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Cell growth kinetics and changes in AFP in nude mice with human hepatoma xenografts were evaluated using the flow cytometry method. After receiving 10 Gy of radiation, the mice showed a marked delay in tumor growth; approximately 1 Gy of radiation caused a tumor growth delay of one day. Irradiation altered various phases of the cell cycle. An acute and temporary block of G2 cells was characteristic; FCM measurements demonstrated that about 58% of cells were blocked in the G2 phase and this blocking effect lasted 90 hours after an irradiation of 10 Gy. This indicated that human hepatoma xenografts in nude mice were quite sensitive to irradiation. It was also noted that the AFP decreased for 96 hours after irradiation. Changes in G2 cells after irradiation may be closely related to changes in AFP. 相似文献
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应用流式细胞计检测第33代人鼻咽癌裸鼠移植瘤的中心与外周部位DNA含量。结果表明:较大肿瘤(瘤重≥0.59g)的中心部位DNA含量高于外周部位(P<0.05),而较小肿瘤(瘤重<0.59g)不同部位的DNA含量无明显差异;且瘤重≥0.27g的肿瘤,其中心部位的增殖指数低于周边部位(P<0.05)。 相似文献
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目的研究肺癌细胞DNA倍体类型和核仁组织区嗜银蛋白(AgNOR)及两者之间的相互关系。方法对36例肺癌石蜡标本进行细胞AgNOR定量计数和DNA含量的流式细胞术(FCM)检测。检测结果进行t检验和X2检验。结果二倍体肺癌细胞AgNOR计数(1.65±0.87)显著低于异倍体肺癌细胞者(3.09±1.03)细胞周期中S期细胞<20%的肺癌细胞AgNOR计数(1.38±1.02)显著低于S期细胞≥20%者(2.77±1.14)。在二倍体肿瘤中,分化Ⅱ级和Ⅲ级细胞的AgNOR计数显著高于分化Ⅰ级者,但在Ⅱ、Ⅲ级之间AgNOR计数则无显著差异;分化Ⅲ级肿瘤的异倍体检出率显著高于分化Ⅰ、Ⅱ级肿瘤,但在Ⅰ、Ⅱ级之间异倍体检出率则无显著差异。结论细胞DNA含量和AgNOR计数与肺癌细胞的增殖状态、恶性程度及预后有密切相关性;在病理分级中以上两种检测具有互补性。 相似文献
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