全文获取类型
收费全文 | 35912篇 |
免费 | 3187篇 |
国内免费 | 1906篇 |
专业分类
耳鼻咽喉 | 579篇 |
儿科学 | 564篇 |
妇产科学 | 820篇 |
基础医学 | 4213篇 |
口腔科学 | 564篇 |
临床医学 | 4244篇 |
内科学 | 6342篇 |
皮肤病学 | 813篇 |
神经病学 | 1931篇 |
特种医学 | 1208篇 |
外国民族医学 | 17篇 |
外科学 | 3627篇 |
综合类 | 4327篇 |
现状与发展 | 4篇 |
一般理论 | 7篇 |
预防医学 | 2352篇 |
眼科学 | 854篇 |
药学 | 3661篇 |
23篇 | |
中国医学 | 1665篇 |
肿瘤学 | 3190篇 |
出版年
2024年 | 83篇 |
2023年 | 492篇 |
2022年 | 1165篇 |
2021年 | 1546篇 |
2020年 | 1131篇 |
2019年 | 1179篇 |
2018年 | 1295篇 |
2017年 | 1110篇 |
2016年 | 1059篇 |
2015年 | 1582篇 |
2014年 | 1918篇 |
2013年 | 1927篇 |
2012年 | 2696篇 |
2011年 | 2845篇 |
2010年 | 1822篇 |
2009年 | 1365篇 |
2008年 | 1965篇 |
2007年 | 1868篇 |
2006年 | 1888篇 |
2005年 | 1842篇 |
2004年 | 1341篇 |
2003年 | 1276篇 |
2002年 | 1095篇 |
2001年 | 902篇 |
2000年 | 825篇 |
1999年 | 753篇 |
1998年 | 461篇 |
1997年 | 413篇 |
1996年 | 334篇 |
1995年 | 306篇 |
1994年 | 275篇 |
1993年 | 198篇 |
1992年 | 327篇 |
1991年 | 284篇 |
1990年 | 220篇 |
1989年 | 171篇 |
1988年 | 192篇 |
1987年 | 158篇 |
1986年 | 123篇 |
1985年 | 117篇 |
1984年 | 84篇 |
1983年 | 44篇 |
1982年 | 25篇 |
1981年 | 35篇 |
1980年 | 21篇 |
1979年 | 32篇 |
1978年 | 24篇 |
1977年 | 19篇 |
1975年 | 18篇 |
1973年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Her-Shyong Shiah Nai-Jung Chiang Chia-Chi Lin Chia-Jui Yen Hui-Jen Tsai Shang-Yin Wu Wu-Chou Su Kwang-Yu Chang Ching-Chiung Wang Jang-Yang Chang Li-Tzong Chen 《The oncologist》2021,26(4):e567-e579
Lessons Learned
- SCB01A is a novel microtubule inhibitor with vascular disrupting activity.
- This first‐in‐human study demonstrated SCB01A safety, pharmacokinetics, and preliminary antitumor activity.
- SCB01A is safe and well tolerated in patients with advanced solid malignancies with manageable neurotoxicity.
2.
Hyun Jong Choi Jong Ho Moon Yun Nah Lee Hyun Su Kim Ji Su Ha Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park 《Digestive endoscopy》2015,27(7):772-775
Direct peroral cholangioscopy (POC) using an ultra‐slim upper endoscope is one modality of POC for intraductal endoscopic evaluation and treatment of the bile duct. Choledochoduodenostomy (CDS) is one modality of biliary bypass surgery that provides a new route to the bile duct. We carried out direct POC using an ultra‐slim upper endoscope without the use of accessories in 10 patients (four sump syndromes, three bile duct strictures and three intrahepatic duct stones) previously undergoing surgical CDS. Direct POC was successful in all patients. The use of an intraductal balloon catheter was required in one patient for advancement of the endoscope into the bile duct. Distal bile ducts with sump syndromes were cleared using baskets and water irrigation under direct POC. Cholangiocarcinoma was diagnosed in one patient with hilar bile duct stricture after cholangioscopic evaluation and a targeting forceps biopsy under direct POC. Intrahepatic duct stones were successfully extracted after intraductal fragmentation under direct POC. Oozing bleeding occurred during intraductal lithotripsy but stopped spontaneously. Direct POC using an ultra‐slim upper endoscope without the assistance of accessories can easily be carried out in patients undergoing CDS. 相似文献
3.
4.
