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Bethany G. Elkington Kongmany Sydara Andrew Newsome Chang Hwa Hwang David C. Lankin Charlotte Simmler José G. Napolitano Richard Ree James G. Graham Charlotte Gyllenhaal Somsanith Bouamanivong Onevilay Souliya Guido F. Pauli Scott G. Franzblau Djaja Djendoel Soejarto 《Journal of ethnopharmacology》2014
Ethnopharmacological relevance
There is widespread use of traditional herbal remedies in the Lao PDR (Laos). It is common practice to treat many diseases with local plants. This research project documented and analysed some of these traditional remedies used to treat symptoms of tuberculosis (TB).Materials and methods
This research was executed by interviewing healers about plants used traditionally to treat the symptoms of TB. Samples of some of the plants were collected, and extracts of 77 species were submitted to various in vitro assays in order to determine the amount of growth inhibition of virulent Mycobacterium tuberculosis H37Rv (Mtb), as opposed to other microbes and mammalian Vero cells.Results
Interviews took place with 58 contemporary healers in 5 different provinces about plants currently used, giving a list of 341 plants. Bioassay-guided fractionation was performed on Marsypopetalum modestum (Pierre) B. Xue and R.M.K. Saunders (Annonaceae), leading to the isolation of dipyrithione, an anti-mycobacterial compound isolated for the first time from the genus Marsypopetalum through this research.Conclusions
This research has helped to increase awareness of Laos’ rich diversity of medicinal plants and will hopefully provide incentive to preserve the undeveloped forested areas that remain, which still hold a wealth of medical information for future discoveries. 相似文献
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