全文获取类型
收费全文 | 428篇 |
免费 | 19篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 9篇 |
妇产科学 | 5篇 |
基础医学 | 52篇 |
口腔科学 | 2篇 |
临床医学 | 37篇 |
内科学 | 66篇 |
皮肤病学 | 11篇 |
神经病学 | 58篇 |
特种医学 | 23篇 |
外科学 | 62篇 |
综合类 | 1篇 |
一般理论 | 1篇 |
预防医学 | 48篇 |
眼科学 | 2篇 |
药学 | 38篇 |
肿瘤学 | 22篇 |
出版年
2022年 | 2篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 3篇 |
2016年 | 12篇 |
2015年 | 12篇 |
2014年 | 5篇 |
2013年 | 24篇 |
2012年 | 17篇 |
2011年 | 11篇 |
2010年 | 10篇 |
2009年 | 17篇 |
2008年 | 20篇 |
2007年 | 32篇 |
2006年 | 27篇 |
2005年 | 26篇 |
2004年 | 22篇 |
2003年 | 25篇 |
2002年 | 20篇 |
2001年 | 7篇 |
2000年 | 11篇 |
1999年 | 6篇 |
1998年 | 9篇 |
1997年 | 10篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 8篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1972年 | 2篇 |
1969年 | 3篇 |
1964年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有447条查询结果,搜索用时 15 毫秒
1.
2.
Regan E. Giesinger Adrianne R. Bischoff Patrick J. McNamara 《Congenital heart disease》2019,14(2):311-316
Ligation of a hemodynamically significant ductus arteriosus results in significant changes in loading conditions which have predictable consequences. Postligation cardiac syndrome, defined as hypotension requiring inotropic support and failure of oxygenation and ventilation, may occur 6‐12 hours following ligation due to left ventricular systolic and diastolic failure, respectively. Afterload is the primary driver of this decompensation. In this review, we describe the pathophysiological changes in loading conditions associated with postligation cardiac syndrome and other contributors to cardiovascular dysfunction following ductal ligation. We present strategies for perioperative optimization and a physiology‐based algorithm for postoperative management guided by targeted neonatal echocardiography. The use of these strategies to reduce the frequency of postligation deterioration may be an avenue to improve outcomes for neonates in this vulnerable patient population. 相似文献
3.
Jacobo E. Mintzer M.D. Mark P. Rubert Ph.D. David Loewenstein Ph.D. Edgardo Gamez M.D. Agustin Millor L.C.S.W. Rocio Quinteros M.S. Linda Flores M.D. Meridith Miller R.N. Ph.D. Adrianne Rainerman Carl Eisdorfer Ph.D. M.D. 《Community mental health journal》1992,28(4):293-303
This study assessed Cuban-American Hispanic and White non-Hispanic daughters who were major caregivers for their mothers suffering from Alzheimer's Disease. Although patients in both ethnic groups did not differ in their level of cognitive and functional impairment, Cuban-American Hispanic patients were significantly more likely to be living in their daughters' homes while the White non-Hispanic patients resided in institutional settings. Caregivers were equivalent in their knowledge and utilization of community services, but Cuban-American daughters were significantly more aware of financial aid resources. Cuban-American patients were significantly more depressed than their White non-Hispanic counterparts with daughters showing similar but nonsignificant trends. The impact of cultural factors on caregiving is discussed. 相似文献
4.
The advantages of multicenter trials are numerous: quicker recruitment of the necessary number of patients, clearer results which are more convincing and whose acceptance is higher, as the patient sample of multicenter trials is supposed to be representative. However, multicenter trials require strong efforts for quality assurance concerning admission, treatment and follow-up, thus a highly developed coordinating center is needed. Data on recruitment and protocol compliance, i.e. deviations from the study protocol, are presented for the study of the treatment of metastatic renal cell carcinoma and discussed with respect to their impact on the results of the study. 102 patients were randomized either for IFN alpha-2C or IFN alpha-2C plus medroxyprogesteroneacetate. 16% of the patients violated inclusion criteria and essential data were missing in 16% of the patients. Overall treatment results (remission rate of 5.6%, median survival time of 7 months) and the data on adverse events have been biased by lack of protocol compliance. However, the results concerning the lack of differences between treatments remain valid. 相似文献
5.
Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states 总被引:3,自引:0,他引:3
This study aimed to determine whether changes in plasma heparin-releasable lipoprotein lipase (LPL) activity following a brisk
walk were associated with decreases in fasting and/or postprandial triglyceride (TG) concentrations. Two groups of pre-menopausal
women participated. In one group (fasting study group, n=10), TG concentrations and post-heparin plasma LPL activity were measured in the fasted state on two occasions: ~18 h after
a 2-h treadmill walk at 50% maximal oxygen uptake (exercise trial); and after a day of no exercise (control trial). The other
group (postprandial study group, n=9) undertook two oral fat tolerance tests (blood samples taken fasting and for 6 h after a high-fat meal), with plasma LPL
activity measured 6 h after meal ingestion. Pre-conditions were the same as for the fasting study group (i.e. control and
prior exercise). Prior exercise reduced fasting TG concentrations by 23 (7)% (fasting study group) [mean (SEM)] and by 18
(9)% (postprandial study group) (both P<0.05), and the postprandial TG response by 23 (6)% (postprandial study group) (P<0.01). Plasma LPL activity was not significantly increased by exercise in either the fasting or postprandial study groups.
