全文获取类型
收费全文 | 52539篇 |
免费 | 4349篇 |
国内免费 | 148篇 |
专业分类
耳鼻咽喉 | 432篇 |
儿科学 | 2090篇 |
妇产科学 | 1602篇 |
基础医学 | 7468篇 |
口腔科学 | 1143篇 |
临床医学 | 7141篇 |
内科学 | 10222篇 |
皮肤病学 | 1001篇 |
神经病学 | 5156篇 |
特种医学 | 1224篇 |
外科学 | 4892篇 |
综合类 | 578篇 |
一般理论 | 64篇 |
预防医学 | 5981篇 |
眼科学 | 862篇 |
药学 | 3126篇 |
2篇 | |
中国医学 | 142篇 |
肿瘤学 | 3910篇 |
出版年
2024年 | 43篇 |
2023年 | 437篇 |
2022年 | 529篇 |
2021年 | 1413篇 |
2020年 | 1022篇 |
2019年 | 1534篇 |
2018年 | 1711篇 |
2017年 | 1315篇 |
2016年 | 1458篇 |
2015年 | 1585篇 |
2014年 | 1984篇 |
2013年 | 2916篇 |
2012年 | 4124篇 |
2011年 | 4200篇 |
2010年 | 2295篇 |
2009年 | 2047篇 |
2008年 | 3400篇 |
2007年 | 3449篇 |
2006年 | 3399篇 |
2005年 | 3178篇 |
2004年 | 3063篇 |
2003年 | 2793篇 |
2002年 | 2494篇 |
2001年 | 529篇 |
2000年 | 458篇 |
1999年 | 432篇 |
1998年 | 557篇 |
1997年 | 441篇 |
1996年 | 381篇 |
1995年 | 357篇 |
1994年 | 290篇 |
1993年 | 284篇 |
1992年 | 296篇 |
1991年 | 240篇 |
1990年 | 223篇 |
1989年 | 174篇 |
1988年 | 187篇 |
1987年 | 135篇 |
1986年 | 134篇 |
1985年 | 140篇 |
1984年 | 132篇 |
1983年 | 118篇 |
1982年 | 147篇 |
1981年 | 133篇 |
1980年 | 113篇 |
1979年 | 79篇 |
1978年 | 81篇 |
1977年 | 60篇 |
1976年 | 52篇 |
1971年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 531 毫秒
1.
2.
Her-Shyong Shiah Nai-Jung Chiang Chia-Chi Lin Chia-Jui Yen Hui-Jen Tsai Shang-Yin Wu Wu-Chou Su Kwang-Yu Chang Ching-Chiung Wang Jang-Yang Chang Li-Tzong Chen 《The oncologist》2021,26(4):e567-e579
Lessons Learned
- SCB01A is a novel microtubule inhibitor with vascular disrupting activity.
- This first‐in‐human study demonstrated SCB01A safety, pharmacokinetics, and preliminary antitumor activity.
- SCB01A is safe and well tolerated in patients with advanced solid malignancies with manageable neurotoxicity.
3.
4.
5.
Susan E. Hickman Alexia M. Torke Greg A. Sachs Rebecca L. Sudore Anne L. Myers Qing Tang Giorgos Bakoyannis Bernard J. Hammes 《Journal of pain and symptom management》2019,57(6):1143-1150.e5
ContextIt is especially important that patients are well informed when making high-stakes, preference-sensitive decisions like those on the Physician Orders for Life-Sustaining Treatment (POLST) form. However, there is currently no way to easily evaluate whether patients understand key concepts when making these important decisions.ObjectivesTo develop a POLST knowledge survey.MethodsExpert (n = 62) ratings of key POLST facts were used to select items for a POLST knowledge survey. The survey was administered to nursing facility residents (n = 97) and surrogate decision-makers (n = 112). A subset (n = 135) were re-administered the survey after a standardized advance care planning discussion to assess the scale's responsiveness to change.ResultsThe 19-item survey demonstrated adequate reliability (α = 0.72.). Residents' scores (x = 11.4, standard deviation 3.3) were significantly lower than surrogate scores (x = 14.7, standard deviation 2.5) (P < 0.001). Scores for both groups increased significantly after administration of a standardized advance care planning discussion (P < 0.001). Although being a surrogate, age, race, education, cognitive functioning, and health literacy were significantly associated with higher POLST Knowledge Survey scores in univariate analyses, only being a surrogate (P < 0.001) and being white (P = 0.028) remained significantly associated with higher scores in multivariate analyses.ConclusionThe 19-item POLST Knowledge Survey demonstrated adequate reliability and responsiveness to change. Findings suggest the survey could be used to identify knowledge deficits and provide targeted education to ensure adequate understanding of key clinical decisions when completing POLST. 相似文献
6.
7.
8.
9.
10.
Matrine,oxymatrine, and compound Kushen injection from the roots of Sophora flavescens: an overview of their anticancer activities
下载免费PDF全文
![点击此处可从《中国药学》网站下载免费的PDF全文](/ch/ext_images/free.gif)
In the present review, we updated current information on the chemistry, contents, and anticancer properties of matrine (MT), oxymatrine (OMT), and compound Kushen injection (CKI). The anticancer properties were focused on lung, breast, and liver cancer cells because they are most susceptible. Sources of information were from Google, Google Scholar, PubMed, PubMed Central, Science Direct, PubChem, J-Stage, Directory of Open Access Journals (DOAJ), and China National Knowledge Infrastructure (CNKI). Reference was also made on botanical websites, such as Flora of China and World Flora Online. MT and OMT are dominant quinolizidine alkaloids from the roots of Sophora flavescens (Kushen) of the family Fabaceae. Against lung, breast, and liver cancer cells, MT and OMT inhibit cell proliferation; induce cell cycle arrest, apoptosis, and autophagy; restrict angiogenesis; and inhibit cell metastasis, invasion, and migration. The processes involve various molecular targets and signaling pathways. CKI is a traditional Chinese medicine (TCM) composed of root extracts of S. flavescens and Smilax glabra (Baituling) of the family Smilacaceae. With MT and OMT as major components, CKI has been approved for the treatment of cancer in China more than 20 years ago. In recent years, systematic reviews and meta-analysis have been undertaken to evaluate the anticancer effects of CKI. When CKI is used alone and in combination with chemotherapy of western medicine, there is much to be learned concerning their interactions besides their individual and integrated efficacy. Some perspectives of MT, OMT, and CKI are discussed, and their suggestions for future research are provided. 相似文献