肝切除、肝门-空肠吻合治疗Bismuth Ⅳ肝门部胆管癌

目的 探讨肝切除、肝门-空肠吻合治疗Bismuth Ⅳ型肝门部胆管癌.方法 9例Bismuth Ⅳ型肝门部胆管癌均行肝切除(Ⅳb段、Ⅴ段及尾状叶部分肝组织切除),胆道的重建采用肝门-空肠吻合,所有胆管分支均不结扎,均汇人肝门胆汁湖.结果 9例患者均行肝切除、达到Rο根治性切除、肝门-空肠吻合.围手术期无死亡,术后四周血清AST、ALT、TB明显下降.术后出现胆漏1例、胆道少量出血1例、伤口感染1例,4例均经保守治疗后顺利出院.Karnofsky评分平均为86分.平均随访24.9(9～42)个月,1例于术后9个月死于肿瘤肝内转移,1例于术后17个月死于肿瘤腹腔广泛转移,其余7例目前健康生存,术后已平均生存28.3个月.结论 肝切除、肝门-空肠吻合可提高肝门部胆管癌手术根治切除率、利于胆道通畅引流,延长患者生存时间.     

食管贲门癌切除术后胸胃穿孔三例诊治体会

目的 探讨食管贲门癌切除术后胸胃穿孔的诊断，发生原因及防治措施。方法 收治食管贲门癌216例，全部行癌肿切除。胃食管吻合术。结果 术后发生胸胃穿孔3例。2例治愈。1例好转。结论 病人的应激性反应和手术操作的技巧因素是导致本并发症的主要原因。治疗方法采取先予胸腔闭式引流，胃肠减压，空肠造瘘，抗感染及加强营养支持等保守治疗，必要时行二次开胸穿孔修补术。     

甲状腺孤立性纤维性肿瘤1例

甲状腺孤立性纤维性肿瘤（solitary fibrous tumor,SFT）极为罕见,至今国外文献报道仅19例,国内尚未见系统报道,现将我院收治的1例报道如下。1病例资料女性,78岁,以“右颈部肿块5月”入院。既往有冠心病史2年,安装心脏起搏器1年余。体格检查：气管偏左,右侧颈部可触及一肿物,类圆形,大小约5cm×3cm×3cm,质韧,表面尚光滑,边界不清,不易活动,无压痛,随吞咽上下活动,     

EVLT治疗下肢静脉曲张52例报告

2005年10月～2006年12月,我们采用腔内激光闭合术(EVLT)治疗下肢静脉曲张患者52例,疗效满意.现报告如下.     

胆内瘘18例诊治分析

胆内瘘是胆石症发展过程中少见的并发症,多见于老年患者。1980年5月～1998年2月,我们共收治18例,获得满意疗效。现报告如下。临床资料:本组男8例,女10例,年龄42～76岁,平均年龄62.5岁;胆石症病史10年以上7例,5～10年8例,5年以下3例。18例均有不同程度的右上腹痛,反复发热13例,黄疸5例,顽固性腹泻4例,术中(或术前钡餐、钡灌肠)见瘘口情况如表1。表1　18例胆内瘘情况十二指肠肝总管横结肠胃窦胆囊颈(管)胆囊体胆囊底胆总管合计1361022224112　　手术方法:在全麻或硬膜外麻醉下行胆囊切除术。其中2例为Mirizzi综合征患者,1例行胆囊大部切除后…     

CD40在肝硬化门静脉高压症脾脏中的表达与临床意义

Objective To investigate the expression and clinical significance of CD40 in the spleen of cirrhotic portal hypertension. Methods Expression of CD40 was determined with S-P immunohistochemistry in spleen specimens from 50 cases of cirrhotic portal hypertension and 15 healthy individuals. Results The CD40 positive rates in normal spleen and cirrhotic spleen were 86.7% and 36.0%, respectively. There was a significant difference between the 2 groups (P＜0.05). There was a negative correlation between the expression of CD40 and Child grades of liver function and cirrhotic splenic types(P＜0. 05). Conclusion CD40 might reflect the changes of splenic immune function,which might be one of more exact clinical examination indexes of splenic immune function.     

