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Kurahara Hiroshi Mataki Yuko Idichi Tetsuya Kawasaki Yota Mori Shinichiro Sasaki Ken Arigami Takaaki Nakajo Akihiro Fukukura Yoshihiko Higashi Michiyo Ohtsuka Takao 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(7):1212-1221
International Journal of Clinical Oncology - Lymphatic metastasis is a major route of metastasis in distal cholangiocarcinoma (DCC). The present study aimed to elucidate the pattern of lymph node... 相似文献
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Sumiya Ishigami Shoji Natsugoe Akihiro Nakajo Masataka Matsumoto Yoshikazu Uenosono Takaaki Arigami Tetsuro Setoyama Hideo Arima Yasuto Uchikado Yoshiaki Kita Ken Sasaki Takashi Aikou 《Journal of gastrointestinal surgery》2008,12(8):1370-1375
Background and aim We investigated the clinical benefits of salvage gastrectomy for stage IV gastric cancer patients whose distant lesions showed
complete response after chemotherapy.
Methods We enrolled 18 stage IV gastric cancer patients whose distant metastases had disappeared or were controlled by a combination
of biweekly paclitaxel (PTX) and S-1. After chemotherapy, these patients received gastrectomy with lymph node dissection.
The postoperative outcome was analyzed with respect to both the histological effects of chemotherapy and tumor behavior.
Results Of the 18 patients, 8 had distant lymph node metastases, 9 had peritoneal dissemination, and five had multiple liver metastases
prior to chemotherapy. Fourteen patients received curative surgery (R0). No severe postoperative complications were encountered.
Pathological evaluation revealed grade 3 and grade 2 tumor regression in the primary lesion in one and five patients, respectively,
and grade 3 and grade 2 tumor regression in the lymph nodes in one and six patients, respectively. Univariate analysis of
the patients’ prognosis identified R number, gross tumor type, histological grade of tumor regression, and gender as significant
factors. Multivariate analysis showed that only the R number was an independent prognostic factor.
Conclusion R0 salvage gastrectomy following a combination of biweekly PTX and S-1 may have significant clinical efficacy for advanced
gastric cancer patients. 相似文献
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Clinical Implication of CXCL12 Expression in Gastric Cancer 总被引:1,自引:0,他引:1
Ishigami S Natsugoe S Okumura H Matsumoto M Nakajo A Uenosono Y Arigami T Uchikado Y Setoyama T Arima H Hokita S Aikou T 《Annals of surgical oncology》2007,14(11):3154-3158
PURPOSE: Recent research has revealed that tumor cells expressing chemokine receptors have a crucial impact on patient survival. However, there is no information regarding chemokine expression in gastro-intestinal cancer. This study immunohistochemically investigated CXCL12 expression in gastric cancer and evaluated its association with clinical factors, including patient prognosis. METHOD: A total of 185 gastric cancer patients receiving curative gastrectomy were assessed. CXCL12 expression was evaluated by immunohistochemical analysis. Tumors with CXCL12-positive cancer cells were regarded as CXCL12 positive, and according to the degree of CXCL12 expression, patients were divided into three groups (weak, 31 cases; moderate, 27 cases; strong, 20 cases). Correlations between CXCL12 expression and clinical factors in gastric cancer were then determined. RESULTS: CXCL12 was found in the cellular membrane of cancer cells. Seventy-four of 185 patients were classified into the CXCL12-positive group. Patients were divided into three groups according to the positivity of CXCL12 expression. Significant associations between CXCL12 and lymph node metastases (p < 0.05), depth of invasion (p < 0.01), lymphatic invasion (p < 0.01), tumor diameter (p < 0.05), and clinical stage (p < 0.01) were seen. Univariate analysis revealed that the CXCL12-positive group had significantly poorer surgical outcome than the CXCL12-negative group (p < 0.01). Multivariate analysis revealed CXCL12 to be an independent prognostic factor in gastric cancer (p = 0.02). CONCLUSION: Cancerous CXCL12 positivity was determined to be an independent prognostic factor in gastric cancer, with CXCL12-positive gastric cancer showing more-aggressive behavior. Autocrine CXCL12 secretion from tumor cells may activate CXCR-4 on the tumor cells, which may be related to of the viability of distant metastases. 相似文献
