Hamartomas were first described by Albrecht in 1904, who defined them as tumor-like malformations in which there was abnormal blending of the normal components of an organ. The myoid hamartoma is a rare benign lesion of the breast and has an uncertain origin, possibly in the walls of the blood vessels, muscularis mammillae of the areolae, and mainly in myoepithelium. We report 3 cases of myoid hamartomas of the breast, with the clinical, radiologic, and histopathological findings, and review the literature. The 3 lesions showed normal breast ducts and lobules, entrapped by a muscular stroma and some foci of mature adipose tissue. The muscular origin of part of the stroma was confirmed by strong reactiveness with smooth-muscle actin. 相似文献
BACKGROUND: Data on the efficacy of pimecrolimus cream 1% within the first days of treatment are scarce, as in previous studies, the first postbaseline assessment was performed only after 1 week. OBJECTIVE: We sought to investigate the onset of action of pimecrolimus cream 1% in infants with mild to very severe atopic eczema. METHODS: We used pimecrolimus cream 1% (n = 129) or vehicle cream (n = 66) administered in a double-blind manner for 4 weeks and then open-label pimecrolimus cream 1% for 12 weeks, with a 4-week follow-up period. RESULTS: Pimecrolimus cream 1% reduced the mean Eczema Area and Severity Index at 4 weeks by 71.5% compared with an increase of 19.4% with vehicle ( P < .001). The reduction in the Eczema Area and Severity Index with pimecrolimus cream 1% was significant at day 4 (38.5% vs 17.6% increase with vehicle). Significant improvements in caregivers' assessments of pruritus and sleep loss were observed with pimecrolimus cream 1% by day 2 ( P < .03) and day 3 ( P = .002), respectively, compared with vehicle. Responses to pimecrolimus cream 1% were sustained during the open-label phase, and pimecrolimus cream 1% was well tolerated. Symptoms of atopic eczema returned gradually after discontinuation. CONCLUSION: Pimecrolimus cream 1% was well tolerated and effective in patients with mild to very severe atopic eczema, with rapid onset of action and no disease rebound after discontinuation. 相似文献
Lasers in Medical Science - Knee osteoarthritis (KOA) is a common degenerative disease in which several treatments and treatment associations have been investigated. This review analyzed the... 相似文献
Abnormalities in lungs caused by emphysema might alter their response to sepsis and the occurrence of acute lung injury (ALI). This study compared the extension of ALI in response to intraperitoneal lipopolysaccharide (LPS) injection in Wistar rats with and without emphysema induced by elastase. Adult male Wistar rats were randomized into four groups: control, emphysema without sepsis, normal lung with sepsis and emphysema with sepsis. Sepsis was induced, and 24 h later the rats were euthanised. The following analysis was performed: blood gas measurements, bronchoalveolar lavage (BAL), lung permeability and histology. Animals that received LPS showed significant increase in a lung injury scoring system, inflammatory cells in bronchoalveolar lavage (BAL) and IL‐6, TNF‐α and CXCL2 mRNA expression in lung tissue. Animals with emphysema and sepsis showed increased alveolocapillary membrane permeability, demonstrated by higher BAL/serum albumin ratio. In conclusion, the presence of emphysema induced by elastase increases the inflammatory response in the lungs to a systemic stimulus, represented in this model by the intraperitoneal injection of LPS. 相似文献
The quest for new antiparasitic alternatives has led researchers to base
their studies on insights into biology, host-parasite interactions and pathogenesis.
In this context, proteases and their inhibitors are focused, respectively, as
druggable targets and new therapy alternatives. Herein, we proposed to evaluate the
in vitro effect of the cysteine protease inhibitor E-64 on
Giardia trophozoites growth, adherence and viability.
Trophozoites (105) were exposed to E-64 at different final concentrations,
for 24, 48 and 72 h at 37 °C. In the growth and adherence assays, the number of
trophozoites was estimated microscopically in a haemocytometer, whereas cell
viability was evaluated by a dye-reduction assay using MTT. The E-64 inhibitor showed
effect on growth, adherence and viability of trophozoites, however, its better
performance was detected in the 100 µM-treated cultures. Although metronidazole was
more effective, the E-64 was shown to be able to inhibit growth, adherence and
viability rates by ≥ 50%. These results reveal that E-64 can interfere in some
crucial processes to the parasite survival and they open perspectives for future
investigations in order to confirm the real antigiardial potential of the protease
inhibitors. 相似文献
To analyze the association between the length of napping during the night shift
and the recovery after work among nurses.
METHOD:
Cross-sectional epidemiological study involving 1940 nurses from 18 public
hospitals in the City of Rio de Janeiro. A multidimensional and self-applied
questionnaire was used with information about health, sociodemographic and
occupational characteristics, health-related behaviors and housework. Multiple
logistic regression was applied to identify the association, adjusted for
confounding variables.
RESULTS:
The gross analyses showed 44%, 127% and 66% higher chances of a high level of
recovery after work for nurses who sleep up to two hours, between 2.1 and 3 hours
and 3.1 hours or more, respectively, when compared to the nurses who do not sleep.
After adjusting for confounding variables, the association only continues
significant for the group that sleeps 2.1 to 3 hours during the night shift
(OR=1.79; 95%CI=1.33-2.41).
CONCLUSION:
The association between the length of napping and the high level of recovery
after work, confirmed in the present results, can be included in the studies that
aim to support more appropriate policies aimed at improving the workers'' work,
life and health conditions, not only in nursing, but night-shift workers in
general. 相似文献
The identification of subgroups of obstructive sleep apnea (OSA) is critical to understand disease outcome and treatment response and ultimately develop optimal care strategies customized for each subgroup. In this sense, we aimed to perform a cluster analysis to identify subgroups of individuals with OSA based on clinical parameters in the Epidemiological Sleep Study of São Paulo city (EPISONO). We aimed to analyze whether or not subgroups remain after 8 years, since there is not any evidence showing if these subtypes of clinical presentation of OSA in the same population can change overtime.
Methods
We used data derived from EPISONO cohort, which was followed over 8 years after baseline evaluation. All individuals underwent polysomnography, answered questionnaires, and had their blood collected for biochemical examinations. OSA was defined according to AHI?≥?15 events/h. Cluster analysis was performed using latent class analysis (LCA).
Results
Of the 1042 individuals in the EPISONO cohort, 68% agreed to participate in the follow-up study (n?=?712), and 704 were included in the analysis. We were able to replicate the OSA 3-cluster solution observed in previous studies: disturbed sleep, minimally symptomatic and excessively sleepy in both baseline (36%, 45% and 19%, respectively) and follow-up studies (42%, 43%, and 15%, respectively). The optimal cluster solution for our sample based on Bayesian information criterion (BIC) was 2 cluster for baseline (disturbed sleep and excessively sleepy) and 3 clusters for follow-up (disturbed sleep, minimally symptomatic, and excessively sleepy). A total of 45% of the participants migrated clusters between the two evaluations (and the factor associated with this was a greater delta-AHI (B?=????0.033, df?=?1, p?=?0.003).
Conclusions
The results replicate and confirm previously identified clinical clusters in OSA which remain in the longitudinal analysis, with some percentage of migration between clusters.