单倍型供者淋巴细胞输注治疗复发性急性白血病

Objective To evaluate the effect of haploidentical lymphocyte infusion on refractory and relapse acute leukemia. Methods The haploidentical donor lymphocyte infusion was used to treat for relapse acute myeloid leukemia 3 patients (M2 2 eases, M4 lcase), one relapse acute lymphocyte leukemia from April 2006 to October 2007. Four cases who had accepted secondly regimens were ineffective,after relapse. Collecting donor lymphocytes, parents children as donor supply in 3 cases, mother as donor supply one case. Before donor lymphocyte infusion patients received chemotherapy of different regimens. Donor haploidentical iymphocytes irradiated by 6-8 Gy radial were infused when patients white cell count was at the lowest after the chemotherapy. The average of infusion cells was 2.3 (1.4-3.1)×108/kg. Results One patient acquired complete remission and two patients were effective in three relapse acute myeloid leukemia. It was ineffective in relapse acute lymphocyte leukemia. No transfusion related graft versus host disease was observed. One patient has had herpes zoster virus infection. Conclusion Haploidentical donor lymphocyte infusion with chemotherapy are effective for refractory and relapse in acute myeloid leukemia, but the infused cell quantity and irradiated dosage must be further discussed.     

单倍型供者淋巴细胞输注治疗复发性急性白血病

Objective To evaluate the effect of haploidentical lymphocyte infusion on refractory and relapse acute leukemia. Methods The haploidentical donor lymphocyte infusion was used to treat for relapse acute myeloid leukemia 3 patients (M2 2 eases, M4 lcase), one relapse acute lymphocyte leukemia from April 2006 to October 2007. Four cases who had accepted secondly regimens were ineffective,after relapse. Collecting donor lymphocytes, parents children as donor supply in 3 cases, mother as donor supply one case. Before donor lymphocyte infusion patients received chemotherapy of different regimens. Donor haploidentical iymphocytes irradiated by 6-8 Gy radial were infused when patients white cell count was at the lowest after the chemotherapy. The average of infusion cells was 2.3 (1.4-3.1)×108/kg. Results One patient acquired complete remission and two patients were effective in three relapse acute myeloid leukemia. It was ineffective in relapse acute lymphocyte leukemia. No transfusion related graft versus host disease was observed. One patient has had herpes zoster virus infection. Conclusion Haploidentical donor lymphocyte infusion with chemotherapy are effective for refractory and relapse in acute myeloid leukemia, but the infused cell quantity and irradiated dosage must be further discussed.     

肺癌患者超声引导下PICC置管影响因素的Logistic回归分析

目的对肺癌患者超声引导下PICC置管后非计划拔管影响因素的Logistic回归分析,探讨相关危险因素。方法选取我院需行PICC置管的肺癌患者84例为研究对象,不成功组21例,为非计划拔管患者,成功组63例,未出现非计划拔管,两组患者均采用超声引导下PICC置管,对两组患者的基本资料和住院资料进行赋值后进行Logistic回归分析,分析非计划拔管的危险因素。结果共计84例患者,均成功置管,成功率为100%。对两组患者置管影响因素进行Logistic回归分析,在因素伴发疾病(1种)方面比较(χ~2=3.910,P=0.048)、治疗方法(手术联合化疗)(χ~2=4.973,P=0.026)、治疗方法(放化疗结合)(χ~2=4.507,P=0.034)、置管类型(χ~2=7.756,P=0.005)、置管静脉选择(肘正中静脉)(χ~2=5.325,P=0.021)、置管静脉选择(头静脉)(χ~2=4.895,P=0.027)、制动时间(χ~2=9.724,P=0.002)、总留置时间(1-4周)(χ~2=27.177,P=0.000)、总留置时间(4-12周)(χ~2=4.675,P=0.031)、总留置时间(12周以上)(χ~2=8.671,P=0.003)、带管住院次数(2-3次)(χ~2=18.599,P=0.000)、带管住院次数(3次以上)(χ~2=12.392,P=0.000)、患者状态(χ~2=10.934,P=0.001),比较中,均具有统计学意义(P0.05)。结论超声引导下对肺癌患者进行PICC置管,具有极高的置管成功率;同时,患者的伴发疾病,置管类型,置管静脉选择,制动时间,总留置时间,带管住院次数,患者精神状态等因素是造成非计划拔管的危险因素,在PICC置管中,要进行综合考虑。     

单倍型供者淋巴细胞输注治疗复发性急性白血病

 目的　探讨难治性复发性急性白血病单倍型淋巴细胞输注的疗效。方法　2006年4月至2007年10月应用单倍型淋巴细胞输注治疗复发性急性髓性白血病（AML）3例（M2 2 例,M4 1例）,复发性急性淋巴细胞白血病（ALL）1例,4例复发患者在二线方案化疗无效后,采集供者淋巴细胞,子女供父母3例,母供子1例,供者淋巴细胞在输注前,患者再次接受了不同方案的化疗,白细胞较低时输注供者的淋巴细胞,平均输注细胞2.3（1.4～3.1）×108／kg,输注前淋巴细胞接受了6～8 Gy 60Coγ射线照射。结果　3例AML患者1例获得了完全缓解（CR）,2例有效,1例ALL无效。4例患者输注单倍型供者淋巴细胞后无移植物抗宿主病的发生,未出现严重的骨髓抑制,1例患者发生了带状疱疹病毒感染。结论　单倍型供者淋巴细胞输注配合化疗对难治复发的AML有疗效,输注细胞的数量及照射的剂量需进一步探讨。     

