全文获取类型
收费全文 | 3711篇 |
免费 | 248篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 96篇 |
妇产科学 | 40篇 |
基础医学 | 508篇 |
口腔科学 | 114篇 |
临床医学 | 296篇 |
内科学 | 915篇 |
皮肤病学 | 106篇 |
神经病学 | 262篇 |
特种医学 | 194篇 |
外科学 | 487篇 |
综合类 | 19篇 |
一般理论 | 3篇 |
预防医学 | 189篇 |
眼科学 | 50篇 |
药学 | 250篇 |
中国医学 | 8篇 |
肿瘤学 | 420篇 |
出版年
2023年 | 58篇 |
2022年 | 110篇 |
2021年 | 152篇 |
2020年 | 85篇 |
2019年 | 111篇 |
2018年 | 139篇 |
2017年 | 99篇 |
2016年 | 128篇 |
2015年 | 132篇 |
2014年 | 142篇 |
2013年 | 157篇 |
2012年 | 243篇 |
2011年 | 277篇 |
2010年 | 148篇 |
2009年 | 123篇 |
2008年 | 186篇 |
2007年 | 183篇 |
2006年 | 139篇 |
2005年 | 169篇 |
2004年 | 163篇 |
2003年 | 141篇 |
2002年 | 133篇 |
2001年 | 69篇 |
2000年 | 70篇 |
1999年 | 63篇 |
1998年 | 27篇 |
1997年 | 15篇 |
1996年 | 20篇 |
1995年 | 21篇 |
1994年 | 22篇 |
1993年 | 19篇 |
1992年 | 42篇 |
1991年 | 27篇 |
1990年 | 34篇 |
1989年 | 43篇 |
1988年 | 35篇 |
1987年 | 24篇 |
1986年 | 35篇 |
1985年 | 24篇 |
1984年 | 18篇 |
1983年 | 14篇 |
1981年 | 12篇 |
1979年 | 9篇 |
1978年 | 8篇 |
1976年 | 10篇 |
1975年 | 9篇 |
1974年 | 9篇 |
1973年 | 9篇 |
1970年 | 13篇 |
1969年 | 15篇 |
排序方式: 共有3976条查询结果,搜索用时 0 毫秒
1.
Acute Immobilization Stress and Intraventricular Injection of CRF Suppress Naloxone-Induced LH Release in Ovariectomized Estrogen-Primed Rats 总被引:1,自引:0,他引:1
Tatsuo Akema Atsuhiko Chiba Reiji Shinozaki Morihiro Oshida Fukuko Kimura & Jun-ichi Toyoda 《Journal of neuroendocrinology》1996,8(8):647-652
The present study was undertaken to evaluate the role and possible interaction of the endogenous opioid peptide (EOP) and corticotropin-releasing factor (CRF) in the acute stress-induced suppression of gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous (i.v.) injection of naloxone (10 or 20 mg/kg), an EOP antagonist, significantly elevated serum luteinizing hormone (LH) levels within 10 min in non-stressed animals. The naloxone-induced LH release was completely eliminated when tested 30 min after the onset of acute immobilization. In a subsequent study, it was found that suppression of the naloxone-induced LH release occurred as early as 5 min after the stress onset, and was still evident 60 min after the end of a 30-min period of immobilization. The effect of naloxone was restored 3 h after liberation of the animal from the 30-min immobilization. An intraventricular (i.c.v.) injection of CRF (1 or 5 μg) also significantly suppressed, in a dose-related manner, the effect of a subsequent i.v. injection of naloxone. However, an i.c.v. injection of α -helical CRF(9-41) (25 or 50 μg), a CRF antagonist, prior to immobilization, could not interfere with the suppressive effect of stress on naloxone-induced LH release. These results suggest that both acute immobilization stress and CRF can inhibit the LH secretory activity without mediation by EOP neurons. However, the stress-related suppression may involve non-CRF mechanism(s). 相似文献
2.
