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目的 分析实体肿瘤患者贫血发生情况、贫血类型、铁代谢状况、前白蛋白水平的变化情况及其之间的相关性.方法 对2007年7月至2010年4月期间我院收治的370例恶性实体肿瘤患者的临床资料进行回顾性分析.结果 370例肿瘤患者中有206例存在贫血,发生率55.67%(206/370),其中轻度贫血129例,中、重度贫血77例,后者血清铁明显降低[(8.37±6.09)μmol/L];血清铁蛋白增高[(474.57±327.58)μg/L];血清铁降低与贫血程度有相关性(P<0.05),而不同程度贫血之间血清铁蛋白差异无统计学意义(P>0.05);所有贫血患者中,前白蛋白下降187例(90.77%),贫血下降的程度与前白蛋白下降未显示有相关性(P>0.05).结论 恶性实体肿瘤患者贫血发生率较高,而且以正细胞正色素性贫血为主,与铁代谢障碍有关,与前白蛋白水平无相关性.Abstract: Objective To explore the occurrence of anemia, anaemia type, iron metabolism situation,variation of serum Prealbumin (PA), and the relationship among them in cancer patients. Methods Three hundred and seventy cancer patients, admitted from July 2007 to April 2010 to our hospital, were enrolled into the study. The clinical data of all subjects were analyzed retrospectively. Results The incidence of anemia in 370 patients was 55.67% (206/370). Among all 206 anemia cases,129 cases had mild anaemia and 77 cases had middle to severe anaemia. In the last group ( n = 77 ), we found significant decrease in serum iron level ( [ 8. 37 ± 6. 09 ] μmol/L) and increase in serum ferritin level ( [ 474. 57 ± 327. 58 ] μg/L); and the correlation between serum iron and the anemia degree( Ps < 0. 05 ). However, we found no significant differences of serum ferritin level between the groups with different degree of anemia(P >0. 05). Among all 206 anemia cases ,187(90. 77% ) patients had a low level of serum PA, but no relationship between the degree of anemia and the drop of serum PA ( P > 0. 05 ). Conclusion The anemia was very popular in cancer patients, which had correlation with iron metabolism situation but not PA. 相似文献
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目的探讨中晚期肿瘤患者并发血栓栓塞的相关因素、临床特点、诊断及治疗方法。方法以53例恶性肿瘤并发血栓栓塞患者为病例组,收集同期不伴有血栓栓塞的30例恶性肿瘤患者作为对照组,回顾性分析两组患者的临床资料,对栓塞部位、血小板、D-二聚体及纤维蛋白水平等进行分析。结果病例组53例患者中,下肢深静脉血栓27例,上肢深静脉血栓6例,肺栓塞13例,脑栓塞4例,门静脉栓塞2例,脾静脉栓塞1例,15例治愈,22例好转,总有效率为69.8%。结论恶性肿瘤临床分期晚、发生远处转移、D-二聚体水平升高、合并心脑血管疾病,与患者血栓栓塞的发生相关。 相似文献
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目的观察多西他赛加或不加顺铂治疗老年晚期胃癌的近、远期疗效和毒副反应。方法19例老年晚期胃癌患者采用单药多西他赛加或不加顺铂化疗,每例患者最少完成2周期;另外随机取同期患者10例予以最佳支持治疗作为对照;每2周期观察疗效、不良反应、并随访2年。结果治疗组患者总有效率42.1%,其生活质量明显改善,毒副作用可耐受,中位生存期长于最佳支持治疗组,显示更好的生存获益(P〈0.05)。治疗组的稳定好转率为73.7%明显优于对照组的30%(P〈0.05)。2组生存期比较差异有统计学意义(P〈0.05)。结论老年晚期胃癌患者同样可以从化疗中获益。单药多西他赛化疗耐受性良好,有一定疗效,适用于高龄,体能状况较差的患者。 相似文献
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