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排序方式: 共有500条查询结果,搜索用时 15 毫秒
1.
Amelie Perron RN PhD Trudy Rudge RN RMHN PhD Dave Holmes RN PhD 《Nursing philosophy》2010,11(2):100-111
The concept of citizenship is becoming more and more prominent in specific fields, such as psychiatry/mental health, where it is constituted as a solution to the issues of exclusion, discrimination, and poverty often endured by the mentally ill. We argue that such discourse of citizenship represents a break in the history of psychiatry and constitutes a powerful strategy to counter the effects of equally powerful psychiatric labelling. However, we call into question the emancipatory promise of a citizenship agenda. Foucault's concept of governmentality is helpful in understanding the production of the citizen subject, its location within the ‘art of government’, as well as the ethical and political implications of citizenship in the context of mental health. 相似文献
2.
Enhancement of motility by treating spermatozoa with an antioxidant solution (Sperm-Fit) following ejaculation 总被引:1,自引:1,他引:1
Parinaud J; Le Lannou D; Vieitez G; Griveau JF; Milhet P; Richoilley G 《Human reproduction (Oxford, England)》1997,12(11):2434-2436
Oxygen radical generation is known to be detrimental to sperm function,
especially motility, through the lipid peroxidation of the membranes.
Generation of reactive oxygen species can be induced by leukocyte
contamination, sperm centrifugation and the presence of abnormal
spermatozoa with excess residual cytoplasm. This study aims to evaluate the
effect on sperm motility of incubation in an antioxidant-containing
solution, during liquefaction and centrifugation. Thirty semen samples were
each divided into two equal parts: one mixed with Tyrode's solution, the
other with a salt solution containing antioxidants (Sperm- Fit; Ellios
Bio-Media, Paris, France). All the procedures were identical in the two
groups. The ratio of leukocytes to spermatozoa was significantly correlated
with the motility after liquefaction and after a 24 h incubation in routine
in-vitro fertilization (IVF) medium and with the number of motile
spermatozoa recovered after Percoll preparation. Moreover, when this ratio
was > or = 0.2, all motility parameters were lowered. Incubation with
Sperm-Fit allowed a higher percentage of motility after Percoll preparation
when the ratio was > or = 0.2 (48 +/- 5% versus 41 +/- 6% for Sperm-Fit
and Tyrode's solution respectively; P < 0.05) and a greater number of
motile spermatozoa recovered after Percoll preparation, whatever the ratio
(3.2 +/- 1.0 x 10(6) versus 2.4 +/- 0.7 x 10(6) for Sperm-Fit and Tyrode's
solution respectively when ratio > or = 0.2; 18.1 +/- 3.4 x 10(6) versus
14.4 +/- 2.9 x 10(6) for Sperm-Fit and Tyrode's solution respectively when
ratio < 0.2; P < 0.05). These results show that incubation with
antioxidants during liquefaction and centrifugation increases recovery of
motile spermatozoa.
相似文献
3.
Gemins modulate the expression and activity of the SMN complex 总被引:1,自引:0,他引:1
Feng W Gubitz AK Wan L Battle DJ Dostie J Golembe TJ Dreyfuss G 《Human molecular genetics》2005,14(12):1605-1611
Reduction in the expression of the survival of motor neurons (SMN) protein results in spinal muscular atrophy (SMA), a common motor neuron degenerative disease. SMN is part of a large macromolecular complex (the SMN complex) that includes at least six additional proteins called Gemins (Gemin2-7). The SMN complex is expressed in all cells and is present throughout the cytoplasm and in the nucleus where it is concentrated in Gems. The SMN complex plays an essential role in the production of spliceosomal small nuclear ribonucleoproteins (snRNPs) and likely other RNPs. To study the roles of the individual proteins, we systematically reduced the expression of SMN and each of the Gemins (2-6) by RNA interference. We show that the reduction of SMN leads to a decrease in snRNP assembly, the disappearance of Gems, and to a drastic reduction in the amounts of several Gemins. Moreover, reduction of Gemin2 or Gemin6 strongly decreases the activity of the SMN complex. These findings demonstrate that other components of the SMN complex, in addition to SMN, are critical for the activity of the complex and suggest that Gemin2 and Gemin6 are potentially important modifiers of SMA as well as potential disease genes for non-SMN motor neuron diseases. 相似文献
4.
