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Shobha Narahari Abida Juwle Subhankar Basak Dhananjaya Saranath 《Infection, genetics and evolution》2009,9(4):643-645
Viral hepatitis represents a major global health problem with 170 million Hepatitis C Virus (HCV) carriers worldwide, and 12–13 million HCV carriers in India. HCV genotypes are of clinical significance in indicating drug responsiveness and prognosis of the patient. The HCV genotypes are of epidemiologic significance as well, as they are indicative of transmission route of infection and have not been extensively studied in the Indian context. In the current study, HCV genotyping was examined in 2118 patients from different geographic regions of India. HCV was detected by PCR amplification of 5′ UTR and core-envelope1 regions, followed by genotyping using nucleotide sequencing and analysis with NCBI tool (http://www.ncbi.nlm.nih.gov/projects/genotyping/formpage.cgi). HCV genotype distribution in the 2118 Indian patients demonstrated prevalence of HCV3 (3a/3b primarily) in 62% and HCV1 (1a/1b primarily) in 31% patients. The predominance of HCV3 was significant in northern (p = 0.01) and eastern (p = 0.008) regions of India. HCV types 2, 4, 5, and 6 were detected in 0.05–4.5% of the patient group. Thus, our studies demonstrate HCV genotype prevalence in the cohort group in different regions of India. 相似文献
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BACKGROUND: Middle ear pathology, either otitis media with effusion or
tubal dysfunction, is frequently seen in day-care centre children.
Recognition and early treatment of this condition is crucial to the
prevention of chronic otitis media, which is a major cause of hearing loss
in later life. OBJECTIVES: We aimed to reveal the incidence of silent
otitis media in day-care centre children and to determine the predisposing
factors, risk factors and the awareness of the parents of the middle ear
disease of their children. METHOD: Two hundred and thirteen children, aged
3-6 years, were screened in four daycare centres. A questionnaire was
prepared that would reveal the predisposing factors. Information was
gathered from both the parents and teachers. Children were examined by
otoscopy, pneumotoscopy, tympanometry and X-rays for sinus pathology.
RESULTS: Forty-three of 213 children had middle ear pathology; 39 of them
were confirmed by tympanometry; 56.1 % of children had some degree of sinus
pathology. We revealed that, although most of the children do not have the
risk factors, they develop middle ear pathology. Among the parents, 81.4%
of them were unaware of the condition. CONCLUSION: Early diagnosis of
middle ear pathologies is necessary for prevention of future complications.
In early stages the condition is silent. We emphasize the importance of the
primary care physician's role in diagnosing the early stages of middle ear
pathologies and recommend that teaching of otoscopic and pneumotoscopic
skills should be part of the training for family physicians.
相似文献
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Bulent Urman Cengiz Alatas Senai Aksoy Alp Nuhoglu Aycan Sertac Basak Balaban 《Journal of assisted reproduction and genetics》1998,15(3):125-128
Purpose:
Our purpose was to determine the feasibility and efficacy of performing testicular or epididymal sperm retrieval prior to the injection of human chorionic gonadotropin (hCG).
Methods:
This report deals with 87 sperm-positive percutaneous epididymal sperm aspiration (PESA), percutaneous testicular sperm aspiration (PTSA), or testicular sperm extraction (TESE) cycles. All sperm retrieval procedures were performed prior to administration of hCG to the women. Retrieved spermatozoa were cultured in vitro in simple medium for approximately 40 hr prior to intracyto-plasmic sperm injection.
Results:
In all but one cycle in which TESE was performed for nonobstructive azoospermia, motile sperm were available for ICSI. The overall fertilization rate was 53%. Pregnancy rate per transfer and implantation rate per embryo were 41.2 and 15.7%, respectively.