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Hiroshi Okumura Yasuto Uchikado Yoshiaki Kita Itaru Omoto Naoki Hayashi Masataka Matsumoto Ken Sasaki Tetsuro Setoyama Takaaki Arigami Yoshikazu Uenosono Daisuke Matsushita Ryosuke Desaki Masahiro Noda Naotomo Higo Keishi Okubo Masakazu Urata Yoichi Yamasaki Tetsuhiro Owaki Sumiya Ishigami Shoji Natsugoe 《Esophagus》2016,13(2):146-150
Background
Despite recent advances in treatment strategies, the management of esophageal perforation is still problematical and controversial. The purpose of the present study was to evaluate and compare the clinical data, treatment methods, and outcomes of patients with esophageal perforation according to the patients’ systemic condition (shock, systemic inflammatory response syndrome (SIRS), or non-SIRS) on arrival to the hospital.Methods
Twelve patients were treated for an esophageal perforation between 2004 and 2013. Based on the patients’ pretreatment status, the patients were divided into three groups (shock, SIRS, and non-SIRS groups), and their clinical findings, treatment methods, and outcomes were compared.Results
The numbers of patients in the shock, SIRS, and non-SIRS groups were three, three, and six, respectively. There was a difference in etiologies among the three groups as follows: two patients with spontaneous rupture were in the shock group, two patients with tumor perforation were in the SIRS group, four patients with foreign body were in the non-SIRS group, and patients with iatrogenic causes were included in all groups. The treatment procedures included conservative therapy in 4 non-SIRS patients, primary surgical repair in 4 patients (2 SIRS, 2 non-SIRS), resection in one SIRS patient, and conservative treatment with minor surgical approaches or stenting in 3 shock patients. The mortality rate was 0 %.Conclusion
Tailoring the treatment strategy to the systemic condition of patients with esophageal perforation is important. In particular, patients with shock should be treated conservatively with minor surgical approaches, including temporary stent insertion.8.
Yoichi Yamasaki Sumiya Ishigami Takaaki Arigami Yoshiaki Kita Yasuto Uchikado Hiroshi Kurahara Yuko Kijima Kosei Maemura Shoji Natsugoe 《Medical oncology (Northwood, London, England)》2018,35(3):30
As an antagonist of bone morphogenetic proteins (BMPs), 2, 4 and 7, gremlin1 plays a role in regulating organogenesis, tissue differentiation and angiogenesis. However, there is little information regarding gremlin1 in gastrointestinal cancer. We attempted to clarify how gremlin1 expression affects the clinical features and biological properties of gastric cancer. A total of 232 gastric cancer patients who received R0 gastrectomy at Kagoshima University Hospital were enrolled. Gremlin1 expression in gastric cancer was detected by immunohistochemical and western blotting methods. Correlations between clinicopathological parameters and gremlin1 expression were analyzed. Gremlin1 was identified in the cytoplasm and nucleus of all gastric cancer cell lines and some regions of surgical specimens of gastric cancer. One hundred and seventeen of the 232 patients (50.4%) were classified as gremlin1-positive based on gremlin1 expression. Gremlin1 positivity was correlated with shallower tumor depth, smaller tumor size, less nodal involvement and vessel invasion (p < 0.05). The 5-year survival rate of the gremlin1-positive group was 81%, which was significantly higher than the gremlin1-negative group (p < 0.01). Multivariate analysis revealed that gremlin1 was not selected as an independent prognostic marker. Gremlin1 expression in gastric cancer may be a useful prognostic marker that is involved with the BMP signaling pathway. Furthermore, gremlin1 may have clinical use as a diagnostic and treatment tool. 相似文献
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Shinichiro?MoriEmail author Yoshiaki?Kita Kenji?Baba Masayuki?Yanagi Kan?Tanabe Yasuto?Uchikado Hiroshi?Kurahara Takaaki?Arigami Yoshikazu?Uenosono Yuko?Mataki Hiroshi?Okumura Akihiro?Nakajo Kosei?Maemura Shoji?Natsugoe 《Surgery today》2017,47(5):643-649