SPERMIDINE RADIOIMMUNOASSAY IN MONITOR OF PRECANCEROUS LESIONS OF ESOPHAGUS

Serum spermidine was assayed by radioimmuno-assay in different stages of esophageal carcinogenesis in the population from high risk area of esophageal cancer, Linxian County. The serum spermidine values were 76.94 74.38 ng ml in 36 normal individuals; 115.71 113.45 ng/ml in 35 patients with marked epithelial hyperplasia (MEH) and 294.48 135.36 ng/ml in 31 patients with early esophageal cancer. Patients with MEH were given intervention treatment by Aminoretinoic Ester or Anticancer B or placebo (starch) as controls. One year later, samples from the population were collected again for serum spermidine msasurement. The values were 95.8 68.2 ng/ml in 27 normals; 125.1±72.9 ng/ml in 62 patients with MEH treated by Anticancer B; 125.6± 117.2 ng/ml in 64 patients with MEH treated by Aminoretinoic Ester; 162.4±76.6 ng/ml in 62 controls and 210.5±182.9 ng/ml in 44 patients with early esophageal cancer.The results showed that spermidine radioim-munoassay could reflect the tendency of esophageal precancerous     

人血浆皮质醇的放射免疫分析(C~(21)位系统)法的建立及其RIA药箱的研制和C~3位系统皮质醇放射免疫分析法的建立

皮质醇是肾上腺皮质分泌的主要激素之一,皮质醇测定对临床诊断和实验医学均有重要价值。1974年我们在国内首先建立了皮质醇放射免疫分析法,可应用地(125)~Ⅰ、(131)~Ⅱ、3~Ⅱ     

多胺放射免疫测定的研究——III.精脒放射免疫分析法

应用碳二亚胺法将精脒与牛血清白蛋白缩合制成人工抗原,并制得抗精脒抗体,以14C-精脒为示踪物,建成了精脒放射免疫分析法。应用本方法测定正常人16例,平均值为86.6±57.6ng/ml,21例恶性肿瘤患者血清精脒水平明显高于正常人。