Juliana F. W. Cohen Amelie A. Hecht Gabriella M. McLoughlin Lindsey Turner Marlene B. Schwartz 《Nutrients》2021,13(3)
The school environment plays an important role in children’s diets and overall health, and policies for universal free school meals have the potential to contribute to positive child health outcomes. This systematic review evaluates studies examining the association between universal free school meals and students’ school meal participation rates, diets, attendance, academic performance, and Body Mass Index (BMI), as well as school finances. The search was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). A search for studies published in economically developed countries published through December 2020 was performed in PubMed, Education Resources Information Center (ERIC), Thomson Reuters’ Web of Science, and Academic Search Ultimate, followed by examining the references in the resultant literature. A total of 47 studies were identified and the Newcastle-Ottawa Scale (NOS) was applied to assess bias. Nearly all studies examining universal free school meals found positive associations with school meal participation. Most studies examining universal free school meals that included free lunch found positive associations with diet quality, food security, and academic performance; however, the findings of studies examining only universal free breakfast were mixed. Research findings were similarly mixed when examining attendance as an outcome. Concerns about adverse outcomes on student BMI were not supported by the literature; in fact, several studies detected a potentially protective effect of universal free school meals on BMI. Research examining the impact of universal free meals on school finances was limited, but suggest that lower-income school districts in the U.S. may have positive financial outcomes from participation in universal free school meal provisions. Additionally, providing free meals to students may be associated with improved household incomes, particularly among lower-income families with children. Further research is needed to examine the financial implications of universal free meals for both school districts and families. Overall, universal free school meals may have multiple benefits for students and countries should consider universal free school meal provisions with strong nutrition guidelines. (PROSPERO registration: CRD42020221782). 相似文献
5.
Fabio Efficace Gary S. Collins Francesco Cottone Johannes M. Giesinger Kathrin Sommer Amelie Anota Michael Maia Schlussel Paola Fazi Marco Vignetti 《Value in health》2021,24(2):250-267
ObjectivesAssessment of patient-reported outcomes (PROs) in oncology is of critical importance because it provides unique information that may also predict clinical outcomes.MethodsWe conducted a systematic review of prognostic factor studies to examine the prognostic value of PROs for survival in cancer. A systematic literature search was performed in PubMed for studies published between 2013 and 2018. We considered any study, regardless of the research design, that included at least 1 PRO domain in the final multivariable prognostic model. The protocol (EPIPHANY) was published and registered in the International Prospective Register of Systematic Reviews (CRD42018099160).ResultsEligibility criteria selected 138 studies including 158 127 patients, of which 43 studies were randomized, controlled trials. Overall, 120 (87%) studies reported at least 1 PRO to be statistically significantly prognostic for overall survival. Lung (n = 41, 29.7%) and genitourinary (n = 27, 19.6%) cancers were most commonly investigated. The prognostic value of PROs was investigated in secondary data analyses in 101 (73.2%) studies. The EORTC QLQ-C30 questionnaire was the most frequently used measure, and its physical functioning scale (range 0-100) the most frequent independent prognostic PRO, with a pooled hazard ratio estimate of 0.88 per 10-point increase (95% CI 0.84-0.92).ConclusionsThere is convincing evidence that PROs provide independent prognostic information for overall survival across cancer populations and disease stages. Further research is needed to translate current evidence-based data into prognostic tools to aid in clinical decision making. 相似文献
6.
Chanita Hughes Susan K Peterson Amelie Ramirez Kipling J Gallion Paige Green McDonald Celette Sugg Skinner Deborah Bowen 《Cancer epidemiology, biomarkers & prevention》2004,13(7):1146-1155
Although recruitment of ethnic and racial minorities in medical research has been evaluated in several studies, much less is known about the methods used to recruit these populations to participate in cancer genetics research. This report reviews the resources that have been used to identify and recruit ethnic and racial minorities to participate in hereditary breast cancer research. Overall, hospital-based resources were used most often to identify potential subjects, and active recruitment methods were used most frequently to enroll eligible subjects. This review suggests that there appears to be a finite number of resources and strategies to identify and recruit potential subjects to participate in cancer genetics research; however, options for improving awareness about cancer genetics research among ethnic and racial minorities have not been extensively evaluated. To study ethnic and racial minority participation in cancer genetics research, stronger evaluation components will need to be integrated into research methods. Both observational and experimental studies are needed to determine resources that are most effective for identifying potential subjects who are ethnic and racial minorities and to evaluate the effects of different recruitment strategies on enrollment decisions among these populations. 相似文献
7.