肠-腔-房转流术治疗混合型布加综合征的疗效分析

Objective To investigate the therapeutic effect of the meso-cavo-atrial shunt (MCAS) in the treatment of combined Budd-Chiari syndrome (BCS). Methods The clinical data of 17 cases of combined BCS with all or bilateral hepatic vein occlusion and long range occlusion or obstruction of inferior vena cava (IVC) were admitted to the Qilu Hospital from February 2000 to May 2004. All patients were treated by MCAS with artificial blood vessels. The pre- and postoperative clinical symptoms, the IVC and portal venous (PV) pressures, the incidence of postoperative complications and the patency rate of the artificial vessels were analyzed. The survival of patients was analyzed using the Kaplan-Meier analysis, and the data were analyzed using the chi-square test and t test. Results No patient died during the perioperative period, and the symptoms of 15 patients disappeared or were relieved after operation, with a significant difference compared with those before operation (χ2 =9.78, P <0. 05 ). Three patients had complications after the operation. The postoperative PV and IVC pressures were decreased by 1.2 cm H2O (1 cm H2O =0.098 kPa) and 18.5 cm H2O, respectively. There were significant differences in the decrease of IVC and PV pressures ( t = 2.38, 3.06, P < 0.05 ). The 1-, 3-, 5-year survival rates were 16/17, 15/17 and 14/17, respectively, and the 5-year patency rate of the artificial vessels was 14/17.Conclusions MCAS can simultaneously relieve IVC and PV hypertension for patients with combined BCS. The postoperative complication rate was decreased, the 5-year survival rate and the patency rate of the artificial vessels were improved after the treatment, so MCAS is an optional surgical method for treating combined BCS.     

中、晚期胰头癌综合治疗疗效分析

目的 探讨胰头癌手术切除率，复发，转移及生存时间，生活质量等相关因素。方法 本院自1980年-2000年收治胰头癌136例，其中27例行胰十二指肠切除术，15例行术前放疗。11例行术后导管化疗。结果 1980年-1998年胰头癌共99例，行手术切除16例，手术切除率16.2%(16/99),1998年-2000年收治37例采用综合治疗，术前放疗，手术，术后导管介入化疗，使手术切除率明显提高到29.7%（11/37），复发，转移时间延长，1年生存率分别为50%，58%，3年生存率为15%，18%。结论 综合治疗可明显提高手术切除率，能改善生活质量，但对生态率无显著改观。     

腹腔积液对闭合性腹外伤患者空腔脏器损伤的诊断价值

目的:探讨腹腔积液对闭合性腹外伤患者空腔脏器破裂的诊断价值。方法:采用腹腔穿刺、腹部X线透视、B超及CT检查闭合性腹部外伤患者中非实质性脏器损伤128例,分析腹腔积液在空腔脏器损伤时的发生率及其临床意义。结果:术前检查发现腹腔积液101例(78.9%),B超发现腹腔积液81例(63.3%)。腹腔游离气体27.3%。B超对腹腔积液有较高的确诊率。结论:腹腔积液是诊断腹部空腔脏器损伤的重要征象。     

hTERT在胃良恶性病变中的表达及临床意义

目的:探讨人端粒酶逆转录酶(hTERT)在胃良恶性病变组织中的表达及临床意义.方法:收集经手术和胃镜病理确诊的不同病变类型的胃组织标本126例,其中正常组织10例,慢性胃炎26例,胃良性溃疡22例,胃平滑肌瘤5例,胃增生性息肉3例,胃癌50例,胃恶性淋巴瘤2例,胃间质瘤8例.胃癌前病变,不典型增生54例,其中低度18例,中度25例,重度11例.采用免疫组织化学SP法分别测定hTERT在各类病变组织中的表达,对各指标阳性表达率与临床病理因素的关系进行比较分析.结果:hTERT在正常和良性病变胃组织中无或很少表达,在恶性病变中呈强阳性表达(P<0.05),且在癌变过程中表达水平随黏膜病变程度加重逐渐增高.在胃癌组织中,hTERT的表达与患者年龄、性别、肿瘤大小及位置、组织病理类型无关;与肿瘤浸润深度、组织分化程度、淋巴结转移及Bormann分型、远处转移密切相关.结论:hTERT的表达与胃恶性病变的发生密切相关,尤其是在胃癌的发生发展中具有重要意义.其表达程度可代表胃癌的侵袭转移能力,对胃癌的早期诊断具有重要的临床价值,有可能成为胃恶性病变基因或免疫治疗的有效靶点.