阑尾粘液性囊腺瘤癌变二例

阑尾粘液性囊腺瘤癌变二例徐光炜，刘宝珠，刘燕平，虞积耀，胡瑞民例１女，６２岁。１９６３年行阑尾切除术，术后３年发现右下腹包块，逐渐增大。１９８４年５月手术，术中见回盲部有１２ｃｍ×１８ｃｍ×４ｃｍ囊性肿物，与周围广泛粘连，行右半结肠切除。病理诊断为阑...     

阑尾粘液性囊腺瘤癌变二例报告

阑尾粘液性囊腺瘤癌变二例报告徐光伟，刘宝珠，虞积耀，胡瑞民例１女，６２岁。１７年前行阑尾切除术，术后三年发现右下腹部肿块，逐渐增长。１９８４年５月因突发腹部剧痛，急诊入院手术。腹痛以右下腹为重。术中见腹腔内有多量混浊黄色液体，回盲部有一１２ｃｍ×８ｃ...     

PROLIFERATION RATE OF COLONIC NEOPLASMS AND MUCOSA ADJACENT TO NEOPLASMS: IMMUNOHISTOCHEMICAL STUDY

Biopsy specimens of normal mucosa (n=5). adenomas (n -13), adenocarcinomas (n = 8). mucosa adjacent to adenoma (n=10) mucosa adjacent to adenocarcinoma (n = 7 ) at the large bowel were investigated by an iminunohistochemical method using 5- bromodeoxynldine (BrdUrd) . The labeling index (LI) was significantly lower in normal nucosa than mucosa adjacent to neoplasms and adenomas and adenocarcinomas. The proliferative zone was confined to the lower two- third at the crypt in normal mucosa and in mucosa adjacent to neoplasms. The labeled cells were either present in the upper third or scattered along the crust and in surface epithelium. The results support the adenmo-carcinoma sequence.     

溃疡性结肠炎中异型增生与癌变——组织学、组织化学及免疫组织化学研究

本文收集58例溃疡性结肠炎活检标本137块,手术切除溃疡性结肠炎大肠标本3例。其中2例发生癌变,取材133块,应用 HE,AB/PAS,HID/AB,PAT/KOH/PAS 染色及以大肠癌单克隆抗体 MC_3和4D_6的免疫组织化学方法观察溃疡性结肠炎粘膜异型增生及癌变的粘液变化、肿瘤抗原的分布。病变分为五组:无异型增生、轻度异型增生、中度异型增生、重度异型增生、癌变。结果表明,随着异型增生的加重肿瘤抗原的检出阳性率增加,而且氮乙酰化唾液酸及有邻位羟基 C_7,C_9的氧乙酰化唾液酸粘液也增多,这种粘液在 PAT/KOH/PAS 染色中呈蓝色,作者认为,当溃疡性结肠炎出现异型增生时,结合 PAT/KOH/PAS 组织化学染色蓝色及应用大肠癌肿瘤抗原检测结果,对判断恶变及预后可提供有价值的参考指标。