Yinlei
Wen Huaguang Zhang Hanguang Su He Ren 《Optimal control applications & methods.》2020,41(4):1233-1250
In this article, a model-free off-policy reinforcement learning algorithm is applied to address the optimal tracking problem based on multiplayer non-zero-sum games for discrete-time linear systems. In contrast to the traditional method and the policy iteration method for solving the optimal tracking problems, the proposed algorithm operates with the system data rather than the knowledge of the system dynamics. For performing the proposed algorithm, an auxiliary augmented system is constructed via assembling the original system and the reference trajectory while a discount factor is introduced into the performance indexes. It is analyzed that the solutions of the proposed algorithm converge to the Nash equilibrium and the result is not influenced by the probing noise. Two simulations are presented to verify the feasibility and effectiveness of the proposed algorithm. 相似文献
5.
6.
目的 利用频域光学相干断层扫描深度增强(enhanced depth imaging spectral domain optical coherence tomography,EDI SD-OCT)观察糖尿病黄斑水肿(diabetic macular edema,DME)患者脉络膜厚度(choroidal thickness,CT)的变化及结构特点,探讨DME病变程度与CT的关系。方法 纳入2型糖尿病患者共123例204眼,其中69眼诊断为DME(DME组),135眼无黄斑水肿为对照组。DME眼依据OCT形态学特点进一步分为视网膜弥漫性增厚(diffuse retinal thickness,DRT)型(34眼)、黄斑囊样水肿(cystoid macular edema,CME)型(19眼)和浆液性视网膜脱离(serous retinal detachment,SRD)型(16眼),利用EDI-OCT分别测量黄斑中心凹下CT和以黄斑为中心上、下、鼻、颞500 μm、1000 μm、1500 μm、2000 μm处CT。结果 DME组黄斑中心凹下CT为(326.72±90.15)μm,对照组为(320.17±106.46)μm,两组之间无统计学差异,但黄斑中心凹下CT与视网膜厚度间具有明显正相关关系(r=0.270,P=0.025)。DME亚型CT分别为:DRT型(303.94±81.47)μm、CME型(304.42±73.98)μm和SRD型(401.63±88.80)μm,SRD型CT明显高于其他亚型(P<0.05),此外,SRD型的周边CT同样呈现均匀一致的增厚;鼻侧CT从500 μm至2000 μm呈距离敏感性降低(P<0.05),但SRD型鼻侧CT降低幅度明显变缓(P=0.195)。结论 SRD型黄斑水肿患者CT在中心凹下及周边部均显著增厚,CT与DME病变程度之间有一定相关性。 相似文献
7.
8.
Jianhui Su Chaoyang Ma Chengxiang Liu Chuanzhong Gao Rongjing Nie 《International journal of food sciences and nutrition》2016,67(1):20-28
This study investigated the hypocholesterolaemic effects of bitter melon aqueous extracts (BMAE) in vitro, the inhibitory effects of BMAE on pancreatic cholesterol esterase (CEase) and incorporation of cholesterol into micelles were investigated. BMAE decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. The conformation of CEase was investigated by means of circular dichroism (CD) and fluorescence. The result revealed the decrease of α-helix contents, increase of β-sheet and exposure of aromatic amino acid residuals. The incorporation of cholesterol into micelles was inhibited by BMAE. A complex was observed by transmission electron microscopy (TEM), which indicated interaction between cholesterol and BMAE. The result revealed that BMAE can play a role in decreased intestinal cholesterol absorption via inhibition of CEase, and of micelle formation. 相似文献
9.
10.
Peng‐fei Lei Shi‐long Su Ling‐yu Kong Cheng‐gong Wang Da Zhong Yi‐he Hu 《Orthopaedic Surgery》2019,11(5):914-920
Three‐dimensional (3D) printing technology, virtual reality, and augmented reality technology have been used to help surgeons to complete complex total hip arthroplasty, while their respective shortcomings limit their further application. With the development of technology, mixed reality (MR) technology has been applied to improve the success rate of complicated hip arthroplasty because of its unique advantages. We presented a case of a 59‐year‐old man with an intertrochanteric fracture in the left femur, who had received a prior left hip fusion. After admission to our hospital, a left total hip arthroplasty was performed on the patient using a combination of MR technology and 3D printing technology. Before surgery, 3D reconstruction of a certain bony landmark exposed in the surgical area was first performed. Then a veneer part was designed according to the bony landmark and connected to a reference registration landmark outside the body through a connecting rod. After that, the series of parts were made into a holistic reference registration instrument using 3D printing technology, and the patient's data for bone and surrounding tissue, along with digital 3D information of the reference registration instrument, were imported into the head‐mounted display (HMD). During the operation, the disinfected reference registration instrument was installed on the selected bony landmark, and then the automatic real‐time registration was realized by HMD through recognizing the registration landmark on the reference registration instrument, whereby the patient's virtual bone and other anatomical structures were quickly and accurately superimposed on the real body of the patient. To the best of our knowledge, this is the first report to use MR combined with 3D printing technology in total hip arthroplasty. 相似文献