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鉴于子宫出血与子宫内膜前列腺素(PGs)含量过高或各种PGs之间的比例失调关系密切,近年来,有些人尝试将PG合成酶抑制剂用于子宫出血患者,取得了减少出血量30—50%的效果,提示该病的出血机制似与PGs的含量和比例变化有关。对于子宫内膜的PGF_(2α)和PGE_2的含量,曾有学者进行过研究。随着对PG代谢的研究和深入,花生四稀酸的代谢产物前列腺环素(PGI_2)和血环素A_2(TXA_2)在维持正常血液凝固性中的作用日趋受到重视,前者是目前所知最强的血小板聚集抑制和血管扩张剂,后者则 相似文献
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关于恶性滋养细胞肿瘤,国内外已有较多的报道。我院自1962年7月至1984年12月共收治56例,其中恶性葡萄胎(下称恶葡)32例,绒癌24例,现报道如下。资料分析1.年龄分布:本组发病年龄22至52岁,其中47例(83.93%)在21~35岁。2.妊产次:3胎以内者47例(83.93%),其中第一次妊娠25例。3.前次妊娠情况:恶葡中32例全部发生于本次葡萄胎,24例绒癌中10例(41.67%)来自葡萄胎,6例(25.00%)流产后者,8例(33.33%)足月产后或同时,与国内外文献报道相近。 相似文献
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Using the tetrazolium (MTT) assay, we examined the cytotoxicities of recombinant human tumor necrosis factor (rhTNF) and five chemotherapeutic agents, namely CTX, 5-FU, VCR, DDP and KSM, on human ovarian cancer cell lines OVCAR_3 and CAOV_3. The results showed that the cytotoxicities of rhTNF at concentrations of 50-50000 U / mi on OVCAR_3 cell line and CAOV_3 cell line exposed to rhTNF for 24 hours were from 14.2% ±6.8% to 67.2%± 3.00 and from 8.2%±4.3% to 60.9%±1.3%, respectively. The cytotoxicities of all five chemotherapeutic agents tested on the two cell lines were much lower than that of rhTNF. We also studied the combined antitumor potential of rhTNF with the five chemotherapeutic agents and the results showed that there were various degrees of synergism in cytotoxicities of rhTNF in combination with DDP or KSM on the two cell lines. Based on experiments in vitro, the in vivo antitumor activities of rhTNF, both alone and in combination with KSM, were examined in OVCAR_3 cancer transplanted in 相似文献
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卵巢恶性肿瘤性激素受体的研究已逐渐受到国外学者的注意,但国内尚未见系统报导。本文采用放射性同位素法测定了55例卵巢恶性肿瘤胞浆雌、孕激素受体的含量,并就受体的状态与肿瘤部分临床、病理之间的关系进行了探讨。材料与方法一、研究对象:卵巢恶性肿瘤55人,6~68岁,绝经前27例,绝经后25例,青春期前3例;良性肿瘤12人,16~61岁,绝经前后各6例;正常 相似文献