全文获取类型
收费全文 | 751篇 |
免费 | 42篇 |
国内免费 | 59篇 |
专业分类
儿科学 | 44篇 |
妇产科学 | 6篇 |
基础医学 | 37篇 |
口腔科学 | 13篇 |
临床医学 | 130篇 |
内科学 | 219篇 |
皮肤病学 | 17篇 |
神经病学 | 12篇 |
特种医学 | 229篇 |
外科学 | 32篇 |
综合类 | 27篇 |
预防医学 | 24篇 |
眼科学 | 8篇 |
药学 | 30篇 |
中国医学 | 2篇 |
肿瘤学 | 22篇 |
出版年
2022年 | 3篇 |
2021年 | 9篇 |
2020年 | 3篇 |
2019年 | 3篇 |
2018年 | 12篇 |
2017年 | 3篇 |
2016年 | 2篇 |
2015年 | 13篇 |
2014年 | 13篇 |
2013年 | 23篇 |
2012年 | 9篇 |
2011年 | 8篇 |
2010年 | 20篇 |
2009年 | 20篇 |
2008年 | 11篇 |
2007年 | 44篇 |
2006年 | 5篇 |
2005年 | 12篇 |
2004年 | 10篇 |
2003年 | 9篇 |
2002年 | 5篇 |
2001年 | 8篇 |
2000年 | 5篇 |
1999年 | 11篇 |
1998年 | 51篇 |
1997年 | 35篇 |
1996年 | 59篇 |
1995年 | 44篇 |
1994年 | 40篇 |
1993年 | 49篇 |
1992年 | 9篇 |
1991年 | 10篇 |
1990年 | 18篇 |
1989年 | 27篇 |
1988年 | 33篇 |
1987年 | 34篇 |
1986年 | 25篇 |
1985年 | 29篇 |
1984年 | 16篇 |
1983年 | 10篇 |
1982年 | 12篇 |
1981年 | 22篇 |
1980年 | 19篇 |
1979年 | 6篇 |
1978年 | 9篇 |
1977年 | 15篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1970年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有852条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Short-Ti inversion-recovery pulse sequence: analysis and initial experience in cancer imaging 总被引:2,自引:0,他引:2
Inversion recovery (IR), commonly considered a pulse sequence capable of producing T1-weighted images with excellent display of normal anatomy, is versatile: The null point and peak time provide a useful, succinct summary of the properties of IR and its capacity for producing both T1- and T2-weighted images. Shortening of the inversion time (TI) and creation of a short-TI inversion-recovery (STIR) pulse sequence increases sensitivity to malignancy and other abnormalities by making the effects of prolonged T1 and T2 on signal intensity additive and by nulling the signal from fat. The authors examined over 300 patients with various malignancies and compared STIR images with T1- and T2-weighted images obtained at 0.5 T. In 43 cases, signal-difference-to-noise ratios (SD/Ns) were calculated between tumor, fat, and muscle. In general, STIR images demonstrated tumor as a conspicuously high-intensity area in a background of muted, discernible anatomic detail. The good contrast achieved with STIR sequences between tumor and fat (SD/N = 18.1) and tumor and muscle (SD/N = 12.9) consolidated into a single image the information contained separately on T1- and T2-weighted images, which facilitates efficient detection and localization of malignancy. 相似文献
6.
Sixteen cases of histopathologically proved solitary rectal ulcer syndrome were encountered. Fifteen patients underwent barium enema study; in nine cases the findings--including rectal stricture, granularity of the mucosa, and thickened rectal folds-were nonspecific. In six cases the study was normal. All patients had a long history of defecation disorders, and defecography was performed in all. In seven cases, intussusception of the rectal wall was seen; in another case the intussusception was accompanied by a rectocele. One case showed rectal prolapse. In four cases, failed relaxation of the puborectalis occurred and prevented the passage of the bolus; in another case there was abnormal perineal descent. In two patients studies were normal. In patients with defecation disorders, the possibility of this syndrome should be considered. Defecography is the method of choice for establishing the diagnosis. 相似文献
7.
I B Taraporewala J W Cessac T C Chanh A V Delgado R F Schinazi 《Journal of medicinal chemistry》1992,35(15):2744-2752
The antiviral/antitumor marine alkaloid dercitin was used as a lead compound to design analogues with anti-HIV and tumor inhibitory activities. Deletion of structural features contributing to cytotoxicity led to analogues with lowered T-lymphocyte toxicity profiles. One compound, 5, induced complete protection against HIV-1 infectivity in vitro at 12.5 micrograms/mL (38 microM) without T-cell toxicity up to 400 micrograms/mL. Compound 4 and 5 also inhibited the binding of HIV-1 to H-9 lymphocytes. These compounds may exert antiviral activity by a unique dual extracellular and intracellular mode of action--both preventing viral attachment to lymphocytes as well as intercalating with viral nucleic acid. Analogues with higher cytotoxicity such as 2 which retain the thiazole ring of the natural product proved effective in completely inhibiting the cell proliferation of breast, colon, and lung tumor cell lines at 1.5 microM concentration compared to a 70 microM dose level of 5-fluorouracil. A means of molecular separation of antiviral activity from cytotoxicity was thus achieved, and putative pharmacophores for antiviral and antitumor actions of the prototype molecule dercitin have been deduced. The 2-thio-9-acridinone derivatives 4 and 5 represent a new structural type exhibiting activity against HIV in vitro, serving as chemical leads in the design of anti-AIDS agents, while thiazolo[5,4-b]acridines such as 2 provide leads in the drug design of new antitumor agents. 相似文献
8.
9.
10.