THE SENSITIVITY OF EHRLICH ASCITIC CARCINOMA CELLS TO THE EMPERIPOLESIS OF THYMUS LYMPHOCYTES

In mixed lymphocyte-tumor all culture in vitro, the ability of thymus lymphocytes adhering to tumor cells was found to be essentially consistent with its emperipolesis index, though not synchronous. Tumor cells at different progressive stages and in the mixed cultures with or without Con A stimulation also varied in the sensitivity to lymphocyte adhesion and emperipolesis. Tumor adhesiveness anl emperipolesis of theymus lymphocytes and their PNA-, PNA subgroups were shown to be different significantly from splenic lymphocytes. Thymosin exhibited certain promotive effect on lymphocyte-tumor adhesion and emperipolesis.     

胸腺淋巴细胞“钻”肿瘤细胞的形态观察

<正> 体内的致敏T淋巴细胞具有杀伤恶性肿瘤细胞的作用。在体内外均可察见淋巴细胞“钻入”(emperipolesis)瘤细胞;这种奇特的生物学现象可能是淋巴细胞或其某一亚群的自然本能。它对肿瘤的发生、发展能产生一定的影响。“钻”瘤作用与淋巴细胞的细胞毒功能呈正相关。胸腺是T细胞发育的主要场所,它所产生的T细胞与肿瘤细胞接触后而致敏,增强其增殖反应,同时可迅速将肿瘤细胞杀伤和溶解。本文报告小鼠 Ehrlich腹水癌细胞作为刺激细胞,自身胸腺淋巴细胞作为效应细胞,按比例混合培养,对胸腺淋巴细胞“钻”肿瘤细胞的现象作形态观察。结果显示淋巴细胞主动向瘤细胞移动,并相互接触,最后“钻入”瘤细胞内使肿瘤细胞解体。其“钻”瘤指数及电镜观察将另文报道。