Serum IgE elevation with tropical eosinophilia

Sera from thirteen patients with tropical eosinophilia had IgE levels of 7000–56,000 μ/ml, unrelated to the level of eosinophilia or the duration of symptoms. They are the richest source of polyclonal IgE we have encountered.     

Pilo-sebaceous duct physiology

We have used surface microscopy to measure the pil-sebaceous duct orifices at different sites in 150 subjects. Our data have shown that there are more pilo-sebaceous units on the face compared to the back and that these exists are smaller on the face. Despite the small exit the sebum excretion rate per gland on the forehead was not significantly different from that on the back. Thus the number of pilo-sebaceous duct units and the pilo-sebaceous canal exit size are possible factors in the localization of acne.     

The Concurrent Use of Alcohol, Cigarettes and Caffeine in British Benzodiazepine Users as Measured by a General Population Survey

A 1985 general population survey was conducted by Gallup in Great Britain. Subjects (4,148) were questioned about their use of benzodiazepines of whom 1,284 were also questioned about their alcohol, cigarette and caffeine consumption. Data were examined to find possible multiple substance misuse. No strong evidence could be found. People taking benozodiazepines at the time of the survey consumed significantly less alcohol than non-users or past users. Cigarette consumption was found to be increased in current and past benzodiazepine users. Subgroups of benzodiazepine users, defined as‘high users’,‘dosage escalators’or‘chronic users’were also examined. Again no strong evidence of multiple substance misuse could be found. However, high users and dosage escalators did smoke more than others. Concurrent misuse of benzodiazepines and other legally available psychoactive substances is not common in the general population.     

益肾蠲痹丸对类风湿性关节炎的药效学研究

目的：使用弗氏完全佐剂制作大鼠关节炎模型,评价益’肾蠲痹丸对类风湿性关节炎的药效。方法：使用弗氏完全佐剂造模后,测量益肾蠲痹丸对对侧足爪肿胀和脏器指数的影响：ELISA法检测其对血清肿瘤坏死因子Ⅱ（TNF-Ⅱ）,白介素1β（IL—1β）,白介素-6（IL-6）的影响;分光光度法测量总一氧化氮合酶（tNOS）和诱导型一氧化氮合酶（iNOS）活性：并用Westernblot法检测益肾蠲痹丸对凋亡蛋白Bcl-2表达的影响。结果：益肾蠲痹丸可有效抑制大鼠佐剂性关节炎所引起的足跖肿胀,且对胸腺脾脏指数无明显影响。益肾蠲痹丸可有效抑制血清中TNF-Ⅱ,IL-1β,IL-6含量：抑制血清中iNOS活性;下调Bcl-2在滑膜组织中的表达。结论：益肾蠲痹丸的抗类风湿关节炎的作用与其调节主要炎症因子,下调炎症部位Bcl-2蛋白表达有关。     

2. THE EFFECT OF KERATIN HYDRATION ON SEBUM EXCRETION RATE Pilo-sebaceous duct physiology

Sebum excretion rate was measured before and after occlusions of the skin in eleven subjects. The sebum excretion rate rose significantly following occlusion, confirming the view that there is an obstruction to the outflow of sebum with keratin hydration.