DYNAMIC ANALYSIS OF O R GANICACIDS IN EXTRACELLULARFLUIDS OFHUMAN DENTAL PLAQUES

Organic acids in unstimulated saliva and extracellular fluids of dental plaques from 12 middle school students were measured by ion-chromatography. The acids in the plaques were analyzed before and 5-10, 30-35, 60-65 minutes after rinsing with 10% sucrose solution. The differences of the acids between the extracellular fluids of resting plaques and unstimulated saliva were significant. In the extracellular fluids of plaques, the concentration of high pK acids, i.e. acetic and propionic acids was higher than that of low pK acids i.e., lactic and formic acids before and after sucrose rinse. The relations of time-dependent changes between the ratio of low pK to high pK acids and pH were observed in the extracellular fluids of plaques after sucrose rinse. No significant difference of lactic acid concentrations was found between the caries-active and caries-free subjects 30-35 minutes after sugar rinse. The concentration of acetic acid was much higher in the extracellular fluids of dental plaque at any time. It is suggested that there may be some relationship between acetic acid and caries process.     

电视一族的贴身病

人们往往认为，生了病总是卧床休息为好。然而，医学研究认为这是一种偏见。美国教授米特彻尔研究了卧床休息及其对疾病影响问题，得出结论认为：生病的人卧床越久，健康退化越快；卧床过久使心脏功能减退，血液循环缓慢，肌肉组织松弛，体力渐衰等，弊多利少。     

磁共振弥散加权成像在肝脏疾病中的临床应用

弥散加权成像(diffusion weighted imaging,DWI)是目前能在活体上进行水分子弥散测量与成像的惟一方法,反映了水分子的微观运动状况.DWI对中枢神经系统特别是脑缺血的临床价值已被广泛肯定,随着磁共振技术的发展,DWI的应用也从神经系统向全身其他系统推广.本文着重阐述磁共振弥散加权成像的原理及其在肝脏中的应用.     

鼻咽癌弥散加权成像临床研究

目的 探讨弥散加权成像(DWI)对鼻咽癌原发灶及其转移性淋巴结的诊断价值,建立ADC值对鼻咽癌原发灶和颈部转移性淋巴结的诊断阈值.方法 连续对56例鼻咽癌初诊患者和55例健康志愿者行MRI常规扫描和DWI扫描.鼻咽癌患者均行鼻咽部活检和图像引导下颈部淋巴结穿刺.检测56例鼻咽癌原发灶及其颈部转移性淋巴结和55例志愿者的鼻咽壁及其颈部淋巴结的ADC值、eADC值并行比较.结果 56例患者原发灶均经病理诊断为非角化型癌,其中51个颈部淋巴结阳性.健康志愿者检出75个颈部淋巴结.鼻咽癌患者原发灶及其转移性颈部淋巴结的ADC值均低于健康志愿者,eADC值均高于健康志愿者.ADC值≤0.809×10-3 mm2/s作为诊断鼻咽非角化型癌原发灶的阈值,其敏感性为80.4%,特异性为74.5%,阴性预测值为79.2%,阳性预测值为77.6%,准确性为78.4%.ADC值≤0.708×10-3 mm2/s作为诊断淋巴结转移的阈值,其敏感性为43.1%,特异性为93.3%,阴性预测值为70.7%,阳性预测值为81.5%,准确性为73.0%.结论 弥散加权成像对鼻咽癌原发灶及其转移性淋巴结有一定诊断价值.     

肺癌化疗药物相关不良反应回顾性分析

<正>据2020年全球数据统计,肺癌发病率位居第二,死亡率位居第一~[1]。而国内的情况则更加严峻,其发病率和死亡率均为第一~[2]。化疗是肺癌治疗的主要手段之一,而化疗药物毒性大,极易发生药物不良反应,成为除疾病本身之外影响肺癌患者生存质量的又一重大因素~[3]。因此,通过高质量的不良反应报告数据来探究该类药物不良反应发生特点,据此寻求防治方法是提高肺癌患者生活质量的重要途径。