全文获取类型
收费全文 | 678篇 |
免费 | 27篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 34篇 |
妇产科学 | 15篇 |
基础医学 | 80篇 |
口腔科学 | 10篇 |
临床医学 | 64篇 |
内科学 | 152篇 |
皮肤病学 | 11篇 |
神经病学 | 23篇 |
特种医学 | 41篇 |
外科学 | 111篇 |
综合类 | 18篇 |
预防医学 | 26篇 |
眼科学 | 10篇 |
药学 | 48篇 |
中国医学 | 4篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 6篇 |
2022年 | 16篇 |
2021年 | 32篇 |
2020年 | 15篇 |
2019年 | 20篇 |
2018年 | 18篇 |
2017年 | 16篇 |
2016年 | 19篇 |
2015年 | 15篇 |
2014年 | 27篇 |
2013年 | 26篇 |
2012年 | 60篇 |
2011年 | 67篇 |
2010年 | 30篇 |
2009年 | 23篇 |
2008年 | 25篇 |
2007年 | 39篇 |
2006年 | 19篇 |
2005年 | 23篇 |
2004年 | 18篇 |
2003年 | 22篇 |
2002年 | 16篇 |
2001年 | 4篇 |
2000年 | 12篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1996年 | 3篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 12篇 |
1983年 | 18篇 |
1982年 | 10篇 |
1981年 | 4篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1973年 | 4篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1946年 | 1篇 |
1943年 | 1篇 |
1941年 | 1篇 |
排序方式: 共有708条查询结果,搜索用时 15 毫秒
2.
3.
Kalyanam Subramanyam M.D. Weldon G. Kolb M.D. 《The American journal of gastroenterology》1988,83(1):68-70
We report a patient who presented with hematemesis due to ischemic injury to the jejunal segment which had been interposed following distal esophagectomy for a benign esophageal stricture. The complications of this surgery are reviewed. 相似文献
4.
The binding of dapsone, 4,4'-sulfonylbis(aniline)(1), and its diacetylated derivative, 4,4"'-sulfonylbis(acetanilide)(2), to human serum albumin is reported. To assess the ability of these compounds to displace 4'-[(4-aminophenyl)sulfonyl]acetanilide (3) from albumin, a dialysis rate technique was used. Competition for the bilirubin binding site on albumin was measured with the peroxidase assay. Compounds 1 and 2 strongly displaced both 3 and bilirubin from human serum albumin. The association constants for 1 and 2 with respect to bilirubin binding were 1.29 X 10(3) and 1.15 X 10(4) M-1, respectively. These results suggest that the binding site for 3 and the bilirubin binding site are similar with respect to 1 and 2 and that the binding of dapsone and its derivatives probably does not involve the amino function. 相似文献
5.
The COVID-19 pandemic has affected the ability of the sports medicine physician to be present to participate in in-person sideline evaluation of the injured athlete. The purpose of this review is to assess existing literature regarding the utilization of telehealth for sideline evaluation and management of the injured athlete, as well as to identify further areas of research. With the rapid incorporation of telehealth visits, the utilization and capabilities of telemedicine continue to expand. A number of evidence-based resources are available to support medical providers to develop and utilize video evaluation for the sideline evaluation of sports-related injuries. Future research, including the development of validated, modified examination techniques and technologies, will allow for improved interactive physical examinations, which may be better utilized for sideline evaluation. 相似文献
6.