Conclusions:
Satisfactory fertilization and pregnancy rates can be achieved when PESA, PTSA, or TESE is performed prior to the injection of hCG followed by in vitro culture of spermatozoa approximately 40 hr before ICSI. Scheduling of testicular or epididymal sperm retrieval cases in this way appears to ease the workload on laboratory and operating room personnel. Furthermore, withholding hCG when sperm is absent may obviate the unnecessary risk of ovarian hyperstimulation when spermatozoa cannot be retrieved. 相似文献
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Risk of tuberculous infection among healthcare workers in a tertiary-care hospital in Ankara, Turkey. 总被引:1,自引:0,他引:1
Ramazan Keskiner Onder Erg?nül Ziya Demiroglu Sebnem Eren Nurcan Baykam Basak Dokuzoguz 《Infection control and hospital epidemiology》2004,25(12):1067-1071
OBJECTIVE: To determine risk factors for tuberculin skin test (TST) positivity among healthcare workers (HCWs). DESIGN: Two-step TST was performed in 2002. SETTING: Tertiary-care hospital in Ankara, Turkey. PARTICIPANTS: A sample of 491 hospital HCWs were included. Information related to demographics, profession, work duration, department, and individual and family history of tuberculosis (TB) was obtained by a structured questionnaire. RESULTS: Four hundred eight (83%) had two-step TST positivity. On multivariate analysis, male physicians (relative risk [RR], 1.5; 95% confidence interval [CI95], 1.23-1.69; P = .001), nurses (RR, 1.5; CI95, 1.29-1.66; P = .005), radiology technicians (RR, 1.7; CI95, 1.35-1.73; P = .002), laboratory technicians (RR, 1.6; CI95, 1.3-1.74; P = .007), and male housekeepers (RR, 1.6; (HCWs). CI95, 1.38-1.7; P < .001) had a higher risk than did female physicians. Among laboratory technicians, radiology technicians had the highest TST positivity (85%). HCWs working for less than 1 year (RR, 0.8; CI95, 0.72-0.98; P = .027) had a lower risk of infection. The HCWs having bacille Calmette-Guerin vaccination (RR, 1.12; CI95, 1.08-1.45) had higher TST positivity. CONCLUSION: Male physicians, nurses, and laboratory technicians had increased risk of Mycobacterium tuberculosis infection in this setting, but community exposure likely accounted for most infections. 相似文献
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Neonatal perforated appendicitis in incarcerated inguinal hernia in the differential diagnosis of testis torsion 下载免费PDF全文
Basak Erginel Feryal Gun Soysal Alaaddin Celik Tansu Salman 《Pediatrics international》2017,59(7):831-832
Appendicitis in newborns is uncommon and difficult to diagnose. Reports on neonatal appendicitis subsequent to inguinal hernia incarceration are exceptionally rare. We present the case of a 26‐day‐old infant with perforated appendicitis due to incarceration of a right inguinal hernia, mimicking right testicular torsion. 相似文献
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Renal complications of lipodystrophy: A closer look at the natural history of kidney disease 下载免费PDF全文
Baris Akinci Sadiye Mehtat Unlu Ali Celik Ilgin Yildirim Simsir Sait Sen Banu Nur Fatma Ela Keskin Basak Ozgen Saydam Nilufer Kutbay Ozdemir Banu Sarer Yurekli Bekir Ugur Ergur Melda Sonmez Tahir Atik Atakan Arslan Tevfik Demir Canan Altay Ulku Aybuke Tunc Tugba Arkan Ramazan Gen Erdal Eren Gulcin Akinci Aslihan Arasli Yilmaz Habib Bilen Samim Ozen Aygul Celtik Senay Savas Erdeve Semra Cetinkaya Huseyin Onay Sulen Sarioglu Elif Arioglu Oral 《Clinical endocrinology》2018,89(1):65-75
10.
Agmatine co‐treatment attenuates allodynia and structural abnormalities in cisplatin‐induced neuropathy in rats 下载免费PDF全文
Basak Donertas Cigdem Cengelli Unel Sule Aydin Emel Ulupinar Orhan Ozatik Bilgin Kaygisiz Engin Yildirim Kevser Erol 《Fundamental & clinical pharmacology》2018,32(3):288-296
Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy is a well‐known side effect of cisplatin and has potential to result in limiting and/or reducing the dose, decreasing the quality of life. Thus, effective treatments are needed. Agmatine is an endogenous neuromodulator that has been shown to exert antiallodynic effects in various animal studies. The first aim of this study was to investigate the in vitro effects of agmatine on cisplatin‐induced neurotoxicity. Primary cultures of dorsal root ganglia (DRG) which are the primary target of drug injury were prepared. DRG cells were incubated with cisplatin (100, 200, 500 μm ). Then, agmatine (10, 100, 500 μm ) was administered with the submaximal concentration of cisplatin. Cisplatin caused concentration‐dependent neurotoxicity, and agmatine did not alter this effect. The second aim was to investigate the effects of agmatine on cisplatin‐induced peripheral neuropathy in rats and the influence of nitric oxide synthase (NOS) inhibitor, L‐NAME, in this effect. Female Sprague Dawley rats received intraperitoneal saline (control), cisplatin (3 mg/kg), cisplatin+agmatine (100 mg/kg), or cisplatin+agmatine+L‐NAME (10 mg/kg) once a week for 5 weeks. The mechanical allodynia, hot plate, and tail clip tests were performed, and DRG cells and sciatic nerves were analyzed. Agmatine and agmatine+L‐NAME combination attenuated CIS‐induced mechanical allodynia and degeneration in DRG cells and sciatic nerves. However, L‐NAME did not potentiate the antiallodynic or neuroprotective effect of agmatine. These findings indicate that agmatine co‐administration ameliorates cisplatin‐induced neuropathy and may be a therapeutic alternative. 相似文献