However, exercise-induced changes in both fasting and postprandial LPL activity were significantly correlated with the respective
exercise-induced changes in fasting TG concentration and the postprandial TG response (r=−0.70 and −0.77 respectively, P<0.05 for both). These data suggest that increased LPL activity may contribute to the hypotriglyceridaemic effect of moderate
exercise, although other mechanisms are also likely to be involved.
Electronic Publication 相似文献
6.
Shannon Mendez Jamie Kubota Adrianne M. Widaman John Gieng 《Journal of nutrition education and behavior》2021,53(7):608-613
ObjectiveTo evaluate the effects of a group-based Advance Quantity Meal Preparation (AQMP) program on the consumption of home-cooked meals, cooking attitudes, and self-efficacy in healthy adults.MethodsParticipants (n = 10) in a group setting prepared healthy meals weekly consisting of 10 entrees and 5 snacks for 6 weeks. A survey assessing cooking attitudes, cooking self-efficacy, and cooking behavior and consumption at 3 time points: preprogram, postprogram (T2), and 3 months postprogram (T3).ResultsThe AQMP program increased the proportion of overall home-cooked meal consumption (T2, P = 0.03), home-cooked dinner consumption (T2, P = 0.04), cooking attitudes (T3, P = 0.01), and cooking self-efficacy (T2, P = 0.002).Conclusions and ImplicationsThis pilot study indicates that AQMP may increase home-cooked meal consumption, cooking attitudes, and cooking self-efficacy. 相似文献
7.
P. E. Grebow J. A. Treitman E. P. Barry D. J. Blasucci S. T. Portelli N. C. Tantillo R. A. Vukovich E. S. Neiss 《European journal of clinical pharmacology》1982,22(4):295-299
Summary Two formulations of indapamide tablets (2.5 mg) were given as a 5.0 mg dose and the subsequent blood levels were compared to those obtained after administration of a 5.0 mg solution. The study was conducted as a randomized three-way crossover design using healthy male volunteers. The drug was well tolerated by all the subjects involved. The area under the blood concentration versus time curve, extrapolated to infinity was essentially the same for all three formulations (4.2, 4.7, and 4.4 µg-h/ml). Statistical comparison of the blood levels from the two tablets showed that one tablet had a significantly greater maximum blood concentration (263 vs 231 ng/ml) and a significantly shorter time of maximum blood concentration (2.3 vs 3.5 h). Cmax (333 ng/ml) and tmax (0.7 h) values for the solution were significantly higher than either tablet. The average half-life (-phase) for all three formulations was 15 h, while the average systemic clearance was 20 ml/min. Indapamide has a low clearance rate and there was no evidence that the drug undergoes a first-pass effect. 相似文献
8.
9.
10.
Feldstein AC Nichols GA Smith DH Rosales AG Perrin N 《Journal of general internal medicine》2008,23(9):1339-1345
BACKGROUND Limited community-based data describe weight change after diabetes diagnosis.
OBJECTIVE To evaluate weight change patterns and associations in the 1st year after diabetes mellitus type 2 diagnosis.
DESIGN Retrospective cohort study.
PARTICIPANTS Patients aged 21–75 with diabetes mellitus type 2 diagnosed between 1 January 1997 and 31 December 2004, identified from electronic
medical records in Kaiser Permanente Northwest, a health maintenance organization. Eligible patients met weight measurement
criteria (a baseline and three additional weight measurements) and did not have a condition associated with unintentional
weight change (n = 4,135).
MEASUREMENTS We estimated 12-month patient weight trajectories using growth curve analyses, grouped similar trajectories using cluster
analysis, and compared characteristics among groups.
RESULTS The four weight trajectory groups were “higher stable weight” (n = 757; 18.3%), “lower stable weight” (n = 2,236; 54.1%),
“weight gain” (n = 664; 16.0%), and “weight loss” (n = 478; 11.6%). After adjustments, members of the weight-loss group were
more likely than those in the weight-gain group to be older, female, take fewer medications, have had nutritionist visits,
and have a lower mean HbA1c. Those in the weight-loss group were less likely to be in a race group at higher risk for obesity, have depression or dyslipidemia,
or have taken >30 days of a sulfonylurea alone or with metformin.
CONCLUSIONS A small-but-substantial group of patients had a mean weight trajectory that included a clinically significant weight loss.
Weight-loss trajectories were strongly associated with better glycemic control when compared to weight gain. Patients with
certain characteristics may need more support for weight loss.
This study was supported by grant no. R21 DK073546–02 (Weight in Secondary Prevention) from the National Institute of Diabetes
and Digestive and Kidney Diseases 相似文献