全文获取类型
收费全文 | 1904篇 |
免费 | 113篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 38篇 |
妇产科学 | 48篇 |
基础医学 | 353篇 |
口腔科学 | 17篇 |
临床医学 | 199篇 |
内科学 | 498篇 |
皮肤病学 | 24篇 |
神经病学 | 208篇 |
特种医学 | 47篇 |
外科学 | 191篇 |
综合类 | 7篇 |
一般理论 | 1篇 |
预防医学 | 104篇 |
眼科学 | 21篇 |
药学 | 147篇 |
中国医学 | 3篇 |
肿瘤学 | 95篇 |
出版年
2023年 | 16篇 |
2022年 | 70篇 |
2021年 | 108篇 |
2020年 | 29篇 |
2019年 | 54篇 |
2018年 | 50篇 |
2017年 | 33篇 |
2016年 | 50篇 |
2015年 | 61篇 |
2014年 | 83篇 |
2013年 | 70篇 |
2012年 | 127篇 |
2011年 | 134篇 |
2010年 | 81篇 |
2009年 | 61篇 |
2008年 | 129篇 |
2007年 | 118篇 |
2006年 | 116篇 |
2005年 | 105篇 |
2004年 | 89篇 |
2003年 | 85篇 |
2002年 | 83篇 |
2001年 | 26篇 |
2000年 | 19篇 |
1999年 | 12篇 |
1998年 | 14篇 |
1997年 | 11篇 |
1996年 | 17篇 |
1995年 | 14篇 |
1994年 | 14篇 |
1993年 | 9篇 |
1992年 | 11篇 |
1991年 | 9篇 |
1990年 | 12篇 |
1989年 | 12篇 |
1988年 | 9篇 |
1987年 | 4篇 |
1986年 | 10篇 |
1985年 | 6篇 |
1984年 | 9篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1975年 | 5篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1955年 | 3篇 |
排序方式: 共有2033条查询结果,搜索用时 15 毫秒
1.
2.
Wojciech Szychta M.D. Ph.D. Gheorghe Cerin M.D. Ph.D. F.E.S.C. Bogdan Adrian Popa M.D. Armienti Felice M.D. Guido Lanzillo M.D. Ph.D. Marco Diena M.D. Grzegorz Opolski M.D. Ph.D. F.E.S.C. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(6):1040-1043
Sinus venosus atrial septal defect (SV‐ASD) usually coexists with partial anomalous pulmonary vein connection (PAPVC). It is a difficult diagnosis in transthoracic echocardiography (TTE) due to eccentric position of defects. We present a rare case of atypical anatomical variation in PAPVC, which was never described before. Two right pulmonary veins drained into superior vena cava, which overrode SV‐ASD and interatrial septum, a third pulmonary vein into the right atrium. Complete diagnosis could not be set after TTE, nor transesophageal echocardiography, whereas angio‐CT was finally conclusive. This diagnostic approach allowed the surgical planning. 相似文献
3.
Pawe? Reichert Roman Rutowski Krzysztof Zimmer Jerzy Gosk Krzysztof Bogdan Roman Wiacek 《Chirurgia narzadów ruchu i ortopedia polska》2007,72(3):175-179
Purpose of work was estimation of the results of treatment of pseudoarthrosis of the long bone with the method of decortication, with use of autogenic bone depends on kind of pseudoarthrosis and kind of osteosynthesis. In the years 1995-2005 56 patients were treated because of pseudoarthrosis of long bone in our Clinic. Pseudoarthrosis is classified according to Weber-Cech classification. In the methodology of clinical estimation and subjective estimation of the patient Stewart and Hundley and Anderson classification were used. Union was achieved in 51 cases. Time of bone union achievement was 5 months. The results of treatment are depends on morfology of pseudoartrosis and are independs of kind of osteosynthesis. 相似文献
4.
Claude Clément MD Roberto Ruiz MD Bogdan Costa-Foru MD Hubert Nicaise MD 《Annals of vascular surgery》1990,4(3):305-308
Extrinsic compression of the renal artery due to a fibromuscular band originating from the diaphragm was encountered in a 26-year-old patient who had systemic hypertension associated with stenosis and kinking of one of her renal arteries. After surgical decompression, the renal artery assumed a normal expansion with disappearance of hypertension. Six other cases of extrinsic compression of the renal artery have been found in the literature. Surgical treatment is mandatory in all cases because the mechanism that causes the lesion makes percutaneous transluminal angioplasty illusory. 相似文献
5.
6.
