妊娠中毒症胎盘病变的初步观察

妊娠中毒症的病因学是产科中一项未解决的问题。近年来很多学者都认为胎盘是所谓“毒素”的来源。本工作的目的在于分析调查妊娠中毒症胎盘的病理变化,以促进对病因学的进一步探讨。材料及方法材料取自北医第一附属医院,第三附属医院及海淀医院住院分娩产妇的胎盘,依据临床诊断分为四组:(1)正常,未合并血压升高;(2)急性妊娠中毒症(包括妊娠肾病,先兆子癎及子癎);(3)慢性高血压合并妊娠;(4)胎盘早期剥离。     

卵巢未成熟畸胎瘤(33例临床病理分析)

本文对我科1966～1983年收治的33例未成熟畸胎瘤进行了临床病理分析。本研究资料表明:充分地病理检查对分级、治疗及预后都十分重要;临床分期和病理分级与预后有关,但病理分级,尤其是转移瘤的病理分级与预后关系最密切。对年轻患者可行单侧附件切除及联合化疗。手术和化疗可能争取畸胎瘤由不成熟向成熟转化的机会。     

FLOW CYTOM ETRIC ANALYSIS OF CELLULAR DNA CONTENT IN EPITHELIAL OVARIAN TUMOR

The DNA content of tumor all was analyzed by flow cytometry on parafflnembedded specimens in 73 patients with epithelial ovarian tumor, and its clinical significance was evaluated. One of the 5 benign (20%), 2 of the 11 borderline (18.18%), and 30 of the 57 malignant (52. 63%) tumors were aneuplold. The occurrence rate of aneuploidy In malignant tumors was higher than In benign and borderline tumors ( P < 0. 05 ). Furthermore, aneuploidy was more frequently In the advanced stages (Ⅲ -Ⅳ ) (77. 7%) than in the early stages (Ⅰ - Ⅱ ) (9. 5%) (P<0. 005). The occurrence rate of DNA aneuploidy was higher in patients associated with ascites and the residual tumor≥.2 cm. Patients with aneuploid tumors had more of ten ascites (P<0. 005) and residual tumor size≥2cm (P< 0.005). There was no apparent correlation between the DNA ptoidy and the histologic grade, histologic type of the tumors. G0/G1 cell proportion of DNA diplold tumors in advanced carcinoma (64. 6%) was less than those of early stage carcinoma (     

卵巢恶性上皮性肿瘤细胞DNA含量的研究

应用流式细胞术对57例卵巢上皮性癌,进行了细胞DNA含量测定并探讨其临床意义。结果:晚期痛异倍体率(77.7%)高于早期者(9.5%),P<0.01,且细胞增殖活跃。多因素分析显示DNA含量是影响预后的最重要因素,P=0.007,二倍体肿瘤患者生存时间长。本文认为DNA含量反映了肿瘤自身的生物学特性,DNA倍体测量有助于了解病人预后。     

BORDERLINE MUCINOUS AND SEROUS TUMORS OFOVARY

273 cases of mucinous ovarian tumors and 221cases of serous ovarian tumors were reviewed. Afterexcluding those of benign tumors, the remaining 48and 44 cases were dividcd into three groups: bordcrIinc malignancy, local malignancy and carcinoma.The results of clinicopathologic analysis revealedthat the borderline malignancy and local malignancylesionsi wcrc similar in clinical behaviors but different in benignancy and malignancy in pathology.They appeared to be malignant clinically, but wereso indolent that they had much less extraovarianspread and more favorable prognosis than carcino mas. The conccpt of borderline tumors must includetwo groups of tumors. One is the benign tumorsbordering malignancy named the 6borderline malig nancy' and the other is the malignant tumors bordering benignancy named 6the local malignancy'. Thetumors of borderline malignancy and local malig nancy are in the nature of one category of lcsioiisiii the borderline zone between benign and ma lignant varieties. The histologic criteria for borderline malignancy, local malignancy and carcinoma weresummed up by experience. The unquestionablemalignancy criteria were indicated and the signi- ficance of stromal invasion for diagnosis of carcino-ma was discussed.     

卵巢上皮性癌DNA含量的异质性

应用流式细胞术对22例卵巢上次性癌石蜡包埋标本进行了DNA含量测定,每例测2～5个标本,以了解原发肿瘤不同区域、原发癌与转移病灶DNA含量是否一致。结果原发肿瘤内不同区域其DNA指数(DNA index,DI)相同,原发癌与转移灶的DNA指数在14例病人中有13例相同,7例双侧卵巢肿瘤中5例两侧DI不同。本文认为卵巢肿瘤细胞的DNA含量是一个稳定的指标,同一病人肿瘤不同部位DI变异(DNA异质性)可能与肿瘤的多中心发生有关,对每例病人应多点取材测定。