1例喉癌术后并发症的发现与护理

患者，男，54岁，因喉部异物感3个月，声音嘶哑半月余来院就诊，喉部检查发现右侧声带下方有菜花样赘生物，取活体组织检查为喉部中分化鳞癌。患者平素体质好，无消化道及其他病史。于2003年9月18日上午在全麻下行气管切开、半喉切除及右侧淋巴结清扫术，手术过程顺利，失血约200mL，给予输血400mL。手术过程5h，患者留置胃管，安返病房。术后患者清醒，伤口处有少量渗血，     

EXPRESSION OF PCNA, AKP AND ACP DURING DEVELOPMENT OF MOUSE FORE STOMACH CARCINOMA

Objective： To find out the relationship of the expressions of proliferating cell nuclear antigen （proliferating cell nuclear antigen, PCNA）, alkaline phosphotase （alkaline phosphotase, AKP） and acid phosphotase （acid phosphotase, ACP） with the development of mouse fore stomach cancerization. Methods： The animal models, including the various stages during the development of NIH mouse fore stomach carcinoma, were made by N-Nitrososarcosineethylester （N-Nitrososarcosineethylester, NSEE）. The mice were sacrificed on the 14th, 28th, 42nd, 56th, 70th and 84th days respectively after mice were irrigated with NSEE. The fore stomach was taken out and dissected. The methods of histopathology, immunohistochemistry and isoenzyme electrophoresis were adopted to study the dynamic changes of cell shape and expression of PCNA, AKP and ACP. Results： On the 42nd and 56th days after NSEE treatment, the expression of PCNA increased gradually along with the cancerization. Comparing with the control, there were significant differences （P〈0.05）. On the 70th and 84th days, the expression of PCNA increased further （compared with the control P〈0.01）. The activity of AKP increased gradually along with the cancerization. On the 14th, 28th, 42nd and 56th days, there were significant differences （P〈0.05）; on the 70th and 84th days, the activity of AKP increased further （P〈0.01）. The activity of ACP also increased on the 14th, 28th, 42nd and 56th days, and there were significant differences on the 70th days （P〈0.05） and on the 84th days （P〈0.01） compared with the control. Conclusion： During the carcinogenesis of NIH mouse fore stomach, the expressions of PCNA, AKP and ACP increased gradually and were consisted with the changes of cell shapes.     

TRACE ELEMENTS IN HAIR OF TAIHANG MOUNTAIN MONKEYSWITH ESOPHAGEAL PRECANCEROUS LESIONS

Inrecentyears,therehaysbeenmuchresearchdoneonthechangesoftraceelementsinthecanceroustissuesoftheesophagus,stomach,liver,intestines,mammaryglandsandothers,andintheserumofthepatientswithdementiaorepilepsy.l'-ra']However,mostsamplesinthesestudiesweretakenfromthetissuesofcancerouslesionsandtherewasnoreportonthechangesoftraceelementsinesophagealcarcinomaoftheanimalsorinthedevelopmentofcancerouslesions.Inthispaper,weattemptstoseektraceelementsinthecourseofesophagealprecancerouslesionsoftheRhesusbyan…