Muhammad Daud Prasad Dasari Marion Adelfinger Daniela Langenhorst Jasmin Lother Dragana Slavkovic-Lukic Carsten Berges Michaela Kruhm Annette Galler Cathrin Schleussner Christian H. Luther Karl Alberter Anton Althammer Haroon Shaikh Niklas Pallmann Jochen Bodem Mohammed El-Mowafy Andreas Beilhack Marcus Dittrich Max S. Topp Peter F. Zipfel Niklas Beyersdorf 《European journal of immunology》2023,53(11):2250284
To obtain a better understanding of the biology behind life-threatening fungal infections caused by Candida albicans, we recently conducted an in silico screening for fungal and host protein interaction partners. We report here that the extracellular domain of human CD4 binds to the moonlighting protein enolase 1 (Eno1) of C. albicans as predicted bioinformatically. By using different anti-CD4 monoclonal antibodies, we determined that C. albicans Eno1 (CaEno1) primarily binds to the extracellular domain 3 of CD4. Functionally, we observed that CaEno1 binding to CD4 activated lymphocyte-specific protein tyrosine kinase (LCK), which was also the case for anti-CD4 monoclonal antibodies tested in parallel. CaEno1 binding to naïve human CD4+ T cells skewed cytokine secretion toward a Th2 profile indicative of poor fungal control. Moreover, CaEno1 inhibited human memory CD4+ T-cell recall responses. Therapeutically, CD4+ T cells transduced with a p41/Crf1-specific T-cell receptor developed for adoptive T-cell therapy were not inhibited by CaEno1 in vitro. Together, the interaction of human CD4+ T cells with CaEno1 modulated host CD4+ T-cell responses in favor of the fungus. Thus, CaEno1 mediates not only immune evasion through its interference with complement regulators but also through the direct modulation of CD4+ T-cell responses. 相似文献
7.
Subramanyam SB 《Indian journal of pediatrics》1996,63(5):641-644
More than 2,500 samples were analyzed and we found 135 abnormal amino acid patients in different categories. The major four
diseases are: Maple syrup urine disease (MSUD), Phenylketonuria (PKU) both classical PKU due to L-phenylalanine hydroxylase
deficiency and 6-pyruvoyl tetrahydropterin synthase (6PTPS) deficiency, homocystinuria and Tyrosinemia. 相似文献
8.
Sathanandam S Anand Subramanyam N Murthy Vishal S Vaidya Moiz M Mumtaz Harihara M Mehendale 《Food and chemical toxicology》2003,41(8):1123-1132
The objective of this study was to evaluate the interaction profile of chloroform (CHCl(3))+allyl alcohol (AA) binary mixture (BM)-induced acute hepatotoxic response. Plasma alanine aminotransferase (ALT) was measured to assess liver injury, and 3H-thymidine (3H-T) incorporation into hepatonuclear DNA was measured as an index of liver regeneration over a time course of 0-72 h. Male Sprague-Dawley (S-D) rats received single ip injection of 5-fold dose range of CHCl(3) (74, 185 and 370 mg/kg) in corn oil (maximum 0.5 ml/kg) and 7-fold dose range of AA (5, 20 and 35 mg/kg) in distilled water simultaneously. The doses for BM were selected from individual toxicity studies of CHCl(3) alone [Int. J. Toxicol. 22 (2003) 25], and AA alone [Reg. Pharmacol. Toxicol. 19 (1999) 165]. Since the highest dose of each treatment (CHCl(3)- 740 and AA- 50 mg/kg) yielded mortality due to the suppressed tissue repair followed by liver failure, this dose was omitted for BM. The levels of CHCl(3) (30-360 min) and AA (5-60 min) were quantified in blood and liver by gas chromatography (GC). The liver injury was more than additive after BM compared to CHCl(3) alone or AA alone at highest dose combination (370+35 mg/kg), which peaked at 24 h. The augmented liver injury observed with BM was consistent with the quantitation data. Though the liver injury was higher, the greater stimulation of tissue repair kept injury from progressing, and rescued the rats from hepatic failure and death. At lower dose combinations, the liver injury was no more than additive. Results of the present study suggest that liver tissue repair, in which liver tissue lost to injury is promptly replaced, plays a pivotal role in the final outcome of liver injury after exposure to BM of CHCl(3) and AA. 相似文献
9.
Subramanyam S Yurkovetsiky A Hale D Sawan SP 《Journal of endourology / Endourological Society》2000,14(1):43-48
Contact biocides are a relatively new form of infection-resistant materials. Surfacine is a silver based antimicrobial coating that can be immobilized on the surface of most alloplastic materials used to fabricate devices. It exhibits broad-spectrum antimicrobial activity exclusively at the surface without elution and does not induce antimicrobial activity in contacting fluids such as urine regardless of volume. Because it is permanently immobilized on the material surface, the coating is nontoxic to cells and is not anticipated to exhibit immunogenicity, teratogenicity, or carcinogenicity. 相似文献
10.