单倍型供者淋巴细胞输注治疗复发性急性白血病

Objective To evaluate the effect of haploidentical lymphocyte infusion on refractory and relapse acute leukemia. Methods The haploidentical donor lymphocyte infusion was used to treat for relapse acute myeloid leukemia 3 patients (M2 2 eases, M4 lcase), one relapse acute lymphocyte leukemia from April 2006 to October 2007. Four cases who had accepted secondly regimens were ineffective,after relapse. Collecting donor lymphocytes, parents children as donor supply in 3 cases, mother as donor supply one case. Before donor lymphocyte infusion patients received chemotherapy of different regimens. Donor haploidentical iymphocytes irradiated by 6-8 Gy radial were infused when patients white cell count was at the lowest after the chemotherapy. The average of infusion cells was 2.3 (1.4-3.1)×108/kg. Results One patient acquired complete remission and two patients were effective in three relapse acute myeloid leukemia. It was ineffective in relapse acute lymphocyte leukemia. No transfusion related graft versus host disease was observed. One patient has had herpes zoster virus infection. Conclusion Haploidentical donor lymphocyte infusion with chemotherapy are effective for refractory and relapse in acute myeloid leukemia, but the infused cell quantity and irradiated dosage must be further discussed.     

急性白血病院内感染因素探讨

目的 :探讨急性白血病院内感染相关因素。方法 :详细观察病人感染时间、部位、感染源及白血病类型。结果 :急性白血病院内感染与白血病类型、化疗强弱、白细胞数的高低有明显关系。结论 :急性白血病易并发各种院内感染 ,尤以革兰氏阴性杆菌常见     

单倍型供者淋巴细胞输注治疗复发性急性白血病

Objective To evaluate the effect of haploidentical lymphocyte infusion on refractory and relapse acute leukemia. Methods The haploidentical donor lymphocyte infusion was used to treat for relapse acute myeloid leukemia 3 patients (M2 2 eases, M4 lcase), one relapse acute lymphocyte leukemia from April 2006 to October 2007. Four cases who had accepted secondly regimens were ineffective,after relapse. Collecting donor lymphocytes, parents children as donor supply in 3 cases, mother as donor supply one case. Before donor lymphocyte infusion patients received chemotherapy of different regimens. Donor haploidentical iymphocytes irradiated by 6-8 Gy radial were infused when patients white cell count was at the lowest after the chemotherapy. The average of infusion cells was 2.3 (1.4-3.1)×108/kg. Results One patient acquired complete remission and two patients were effective in three relapse acute myeloid leukemia. It was ineffective in relapse acute lymphocyte leukemia. No transfusion related graft versus host disease was observed. One patient has had herpes zoster virus infection. Conclusion Haploidentical donor lymphocyte infusion with chemotherapy are effective for refractory and relapse in acute myeloid leukemia, but the infused cell quantity and irradiated dosage must be further discussed.     

难治性急性白血病大剂量化疗的护理

急性非淋巴细胞白血病用经典方案化疗2个疗程未完全缓解,急性淋巴细胞白血病用经典方案诱导4～5周末完全缓解即为难治性白血病.难治性白血病只有用大剂量化疗或更强的化疗方案才能使其达到缓解,搞好临床护理尤其重要.为此,将我科应用大剂量化疗治疗难治性白血病病人的护理体会总结如下：……     

积极认知行为疗法对乳腺癌化疗患者心理状态及生活质量的影响

目的探讨乳腺癌化疗患者的心理状态及实施积极认知行为疗法（ACBT）对心理状态及生活质量的影响。方法采用随机数字表法将58例乳癌化疗患者随机分为两组,实验组（n=28）采用化疗药物治疗同时联合ACBT治疗,对照组（n=30）单纯采用化疗药物治疗。首次化疗第1天及治疗后6个月,采用Zung焦虑量表（SAS）、抑郁量表（SDS）、生活质量核心问卷（QLQ—C30）评定两组患者干预前后心理状态及生活质量。结果实验组干预后SAS评分为（42．21±4．83）分,SDS评分为（41．43±5．62）分,对照组分别为（45．15±4．68）分和（45．78±9．25）分,组间比较差异具有统计学意义（t=2．35,2．19;P〈0．05）。两组生活质量核心问卷中躯体功能、角色功能、情绪功能、认知功能、社会功能、疼痛、疲劳、恶心、呕吐、失眠、总的健康状况比较差异有统计学意义（P〈0．05）,气促、食欲、便秘、腹泻症状比较差异无统计学意义（P〉0．05）。结论在化疗药物治疗基础上联合ACBT治疗可减轻乳癌患者的抑郁和焦虑症状,改善患者康复过程中的心理社会适应能力,提高生活质量。