基于PubMed数据库的胃肿瘤研究现状及热点#br# 聚类分析#br#

Abstract To investigate the current status and hotspots in the field of gastric neoplasms in recent years. Methods The literatures related to gastric neoplasms from 2016-2021 were searched in PubMed database, The Bicomb software and gGLUTO software were used for cluster analysis and the status quo and research hotspots of gastric neoplasms were analyzed. Results A total of 18982 articles were included. The annual number of publications from 2016 to 2021 was 4040, 3847, 4021, 4133, 2648 and 293, respectively. Gastric Cancer had the largest number of publications. Among the literature source countries, western countries and Japan had the most publications. A total of 79 high-frequency subject headings were selected, and 10 clusters were obtained after cluster analysis. Conclusion The international research hotspots of gastric neoplasms mainly focus on adenocarcinoma of esophagogastric junction, Helicobacter pylori treatment, targeted drugs, laparoscopy, endoscopic treatment and so on. Western countries and Japan play a critical role in leading the development of research in this filed, and our country has a long way to catch up with them.     

肿瘤大小与肝细胞癌患者死亡风险关联强度剂量反应关系

目的 探讨肿瘤大小与肝细胞癌（Hepatocellular carcinoma, HCC）患者死亡风险关联强度的剂量反应关系。方法 回顾性收集2010-2015年美国国立癌症研究所的监测数据、流行病学和最终结果（Surveillance, epidemiology and end results, SEER）数据库中HCC患者的临床资料。根据四分位数法将肿瘤大小分为Q1~Q4 四组,采用限制性立方样条模型分析肿瘤大小与HCC患者死亡风险关联的剂量反应关系。结果 共15 985例患者符合标准纳入分析。调整混杂因素后,Cox回归显示,Q1组 (<30 mm)、Q2组 (30~49 mm)、Q3组 (49~81 mm)和Q4组 (>81 mm) 的HR值（95% CI）分别为1.00、1.31 (1.23~1.39)、1.60 (1.50~1.70)、2.02 (1.89~2.16),趋势性检验差异有统计学意义（〖XC小五号.EPS;P〗=20.371,P<0.001）。限制性立方样条模型结果显示,肿瘤大小与死亡风险的关联强度呈非线性的剂量反应关系（χ2=11.220,P<0.001）。结论 肿瘤大小与HCC患者死亡风险关联强度呈非线性的剂量反应关系。