Distortion and movement of the expander during skin expansion. 总被引:2,自引:0,他引:2
Masamitsu Kuwahara Mitsuo Hatoko Hideyuki Tada Aya Tanaka Satoshi Yurugi Kumi Mashiba 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2003,37(1):22-27
Distortion and movement of tissue expanders can cause expansion of the wrong area, such as the naevus or the scar that is to be resected. In 71 rectangular expanders, we examined the incidence of distortion (over 15 degrees) and movement (over 3 cm). We divided the expanders into three anatomical site groups: scalp, body, and extremities, and compared the complication rate between two study groups (distortion or movement, or not). In total, the incidence of distortion was 15/71 (21%) and that of movement 5/71 (7%). Distortion occurred mainly in the extremities (11/33,33%). The implanted expanders tended to move more often in the body part (3/15, 20%). In the extremities, the bigger the angle between the axis of the implanted expander and that of the extremity, the bigger the angle of distortion. Although the incidence of complications between the two groups was not significant, except for alteration in design of the flap, we recommend that these points should be considered when preoperative plans are being made for appropriate patients. 相似文献
3.
4.
Katsuyoshi Hori Maroh Suzuki Shigeru Tanda Sachiko Saito Mika Shinozaki Qiu-Hang Zhang 《Cancer science》1991,82(11):1309-1316
To elucidate the significance of angiotensin II (AID-induced hypertension chemotherapy, changes of tissue blood flow both in normal subcutis and in tumors (AH109A, LY80) were measured with the hydrogen gas clearance method. A newly-developed anesthetic machine was used to keep the animals' condition constant. Tissue blood flow in normal subcutis and tumors always fluctuated with time under normotension. The nature and the rate of fluctuation in tumor Wood flow were almost identical in two different types of tumors. However, the fluctuation of blood flow in tumor and that in normal subcutis were almost always inversely related when blood flows in these different tissues were measured simultaneously, i.e., when tissue blood flow in normal subcutis decreased, tumor blood flow increased, and vice versa. The findings supported the idea that the connection mode between the tumor vascular bed and normal vascular bed is a parallel circuit. Vascular resistance in the normal vascular bed under All-induced hypertension seemed to be greater than that under normotension, because the All-increased tumor blood flow always exceeded the maximum tumor blood flow under normotension. Due to the fluctuations of tumor blood flow, no-flow or low-flow areas, resistant to delivery of anti-cancer drugs, moved sporadically within the tumor under the normotensive condition. However, good conditions for drug delivery to tumor tissue were induced by All-induced hypertension. 相似文献
5.
T Shinozaki 《Nippon Seikeigeka Gakkai zasshi》1987,61(11):1265-1271
Sarcoma 1509a cells (1 X 10(6] were inoculated into the right dorsum of A/Jackson mice. Laser or surgical resection was performed on the 8th or 11th day after tumor inoculation. Twenty days later, the same number of S1509a was inoculated into the contralateral side of the primary tumor. The local recurrence rate of the tumor resected by the laser was lower than that with the surgical method. Fewer mice rejected the reinoculated tumor after resection using laser method than after surgical resection. A/Jackson mice, hyperimmuned with S1509a, were inoculated with 3 X 10(6) cells of the S1509a on the 2nd, 5th, 10th and 21st days after laser irradiation. Hyperimmunized mice inoculated with the sarcoma cells on the 2nd day after laser irradiation showed higher acceptability of the tumor than immune mice without irradiation. However, other groups of mice rejected the inoculated sarcoma cells. These results suggest that suppression of tumor specific immunity was induced by laser irradiation. 相似文献
6.
