全文获取类型
收费全文 | 2644篇 |
免费 | 136篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 148篇 |
妇产科学 | 60篇 |
基础医学 | 290篇 |
口腔科学 | 71篇 |
临床医学 | 189篇 |
内科学 | 662篇 |
皮肤病学 | 70篇 |
神经病学 | 134篇 |
特种医学 | 49篇 |
外科学 | 450篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 184篇 |
眼科学 | 53篇 |
药学 | 181篇 |
中国医学 | 15篇 |
肿瘤学 | 166篇 |
出版年
2023年 | 21篇 |
2022年 | 30篇 |
2021年 | 69篇 |
2020年 | 39篇 |
2019年 | 67篇 |
2018年 | 95篇 |
2017年 | 50篇 |
2016年 | 48篇 |
2015年 | 57篇 |
2014年 | 68篇 |
2013年 | 98篇 |
2012年 | 191篇 |
2011年 | 207篇 |
2010年 | 80篇 |
2009年 | 66篇 |
2008年 | 162篇 |
2007年 | 170篇 |
2006年 | 162篇 |
2005年 | 180篇 |
2004年 | 164篇 |
2003年 | 152篇 |
2002年 | 139篇 |
2001年 | 71篇 |
2000年 | 89篇 |
1999年 | 53篇 |
1998年 | 12篇 |
1997年 | 10篇 |
1996年 | 7篇 |
1995年 | 12篇 |
1994年 | 9篇 |
1993年 | 9篇 |
1992年 | 20篇 |
1991年 | 25篇 |
1990年 | 13篇 |
1989年 | 16篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1984年 | 9篇 |
1983年 | 7篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 9篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 4篇 |
排序方式: 共有2787条查询结果,搜索用时 15 毫秒
1.
2.
Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze. 总被引:2,自引:0,他引:2
Fernando Ca?adas Diana Cardona Eva Dávila Fernando Sánchez-Santed 《Toxicological sciences》2005,85(2):944-951
Organophosphate compounds are cholinesterase inhibitors widely used in agriculture, industry, household products, and even as chemical weapons. Their major mechanism of acute toxic action is the inhibition of acetylcholinesterase, which is responsible for the degradation of the neurotransmitter acetylcholine. An organophosphorus ester-induced chronic neurotoxicity (OPICN) syndrome has been proposed. The OPICN syndrome could result from both long-term exposure to subclinical doses of OPs and after acute poisoning. Development of animal models for the cognitive decline are required and could later help to elucidate the mechanisms involved in this long-term effect on the central nervous system. Previously, we have found performance decrements in a four-trial repeated acquisition spatial task in a water maze. The present study includes two experiments to extend the long-term behavioral effects observed. Rats were injected either once or twice with chlorpyrifos (CPF) and then tested months after in a two-trial repeated acquisition task in a water maze. Our results confirm and extend the long-term behavioral effects of subcutaneous administration of CPF. The two treatments used produced performance decrements that suggest functional central nervous system alterations. 相似文献
3.
4.
5.
Hybrid tumours of the salivary glands. A report of two cases involving the palate and a review of the literature 总被引:1,自引:0,他引:1
Luz María Ruíz-Godoy R Adalberto Mosqueda-Taylor Lourdes Suárez-Roa Adela Poitevin Esther Bandala-Sánchez Abelardo Meneses-García 《European archives of oto-rhino-laryngology》2003,260(6):312-315
Hybrid tumours are very rare salivary gland lesions composed of two or more different tumoural entities in a single neoplasm that arise within a definite topographical region. In most cases adenoid cystic carcinoma has been the predominant component in these lesions. In this study we describe two patients with hybrid tumours located in the palate, one in a 49-year-old woman and one in a 71-year-old man. The first case involved adenoid cystic carcinoma and mucoepidermoid carcinoma, and the patient in the second case exhibited adenoid cystic carcinoma and epithelial-myoepithelial carcinoma. Both patients were treated with surgery and radiotherapy, and there has been no evidence of recurrence after 13 and 36 months of follow-up, respectively. The recognition of the histologic component with the higher grade of malignancy in every case of hybrid tumour of the salivary glands is a necessary step to determine the biological behaviour and, consequently, to determine the proper therapeutic approach. 相似文献
6.
J A Represa J A De Diego L M Molina I Delgado M G Calvo J F Ca?izo A Menchero M Gea 《The Journal of cardiovascular surgery》1986,27(4):426-430
Three cases of popliteal artery entrapment syndrome, one of them bilateral, are presented with a review of the literature, with special reference to the embryological development of the popliteal space and the diagnostic and therapeutic problems presented by this syndrome. 相似文献
7.
M E Senocak G Kale N Büyükpamuk?u A Hi?s?nmez M Ca?lar 《Journal of pediatric surgery》1990,25(6):681-684
Gastric teratoma is a very rare benign tumor. Fifty-three cases, only two of which were females, have previously been reported. This report concerns two cases of teratoma arising from stomach. One of them is the third female case described in the literature. 相似文献
8.
