肺鳞癌治疗新靶点FGFR的研究进展

肺癌是目前全球发病率和死亡率均居前列的恶性肿瘤，其中肺鳞癌经手术、放化疗等综合治疗后，其疗效仍不满意。随着分子靶向治疗在肺腺癌中取得了令人瞩目的成果，而肺鳞癌患者中EGFR基因突变及ALK融合基因少见，急需探索新的靶点指导肺鳞癌患者的临床治疗。研究表明，FGFR家族（FGFR1-4）是肺鳞癌中突变频率较高的基因，FGFR基因的激活突变和扩增与肺鳞癌的发生和发展密切相关，同时许多小分子 FGFR 抑制剂在临床应用中已经取得较好的治疗效果。目前，许多FGFR抑制剂治疗肺鳞癌的临床试验也正在进行研究，针对FGFR靶点的基因治疗可为肺鳞癌的治疗提供一种新的策略。本文就FGFR在肺鳞癌的靶向治疗中的最新研究进展进行综述。     

“理气化瘀，软坚增免”治疗子宫腺肌病40例

子宫隙肌病是妇科常见病多发病属于祖国医学“痛经，徵瘕”的范畴，我们采用“理气化瘀，软坚增免”作为根本法则，自拟方剂“溯源追本汤”，其组方为柴胡、木香、元胡、没药、蒲黄、五灵脂、生山楂、黄芪、赤芍、茯芩、炙鳖甲、桂枝等随证加战，治疗40例子宫腺肌病患者取得了非常好的效果．     

产后产妇300例心理状态调查及应对措施

根据现代医学模式，健康的标准是躯体健康，心理健康和社会适应良好。妇女在妊娠期、分娩期和产褥期承受着躯体和精神上的巨大压力；产后由于身体的变化、社会角色的改变，对产妇的认知、情感、行为具有明显影响。焦虑是人们对环境中一些即将面临的，可能会造成危险和威胁的重大事件，或者要做出重大努力的情况中进行适应时，心理上出现紧张和一种不愉快的期待。探讨产后产妇的心理状态变化及其原因，采取有效的应对措施，以保证产妇的健康及至婴幼儿的健康成长。     

Pediatric intracranial aneurysms——clinical characteristics and therapeutic strategies

Objective To assess the radiological characteristics and therapeutic strategies of intracranial aneurysms in children. Methods From our dedicated neurovascular databank of patients, we reviewed 23 consecutive children who had 24 intracranial aneurysms. There were 14 boys and 9 girls with a mean age of 9.09 years ( range 1 - 14 years ). Results Intracranial aneurysms in children ≤ 14 years constituted 1.3% of all intracranial aneurysms. Internal Carotid artery (ICA) and middle cerebral artery (MCA) were the most frequent sites for aneurysms. About 58.3% of the aneurysms were complex, including dissecting, pseudoaneurysm, giant and fusiform aneurysm. 1/3 of all aneurysms were located in posterior circulation. Only 1 case had multiple aneurysms in this case series. Almost half of all cases presented with subarachnoid hemorrhage and others presented with mass effect. 14 cases underwent endovascular treatment. 4 patients received microsurgical therapy. 5 cases did not receive microsurgical or endovascular therapy, 2 of them whose aneurysms spontaneously thrombosed during follow up. One boy with left vertebral artery giant aneurysm died after endovascular therapy owing to gradual thrombosis in basilar artery. Another child had poor outcome because of rerupture of aneurysm before operation. Whereas the majority had a favorable outcome. Conclusions Intracranial aneurysms in children had many clinical and radiological characteristics different from those in adults : ( 1 ) remarkable male predominance; ( 2 ) ICA and MCA were the most common sites for aneurysms; (3) high incidence of large, traumatic, infectious, dissecting and fusiform aneurysms. (4)For pediatric intracranial aneurysms, both microsurgical approaches and endovascular treatment were effective. Endovaacular therapy was the best choice for complex aneurysms.     

诺和锐胰岛素治疗儿童1型糖尿病的临床观察

目的:观察诺和锐胰岛素治疗儿童1型糖尿病的疗效。方法:对10例应用诺和灵短效胰岛素联合诺和灵中效胰岛素治疗的1型糖尿病患儿以超短效胰岛素诺和锐等量替代短效胰岛素联合诺和灵中效胰岛素治疗1个月,观察HbA1c等代谢指标变化。结果:用诺和锐治疗后患儿餐后2 h血糖、HbA1c显著下降,P<0．01,平均下降值分别为3．51±1．10 mmol／L与0．64％±0．19％。胰岛素用量与血脂无明显变化,P>0．05。治疗期间未发现明显低血糖。结论:超短效胰岛素诺和锐替代短效胰岛素可进一步控制餐后血糖．并显著降低HbA1c,有利于血糖控制。     

哈西萘德合用654—2治疗冻疮

我们采用哈西萘德乳膏加654—2治疗冻疮40例，疗效满意，随访3年无1例复发。治疗方法：冻疮未溃者用哈西萘德乳膏lOg加654—2片10mg，冻疮已溃者再加氯霉素片0．5g，研碎搅匀，每晚睡前涂患处，同时口服654—2，每日3次，每次lOmg，连服1周。此后每年冬季气温骤降时，再口服654—2，每日3次，每次10mg，连服1周以维持疗效。哈西萘德具有较好的抗炎、抗过敏作用，654—2可解除微血管痉挛，改善微循环，     

脸色腰段椎间盘突出症21例临床分析

胸腰段椎间盘突出症罕见,约占椎间盘突出的0.6％～4％。随着CT及MRI的应用,其发病率有增加的趋势。因其发病率低,报道较少。但由于病变位于脊髓圆椎段,其发病较下腰段椎间盘突出有很大的特殊性,故有必要结合我院近年收治的21例对其作一回顾性分析。1 临床资料