International Committee of the Red Cross (ICRC) surgical substitution project in the Democratic Republic of Congo (DRC) and compare these results with current literature.Methods
A retrospective cohort study was performed. All patients admitted to the ICRC facility between the periods of 01.10.2014 and 31.12.2015 with long-bone fractures caused by gunshot wound were included, and data were collected retrospectively from the patient’s hospital notes.Results
A total of 191 fractures caused by gunshot were treated in the DRC at the ICRC surgical substitution project during the study period. On average, the fractures were 3 days old on admission and were all open, with 62% also being comminuted. The ICRC management protocol, which emphasizes debridement, antibiotic prophylaxis and conservative fracture stabilization, was followed in all cases. Forty-eight percentage of the fractures were finally classified as ‘union without complication’; however, 17% were classified as ‘malunion’.Conclusions
This study indicates that open long-bone fractures that are managed by the ICRC surgical substitution project in DRC may have an increased likelihood of malunion as compared to long-bone fractures treated in developed countries. Patient delay and mechanism of injury may have caused increased rates of infection which are likely behind these increased rates of malunion, alongside the lack of definitive fracture treatment options made available to the surgical team.3.
M C Martins G Olim J Melo H A Magalh?es M O Rodrigues 《Journal of medical genetics》1993,30(3):235-239
A countrywide prospective study aimed at establishing the prevalence of the haemoglobinopathy genes in the Portuguese population was carried out by screening 15,208 randomly selected blood samples from young males. This male based survey provided the opportunity of assessing simultaneously the prevalence of the red cell enzyme glucose-6-phosphate dehydrogenase (G6PD) deficiency, thus giving a picture of these important hereditary anaemias in Portugal. The results showed a low average frequency of beta thalassaemia (0.45%) and haemoglobin S (0.32%) carriers as well as G6PD deficiency (0.51%). However, these disorders are unevenly distributed throughout the country with a higher prevalence in some areas, mainly in the south. The relationship of this pattern of haemoglobinopathies to the known haplotypes linked to beta thalassaemia and sickle cell disease, relevant historical events, and local selective pressure was investigated. Hb D and Hb J are the commonest other structural variants. The implemented programme for control of these hereditary anaemias is described. 相似文献
4.
Enrique Gutirrez Irving Snchez Omar Díaz Adrin Valles Ricardo Balderrama Jesús Fuentes Brenda Lara Cipatli Olimn Víctor Ruiz Jos Rodríguez Luis H. Bayardo Matthew Chan Conrad J. Villafuerte Jerusha Padayachee Alexander Sun 《Current oncology (Toronto, Ont.)》2021,28(4):2560
Lung metastases are the second most common malignant neoplasms of the lung. It is estimated that 20–54% of cancer patients have lung metastases at some point during their disease course, and at least 50% of cancer-related deaths occur at this stage. Lung metastases are widely accepted to be oligometastatic when five lesions or less occur separately in up to three organs. Stereotactic body radiation therapy (SBRT) is a noninvasive, safe, and effective treatment for metastatic lung disease in carefully selected patients. There is no current consensus on the ideal dose and fractionation for SBRT in lung metastases, and it is the subject of study in ongoing clinical trials, which examines different locations in the lung (central and peripheral). This review discusses current indications, fractionations, challenges, and technical requirements for lung SBRT. 相似文献
5.
An Azorean family with Hb H disease (10% Hb H) was studied in order to elucidate its molecular basis. DNA studies on the patient only revealed a 4.2 kb "leftward" deletion of paternal origin which implies the co-inheritance of a nondeletional alpha-thalassemia determinant. Restriction endonuclease and oligonucleotide analysis allowed the exclusion of five point mutations: initiation codon (at both alpha 1- and alpha 2-globin genes), IVS-I donor splice junction pentanucleotide deletion, codon 125 CTG----CCG substitution, and Saudi Arabian polyadenylation signal mutation. These findings suggest that the molecular basis of this form of Hb H disease is probably different from those described previously. 相似文献
6.
7.
Occult hepatitis B infection in blood donors 总被引:2,自引:0,他引:2
Reesink HW Engelfriet CP Henn G Mayr WR Delage G Bernier F Krusius T Assal A Gallian P Corbi C Morel P David B De Micco P Murokawa H Yugi H Hino S Tadokoro K Flesland O Brojer E Letowska M Olim G Nascimento F Gonçalves H Castro L Morais M Stezinar SL Alvarez M Sauleda S González R Niederhauser C Stolz M Allain JP Owusu-Ofori S Eglin R Stramer S Busch M Strong DM Epstein J Biswas R 《Vox sanguinis》2008,94(2):153-166
8.
Rodrigues MO Pereira JD Gaspar G Olim G Martins MD Monteiro C 《Journal of clinical laboratory analysis》2004,18(2):129-131
In Portugal there are a wide variety of G6PD deficiency associated mutations. In an individual from the island of Flores of the Azorean archipelago, we report a new mutation in the G6PD gene that gives rise to a "moderate rate of G6PD deficiency" (12.6% of the normal activity) according to WHO criteria. Direct sequencing revealed a C-->A point mutation at position 1387 with the consequent substitution of an Argine by Serine. We designated this new mutation as G6PD FLORES. The mutation is associated with haplotype I ( - - + + - - ), using six intragenic RFLPs. This information may also be seen as contributing to the clarification of the genetic makeup of the Azorean population, founder mutations, and/or gene flow. 相似文献
9.
Gouveia LO Castanho P Ferreira JJ Guedes MM Falcão F e Melo TP 《Clinical neurology and neurosurgery》2007,109(10):922-925
Chiropractic's popularity is rising among the general population. Moreover, few studies have been conducted to properly evaluate its safety. We report three cases of serious neurological adverse events in patients treated with chiropractic manipulation. The first case is a 41 years old woman who developed a vertebro-basilar stroke 48 h after cervical manipulation. The second case represents a 68 years old woman who presented a neuropraxic injury of both radial nerves after three sessions of spinal manipulation. The last case is a 34 years old man who developed a cervical epidural haematoma after a chiropractic treatment for neck pain.
In all three cases there were criteria to consider a causality relation between the neurological adverse events and the chiropractic manipulation. The described serious adverse events promptly recommend the implementation of a risk alert system. 相似文献
10.
Luis A Torres-Reyes Liliana Alvarado-Ruiz Patricia Pi?a-Sánchez María G Martínez-Silva Moisés Ramos-Solano Vicente Olimón-Andalón Pablo C Ortiz-Lazareno Georgina Hernández-Flores Alejandro Bravo-Cuellar Adriana Aguilar-Lemarroy Luis F Jave-Suarez 《International journal of clinical and experimental pathology》2014,7(11):7409-7418