Gardner Cameron L. Pavel-Dinu Mara Dobbs Kerry Bosticardo Marita Reardon Paul K. Lack Justin DeRavin Suk See Le Kent Bello Ezekiel Pala Francesca Delmonte Ottavia M. Malech Harry Montel-Hagen Amelie Crooks Gay Acuto Oreste Porteus Matthew H. Notarangelo Luigi D. 《Journal of clinical immunology》2021,41(5):863-863
Journal of Clinical Immunology - A Correction to this paper has been published: https://doi.org/10.1007/s10875-021-01030-6 相似文献
8.
Arne Böttcher Thomas Mencke Amelie Zitzmann Rainald Knecht Nathan Jowett Gabriele Nöldge-Schomburg Hans Wilhelm Pau Steffen Dommerich 《European archives of oto-rhino-laryngology》2014,271(2):345-352
Endotracheal intubation has been associated with a threefold higher incidence of laryngopharyngeal complaints following anesthesia in comparison to laryngeal mask airway. Such complaints, including hoarseness and sore throat, have been reported in up to 90 % of patients within 24 h of extubation. The purpose of this study was to determine which preoperatively documented clinical and anatomic parameters are predictive of laryngo-pharyngeal trauma resulting from elective endotracheal intubation. Fifty-three patients undergoing ENT procedures requiring general anesthesia with endotracheal intubation were recruited. Pre and postoperative laryngostroboscopic examination was performed and findings correlated to preoperative clinical and anatomic parameters. Readily assessed anatomic parameters including height (>180 cm) and weight (>80 kg) correlated significantly to the Eckerbom grade of intubation-associated acute laryngeal injury (rs = 0.374; p = 0.006 and rs = 0.278; p = 0.044, respectively). The mandibular protrusion test also correlated significantly to the Eckerbom grade (rs = 0.462, p = 0.001) while the upper-lip-bite test showed significant correlation to impaired vocal fold oscillation (rs = 0.288, p = 0.036), with injury prediction sensitivities of 37.5 and 39.4 %, respectively. No parameters correlated to subjective complaints (n = 5, 9.2 %). This study provides suggestions on how to improve the classification of intubation-associated laryngeal injuries as well as providing the basis for larger clinical trials in other surgical subspecialties. 相似文献
9.
Therrien Amelie Silvester Jocelyn A. Leonard Maureen M. Leffler Daniel A. Fasano Alessio Kelly Ciaran P. 《Digestive diseases and sciences》2021,66(6):1989-1997
Digestive Diseases and Sciences - Non-responsive celiac disease (NRCD) has many aetiologies, including gluten exposure. Budesonide may be used for refractory celiac disease (RCD) and celiac crisis.... 相似文献
10.
Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association
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Alina C. Hilger Jan Halbritter Tracie Pennimpede Amelie van der Ven Georgia Sarma Daniela A. Braun Jonathan D. Porath Stefan Kohl Daw‐Yang Hwang Gabriel C. Dworschak Bernhard G. Hermann Anna Pavlova Osman El‐Maarri Markus M. Nöthen Michael Ludwig Heiko Reutter Friedhelm Hildebrandt 《Human mutation》2015,36(12):1150-1154
The VATER/VACTERL association describes the combination of congenital anomalies including vertebral defects, anorectal malformations, cardiac defects, tracheoesophageal fistula with or without esophageal atresia, renal malformations, and limb defects. As mutations in ciliary genes were observed in diseases related to VATER/VACTERL, we performed targeted resequencing of 25 ciliary candidate genes as well as disease‐associated genes (FOXF1, HOXD13, PTEN, ZIC3) in 123 patients with VATER/VACTERL or VATER/VACTERL‐like phenotype. We detected no biallelic mutation in any of the 25 ciliary candidate genes; however, identified an identical, probably disease‐causing ZIC3 missense mutation (p.Gly17Cys) in four patients and a FOXF1 de novo mutation (p.Gly220Cys) in a further patient. In situ hybridization analyses in mouse embryos between E9.5 and E14.5 revealed Zic3 expression in limb and prevertebral structures, and Foxf1 expression in esophageal, tracheal, vertebral, anal, and genital tubercle tissues, hence VATER/VACTERL organ systems. These data provide strong evidence that mutations in ZIC3 or FOXF1 contribute to VATER/VACTERL. 相似文献