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de França Juliane Santos de Sales-Neto José Marreiro Carvalho Deyse Cristina Madruga de Almeida Lima Éssia Olegário Tayná Rodrigues Mendes Rhuan Karlos Santos Lima-Junior Claudio Gabriel de Almeida Vasconcellos Mário Luiz Araújo Rodrigues-Mascarenhas Sandra 《Inflammation》2021,44(3):899-907
Inflammation - Morita-Baylis-Hillman adducts (MBHA) are synthetic molecules with several biological actions already described in the literature. It has been previously described that adduct... 相似文献
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Antônio Luiz Barbosa Pinheiro Nicole Ribeiro Silva Santos Priscila Chagas Oliveira Gilberth Tadeu Santos Aciole Thais Andrade Ramos Tayná Assunção Gonzalez Laís Nogueira da Silva Artur Felipe Santos Barbosa Landulfo Silveira Jr 《Lasers in medical science》2013,28(3):815-822
The aim of the present study was to assess, by Raman spectroscopy and laser fluorescence, the repair of surgical fractures fixed with wire osteosynthesis treated or not with infrared laser (λ780 nm, 50 mW, 4?×?4 J/cm2?=?16 J/cm2, ??=?0.5 cm2, CW) associated or not to the use of hydroxyapatite and guided bone regeneration. Surgical tibial fractures were created under general anesthesia on 15 rabbits that were divided into five groups, maintained on individual cages, at day/night cycle, fed with solid laboratory pelted diet, and had water ad libitum. The fractures in groups II, III, IV, and V were fixed with wires. Animals in groups III and V were grafted with hydroxyapatite (HA) and guided bone regeneration (GBR) technique used. Animals in groups IV and V were irradiated at every other day during 2 weeks (4?×?4 J/cm2, 16 J/cm2?=?112 J/cm2). Observation time was that of 30 days. After animal death, specimens were taken and kept in liquid nitrogen and used for Raman spectroscopy. The Raman results showed basal readings of 1,234.38?±?220. Groups WO?+?B?+?L showed higher readings (1,680.22?±?822) and group WO?+?B the lowest (501.425?±?328). Fluorescence data showed basal readings of 5.83333?±?0.7. Groups WO showed higher readings (6.91667?±?0.9) and group WO?+?B?+?L the lowest (1.66667?±?0.5). There were significant differences between groups on both cases (p?<?0.05). Pearson correlation was negative and significant (R 2 ? =??0.60; p? <?0.001), and it was indicative that, when the Raman peaks of calcium hydroxyapatite (CHA) are increased, the level of fluorescence is reduced. It is concluded that the use of near-infrared lasertherapy associated to HA graft and GBR was effective in improving bone healing on fractured bones as a result of the increasing deposition of CHA measured by Raman spectroscopy and decrease of the organic components as shown by the fluorescence readings. 相似文献
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Passagli Leila Cristina Barros Cota Betania César Simões Taynãna Chama Borges Luz Tatiana 《International journal of clinical pharmacy》2021,43(5):1265-1273
International Journal of Clinical Pharmacy - Background Evidence on patient medication knowledge and associated factors within primary care patients is limited, especially in developing countries.... 相似文献
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Michaël Maes Mitchell R. McGill Tereza Cristina da Silva Margitta Lebofsky Cintia Maria Monteiro de Araújo Taynã Tiburcio 《Toxicology mechanisms and methods》2016,26(2):88-96
Connexin32 is the building block of hepatocellular gap junctions, which control direct intercellular communication and thereby act as goalkeepers of liver homeostasis. This study was set up to investigate whether connexin32 is involved in hepatotoxicity induced by the analgesic and antipyretic drug acetaminophen. To this end, whole body connexin32 knock-out mice were overdosed with acetaminophen followed by sampling at different time points within a 24-h time frame. Evaluation was done based upon a series of clinically and mechanistically relevant read-outs, including protein adduct formation, histopathological examination, measurement of alanine aminotransferase activity, cytokine production, levels of reduced and oxidized glutathione and hepatic protein amounts of proliferating cell nuclear antigen. In essence, it was found that genetic ablation of connexin32 has no influence on several key events in acetaminophen-induced hepatotoxicity, including cell death, inflammation or oxidative stress, yet it does affect production of protein adducts as well as proliferating cell nuclear antigen steady-state protein levels. This outcome is not in line with previous studies, which are contradicting on their own, as both amplification and alleviation of this toxicological process by connexin32 have been described. This could question the suitability of the currently available models and tools to investigate the role of connexin32 in acetaminophen-triggered hepatotoxicity. 相似文献
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Liana de Salles van der Linden Ivan Cunha Bustamante-Filho Ana Paula Binato Souza Tayná Nauê Lopes Anna Flávia Tischer da Silva Luise Marcon Tomé Luis Fernando Macedo Saraiva Timmers Sérgio Ivan dos Santos Adriana Pires Neves 《Andrologia》2020,52(3):e13530
The protein disulphide isomerase A1 (PDIA1) is an important chaperone involved in protein quality control and redox regulation. Also, the ability of PDIA1 to bind to oestrogens suggests that it may play a role in epididymal maturation and male fertility. The goals of this study were to (a) verify the possible interaction between 17β-estradiol and equine PDIA1 using bioinformatics; (b) identify and quantify PDIA1 protein in equine cauda epididymis throughout peripuberty; and (c) determine whether the amounts of PDIA1 in equine seminal plasma and spermatozoa are associated with fertility. Using in silico analysis, we were able to predict the tertiary structure of equine PDIA1 and to demonstrate the interaction between 17β-estradiol and the putative binding site in domains b and b’. Colts under 24 months of age had lower relative amounts of PDIA1 in cauda epididymal fluid in comparison with older males (p < .01). No difference was observed in seminal plasma PDIA1 between fertile and subfertile stallions. Our study demonstrates that PDIA1 expression in the epididymis increases during peripuberty. However, in the adult stallion, its quantity in seminal plasma is not associated with fertility. 相似文献
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