K Shinozaki T Kawasaki J Kambayashi M Sakon E Shiba M Ou T Mori 《Methods and findings in experimental and clinical pharmacology》1992,14(9):663-665
Species differences in platelet aggregation induced by platelet-activating factor (PAF) were investigated by using the same procedure of platelet preparation and biological assay. Washed platelets of six different species (horses, dogs, rats, rabbits, sheep and guinea pigs) were prepared employing the same method and platelet aggregation was induced by C16-PAF. Horse platelets were most sensitive to PAF (8.0 x 10(-12) M) and rabbit platelets activated by 5.0 x 10(-11) M PAF were also sensitive enough to detect PAF in clinical samples. 相似文献
7.
Aya Umeda-Ikawa Yoshiyuki Ishii Kazuhiko Suzuki Koji Uetsuka Hjroyuki Nakayama Kunio Doi 《Experimental and toxicologic pathology》2002,54(3):239-244
Mini rats (Jcl: WistarTGN(ARGHGEN) 1Nts) (MRs) are Wistar rat (WR)-derived transgenic rats in which the expression of growth hormone (GH) gene is suppressed under the presence of antisense RNA transgene. In order to evaluate the effects of GH-deficiency on the acute injury by external stimuli, the dorsal skin responses to a single topical application with 20% hydrogen peroxide (HPO), one of the environmental oxidative stressors, were histologically compared between male MRs and WRs of 8 weeks old, whose hair cycle was under the telogen phase. As a result, formation of granulation tissues, reepithelialization and regrowth of hair follicles were delayed in MRs compared with WRs. While hair follicles of MRs of this age are under a long-lasting telogen phase after their 2nd cycle, a new hair cycle started not only in the HPO-applied area but also in the solvent-applied area with a little time lag. These findings suggest that GH-deficiency may influence the skin responses to the external chemical stimuli. 相似文献
8.
9.
N Shinozaki T Sekiya S Suzuki T Iwabuchi M Suzuki 《No shinkei geka. Neurological surgery》1992,20(3):289-293
We encountered five cases of intracranial lipoma after introduction of MRI. They were located in the quadrigeminal plate, interpeduncular fossa, pineal region and two of them were found in the cerebellopontine angle, (although intracranial lipoma in this location has been reported to be extremely rare). MRI can precisely locate a small lesion that would be overlooked by CT scans. Operative treatment was performed in two symptomatic cases (CP angle and pineal lesions) and the tumors were subtotally resected. The symptoms of the patients disappeared postoperatively. This indicated that even subtotal removal can alleviate the symptoms of intracranial lipomas and that favorable results can be obtained. 相似文献
10.
Yoshiyuki Kaneko Tomohiro Nakayama Kosuke Saito Akihiko Morita Ichiro Sato Aya Maruyama Masayoshi Soma Teruyuki Takahashi Naoyuki Sato 《Hypertension research》2006,29(9):665-671
The risk of cerebral infarction (CI) in an individual is dependent on the interplay between genetic risk factors and environmental influences. Binding of thromboxane A2 (TXA2) to its receptor (TP) modulates thrombosis/hemostasis and plays a significant role in the pathogenesis of CI. The aim of the present study was to investigate the relationship between human TP gene single nucleotide polymorphisms (SNPs) and haplotypes and CI in a Japanese population. A genetic association study was performed in 194 CI patients and 365 non-CI subjects by specifically characterizing 6 SNPs in the human TP gene (rs2271875, rs768963, rs2238634, rs11085026, rs4523 and rs4806942). Analysis demonstrated that there were significant differences in the overall distribution of genotypes and dominant or recessive models of rs2271875 and rs768963 between the CI and the non-CI groups. Multiple logistic regression analysis revealed that the C allele of rs768963 was significantly associated with CI (p = 0.029), even after adjusting for confounding factors (odds ratio: 2.41). Further, the C-T-C haplotype of rs768963-rs2238634-rs4806942 was significantly more frequent in the CI group (23.0%) than in the non-CI group (17.7%). These results suggest that specific SNPs and haplotypes may have utility as genetic markers for the risk of CI and that TP or a neighboring gene is associated with the increased susceptibility to CI. 相似文献