全文获取类型
收费全文 | 3417篇 |
免费 | 374篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 240篇 |
妇产科学 | 58篇 |
基础医学 | 480篇 |
口腔科学 | 58篇 |
临床医学 | 291篇 |
内科学 | 734篇 |
皮肤病学 | 38篇 |
神经病学 | 209篇 |
特种医学 | 652篇 |
外科学 | 338篇 |
综合类 | 63篇 |
一般理论 | 1篇 |
预防医学 | 237篇 |
眼科学 | 29篇 |
药学 | 174篇 |
中国医学 | 7篇 |
肿瘤学 | 191篇 |
出版年
2021年 | 33篇 |
2020年 | 29篇 |
2019年 | 30篇 |
2018年 | 42篇 |
2017年 | 43篇 |
2016年 | 40篇 |
2015年 | 55篇 |
2014年 | 59篇 |
2013年 | 105篇 |
2012年 | 85篇 |
2011年 | 110篇 |
2010年 | 118篇 |
2009年 | 100篇 |
2008年 | 103篇 |
2007年 | 106篇 |
2006年 | 98篇 |
2005年 | 99篇 |
2004年 | 78篇 |
2003年 | 94篇 |
2002年 | 86篇 |
2001年 | 83篇 |
2000年 | 96篇 |
1999年 | 92篇 |
1998年 | 180篇 |
1997年 | 140篇 |
1996年 | 152篇 |
1995年 | 110篇 |
1994年 | 91篇 |
1993年 | 104篇 |
1992年 | 75篇 |
1991年 | 76篇 |
1990年 | 73篇 |
1989年 | 118篇 |
1988年 | 94篇 |
1987年 | 102篇 |
1986年 | 84篇 |
1985年 | 77篇 |
1984年 | 60篇 |
1983年 | 47篇 |
1982年 | 43篇 |
1981年 | 34篇 |
1980年 | 54篇 |
1979年 | 40篇 |
1978年 | 29篇 |
1977年 | 31篇 |
1976年 | 35篇 |
1975年 | 37篇 |
1974年 | 17篇 |
1973年 | 20篇 |
1971年 | 13篇 |
排序方式: 共有3815条查询结果,搜索用时 15 毫秒
1.
Uptake of iodine-123 MIBG by pheochromocytomas, paragangliomas, and neuroblastomas: a histopathological comparison 总被引:2,自引:0,他引:2
J Bomanji D A Levison W D Flatman T Horne P M Bouloux G Ross K E Britton G M Besser 《Journal of nuclear medicine》1987,28(6):973-978
The percentage uptake of [123I]metaiodobenzylguanidine (MIBG) by tumors of the paraganglion system is compared with the number of neurosecretory granules (assessed by both light and electron microscopy) in the subsequently resected tumors in six patients. Iodine-123 MIBG was injected intravenously; the tumor uptake of [123I]MIBG varied between 0.001% and 0.14% of the injected dose per gram of tumor tissue at 22 hr. The number of neurosecretory granules in tissue sections was scored on a scale of I-III. A direct proportional correlation was found between the percentage uptake of [123I]MIBG by the tumor and the number of neurosecretory granules in the tissue sections but not with plasma or urinary catecholamines. This technique for imaging reflects the storage status of the tumor better than plasma and urinary catecholamine measurements. 相似文献
2.
The requirements, problems and progress of radioimmunotherapy in the management of certain malignancies are described. The future prospects using a two- or three-stage approach are promising. 相似文献
3.
Israel Liberzon Stephan F Taylor K Luan Phan Jennifer C Britton Lorraine M Fig Joshua A Bueller Robert A Koeppe Jon-Kar Zubieta 《Neuropsychopharmacology》2007,61(9):1030-1038
BACKGROUND: Functional neuroimaging studies have detected abnormal limbic and paralimbic activation to emotional probes in posttraumatic stress disorder (PTSD), but few studies have examined neurochemical mechanisms that underlie functional alterations in regional cerebral blood flow. The mu-opioid neurotransmitter system, implicated in responses to stress and suppression of pain, is distributed in and is thought to regulate the function of brain regions that are implicated in affective processing. METHODS: Here we examined the micro-opioid system with positron emission tomography and the micro-opioid receptor-selective radiotracer [11C] carfentanil in 16 male patients with PTSD and two non-PTSD male control groups, with (n = 14) and without combat exposure (n = 15). Differences in micro-opioid receptor binding potential (BP2) were detected within discrete limbic and paralimbic regions. RESULTS: Relative to healthy controls, both trauma-exposed groups had lower micro-opioid receptor BP2 in extended amygdala, nucleus accumbens, and dorsal frontal and insular cortex but had higher BP2 in the orbitofrontal cortex. PTSD patients exhibited reduced BP2 in anterior cingulate cortex compared with both control groups. Micro-opioid receptor BP2 in combat-exposed subjects without PTSD was lower in the amygdala but higher in the orbitofrontal cortex compared with both PTSD patients and healthy controls. CONCLUSIONS: These findings differentiate the general response of the micro-opioid system to trauma from more specific changes associated with PTSD. 相似文献
4.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
5.
6.
7.
8.
9.
Sylvia Mitchell Veronica A. Bradley John L. Welch Peter G. Britton 《Brain injury : [BI]》1990,4(3):273-279
This study reports on the efficacy of a 'coma arousal procedure'. This procedure involved a programme of vigorous sensory stimulation administered to comatose patients by relatives using Comakits. An experimental group of 12 severely head-injured patients received the coma arousal procedure while a matched control group did not. Total duration of coma and weekly Glasgow Coma Scale Scores were recorded for the two groups. Results indicate that the total duration of coma was significantly shorter and that coma lightened more rapidly for the experimental group. 相似文献
10.