A Cabrera M Sánchez M A Izquierdo E Pastor J M Galdeano S Mintegui M A Lizarraga A Cuadrado M Ca?ada 《Revista espa?ola de cardiología》1992,45(10):637-644
Between 1985-1990 we studied by means of two-dimensional echocardiography 286 patients with isolated ventricular septal defect (VSD). A hundred and sixty three being male and 123 female, as a mean age of 5 +/- 3 months. Sixty two cases (22.3%) reveales associated anomalies and in other 63 (22.4%) there was in the evolution an aneurysm of the septum membranous. The projections used were apical 4-chamber, with or without aortic root; parasternal long-short axis of great arterias or at ventricular level; subcostal 4-chamber; right oblique outlet right outflow tract and left oblique outlet left and right outflow tracts. Patients with VSD smaller than 3 mm were excluded. Perimembranous defects, 189 cases (66%), were more frequent than muscular, 91 31.8%), and subarterial defects, 6 (2.1%). Only 19 (9 apical muscular, 6 perimembranous outlet and 4 perimembranous trabecular) were initially misclassified. The diameter of the VSD was large in subarterial (0.85 +/- 0.1 cm) and perimembranous outlet VSD (0.75 +/- 0.5 cm) compared with the rest. Each group of defects was more easily shown by one particular projection except trabecular muscular defect. In conclusion, we are able to state that two-dimensional echocardiography enables us to discover the size and situation of isolated ventricular defects. 相似文献
9.
P. A. Gómez R. D. Lobato J. J. Rivas A. Cabrera R. Sarabia S. Castro M. Castañeda J. M. Cañizal 《Acta neurochirurgica》1989,101(1-2):35-41
Summary The authors review the literature on subarachnoid haemorrhage of unknown aetiology (SAHUE) and analyze a personal series of 212 patients diagnosed as SAHUE. These patients represent 30% of all cases of primary SAH admitted over a 14.5 year period.The age, sex, antecedents and initial clinical presentation of patients with SAHUE were indistinguishable from those of patients with subarachnoid haemorrhage due to ruptured aneurysm (SAHRA). However, the present series of SAHUE compare favourably with both a personal and a previously reported series of SAHRA insofar as clinical grade on admission (94% of patients in grades I–II of Botterell), presence of blood on CT (51%), vasospasm (5%), ischaemic deficits (3.3%), persistent hydrocephalus (3.5%), rebleeding (6%) and fatal result (3.9%) are concerned.The amount of blood on CT scan in our patients with SAHUE was associated with a significantly higher incidence of brain ischaemia and hydrocephalus but did not correlate with the Botterell grade on admission or final outcome, which were good in the majority of cases regardless of the presence or not of visible cisternal haemorrhage. The results of the present series confirm that the final prognosis of patients with primary SAH showing normal four-vessel cerebral angiography is essentially favourable. 相似文献
10.
García Del Caño G Gerrikagoitia I Sarasa M Matute C Martínez-Millán L 《Journal of neurocytology》2000,29(7):509-523
Unilateral hypoglossal nerve axotomy was used as a model to analyse immunohistochemically the expression of the GluR1, GluR2, GluR3, and GluR4 glutamate receptor subunits of the -amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype and the NR1 subunit of the N-methyl-D-aspartate (NMDA) subtype in the different morphofunctional hypoglossal pools from 1 to 45 days postaxotomy. Following hypoglossal nerve axotomy, the percentage of motoneurons that were GluR1-immunopositive and the labeling intensity for this subunit was increased in some hypoglossal pools. Immunolabeling for the GluR2 subunit was undetectable. These results contrast with the unchanged pattern for these two subunits after sciatic nerve axotomy previously described. Image analysis showed a significant decrease in the intensity of immunohistochemical labeling for the GluR2/3 and GluR4 subunits in motoneurons, although most motoneurons were still immunopositive for these 2 subunits after axotomy. The intensity of immunolabeling for the NR1 subunit was slightly decreased postlesion, whereas the percentage of NR1-immunopositive motoneurons increased. Immunoreactivity returned to basal levels 45 days postlesion. These findings show that in axotomized hypoglossal motoneurons, i) AMPA and NMDA receptor subunits are still expressed, ii) the composition of the ionotropic glutamate receptor subunit pool is subjected to continuous changes during the regeneration process, iii) AMPA receptors, if functional, would have physiological properties different to those in intact motoneurons, and iv) the various AMPA receptor subunits are differentially regulated. The present results also suggest a faster recovery of basal levels of immunoreactivity for caudally localised groups of motoneurons which could reflect a caudo-rostral sequential functional revovery in the hypoglossal nucleus. 相似文献