Jacek Semenowicz Bogdan Koczy Przemys?aw Czuma Bart?omiej Pijet Tomasz Olszewski Roman Walo 《Chirurgia narzadów ruchu i ortopedia polska》2007,72(1):33-36
The Avantage double mobility press-fit cup was devised by Dr. Bousquet in the 70's to bring reasonable response to a problem of recurrent dislocation after total hip arthroplasty. The cup is attached to the femoral head by a bipolar polyethylene liner. The polyethylene liner moves freely inside a shiny--polished metal cup. The angular range of motion before impingement is increased by the mobility of the liner. The double connection (cup-liner, liner-head) reduces the stress on the metal cup and improve the stability of the prosthesis. The solution has proved to be efficient in reducing dislocation risk and maintains at the same time the appropriate range of motion. Between January 2004 and November 2005, 113 hip arthroplasties in 108 women with use of the double mobility cup were performed. The cemented version of the Avantage cup was inserted in 15 patients (mean age--76.9 years). Uncemented, HA coated implant was used in 98 patients (with mean age of 55 years). The mean follow-up was 20.4 months. No one patient was lost to follow-up. No postoperative dislocation was observed during follow-up. There was no unwanted leg lengthening greater than 1 cm. The Avantage cup may be indicated in any primary total hip arthroplasty especially in those with increased risk of postoperative dislocations. This cup enables a correct balance of the hip without a need of the unwanted lengthening of the leg. 相似文献
7.
A A Timofeev V A Znamenski? T G Vo?tsekhovskaia A I Gorban' N V Bogdan N A Kravets 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》1990,(1):37-38
The use for local treatment in 45 patients with abscesses and phlegmons of lysozyme immobilized in polymethylsiloxane contributed to acceleration in wound cleaning of necrotic masses, active granulation and epithelization, reduction in duration of patients' treatment by 3-5 days. 相似文献
8.
Ljiljana Ševaljević Sanja Marinković Desanka Bogojević Svetlana Matić Bogdan Bošković 《Archives of toxicology》1989,63(5):406-411
We have studied the effect of soman intoxication on serum acute phase reactants (APR) levels, and the relationship of the APR and corticosterone concentrations and the immunosuppressive activity of the serum. One day after the injection of 1.8 LD50 soman the concentrations of 2-macroglobulin (2-MG) and 1-acid glycoprotein (AGP) in the serum of antidote protected rats increased 4- and 7-fold, respectively, whereas those of hemopexin (Hx), haptoglobin (Hp) and cysteine protease inhibitor (CPI) were two to three times higher than in the controls. A similar magnitude of increase of serum acute phase reactants levels was observed when 0.3 LD50 soman was administered at 24-h intervals over the 5-day period. The relationship of changes in the APR concentration, corticosterone level and immunosuppressive activity of the serum was also comparable to that observed in the acute phase response to tissue injury. 相似文献
9.
Amuzescu B Segal A Flonta ML Simaels J Van Driessche W 《Pflügers Archiv : European journal of physiology》2003,446(1):69-77
Zn(2+) (1-1,000 microM) applied to the apical side of polarized A6 epithelia inhibits Na(+) transport, as reflected in short-circuit current and conductance measurements. The Menten equilibrium constant for Zn(2+) inhibition was 45 microM. Varying the apical Na(+) concentration, we determined the equilibrium constant of the short-circuit current saturation (34.9 mM) and showed that Zn(2+) inhibition is non-competitive. A similar effect was observed in Xenopus oocytes expressing alphabetagammarENaC (alpha-, beta-, and gamma-subunits of the rat epithelial Na(+) channel) in the concentration range of 1-10 microM Zn(2+), while at 100 microM Zn(2+) exerted a stimulatory effect. The analysis of the voltage dependence of the steady-state conductance revealed that the inhibitory effect of Zn(2+) was due mainly to a direct pore block and not to a change in surface potential. The equivalent gating charge of ENaC, emerging from these data, was 0.79 elementary charges, and was not influenced by Zn(2+). The stimulatory effect of high Zn(2+) concentrations could be reproduced by intra-oocyte injection of Zn(2+) (approximately 10 microM), which had no direct effect on the amiloride-sensitive conductance, but switched the effect of extracellular Zn(2+) from inhibition to activation. 相似文献
10.
Interaction of Dr adhesin with collagen type IV is a critical step in Escherichia coli renal persistence
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Selvarangan R Goluszko P Singhal J Carnoy C Moseley S Hudson B Nowicki S Nowicki B 《Infection and immunity》2004,72(8):4827-4835
The pathogenic mechanism of recurrent or chronic urinary tract infection is poorly understood. Escherichia coli cells bearing Dr fimbriae display unique tropism to the basement membrane (BM)-renal interstitium that enables the bacteria to cause chronic pyelonephritis in experimental mice. The renal receptors for Dr-fimbriated E. coli are type IV collagen and decay-accelerating factor (DAF). We hypothesized that type IV collagen receptor-mediated BM-interstitial tropism is essential for E. coli to cause chronic pyelonephritis. To test the role of the type IV collagen tropism of Dr-fimbriated E. coli in renal persistence, we constructed an isogenic mutant in the DraE adhesin subunit that was unable to bind type IV collagen but retained binding to DAF and examined its virulence in the mouse model. The collagen-binding mutant DrI113T was eliminated from the mouse renal tissues in 6 to 8 weeks, while the parent strain caused persistent renal infection that lasted at least 14 weeks (P < or = 0.02). Transcomplementation with the intact Dr operon restored collagen-binding activity, BM-interstitial tropism, and the ability to cause persistent renal infection. We conclude that type IV collagen binding mediated by DraE adhesin is a critical step for the development of persistent renal infection in a murine model of E. coli pyelonephritis. 相似文献