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1.
Ketut Indra Djaja P 《中国医学文摘:肿瘤学》2007,21(2):152-154
在生物体内如果过氧化物的产生和消除存在不平衡均会导致氧化应激的发生.很多病理生理状况跟氧化应激有密切的关系。氧化应激产生的活性氧.可诱发DNA碱基发生化学修饰,在嘌呤残基的C-8位置和DNA整合,形成8-羟基二羟鸟嘌呤并进-步氧化形成8-羟基鸟嘌呤(8-OHdG)。8-OHdG是一种主要的DNA氧化损伤产物,经碱基切除修复通路来完成修复,若不及时修复,则参与癌变的发生。 相似文献
2.
Jones WP Lobo-Echeverri T Mi Q Chai H Lee D Soejarto DD Cordell GA Pezzuto JM Swanson SM Kinghorn AD 《The Journal of pharmacy and pharmacology》2005,57(9):1101-1108
As part of an ongoing collaborative effort to discover new anticancer agents from plants, an extract obtained from the leaves and twigs of Avicennia germinans, collected in a coastal area of southern Florida, was identified as possessing cytotoxic activity in a panel of human cancer cell lines. Fractionation of the petroleum ether partition, using cytotoxicity to guide the fractionation, led to the isolation of 3-chlorodeoxylapachol. The antitumour potential of 3-chlorodeoxylapachol was demonstrated with the in-vivo hollow fibre assay, a model of antitumour activity using human cancer cell-filled fibres implanted into mice. The possibility that this compound is an artefact of the isolation procedure was ruled out by liquid chromatography-mass spectrometry analysis of extracts prepared without the use of chlorinated solvent. In conclusion, 3-chlordeoxylapachol, a secondary metabolite obtained from the chloroform-soluble extract of a mangrove tree, was cytotoxic in a panel of human cancer cells, and active against KB human cancer cells in the murine hollow fibre antitumour model, with selectivity in KB cells for the intravenous site at lower doses, indicating possible metabolic activation. 相似文献
3.
New Sesquiterpenes from Litsea verticillata 总被引:3,自引:0,他引:3
Zhang HJ Tan GT Santarsiero BD Mesecar AD Hung NV Cuong NM Doel Soejarto D Pezzuto JM Fong HH 《Journal of natural products》2003,66(5):609-615
Seven new sesquiterpenes, named litseagermacrane (1), 7-epi-eudesm-4(15)-ene-1alpha,6alpha-diol (2), 5-epi-eudesm-4(15)-ene-1beta,6beta-diol (4), litseahumulanes A (6) and B (7), and litseachromolaevanes A (11) and B (12), as well as the known compounds 7-epi-eudesm-4(15)-ene-1beta,6beta-diol (3), eudesm-4(15)-ene-1beta,6alpha-diol (5), octahydro-4-hydroxy-3alpha-methyl-7-methylene-alpha-(1-methylethyl)-1H-indene-1-methanol (8), 10-hydroxyl-15-oxo-alpha-cadinol (9), and aphanamol II (10), were isolated from an anti-HIV fraction of the leaves and twigs of Litsea verticillata Hance (Figure 1). Isolates 1, 4, and 12 were found to inhibit HIV-1 replication in a green fluorescent protein (GFP)-based reporter cell line (HOG.R5) with IC(50) values of 6.5 (27.5), 17.4 (73.1), and 28.0 (119.7) microg/mL (microM), respectively. The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra. Compound 11 was confirmed by X-ray crystallographic analysis. 相似文献
4.
5.
Jones WP Lobo-Echeverri T Mi Q Chai HB Soejarto DD Cordell GA Swanson SM Kinghorn AD 《Journal of natural products》2007,70(3):372-377
Bioassay-guided fractionation of the combined fruits, leaves, and twigs (fruiting branches) of Callicarpa americana, collected from a plot in a forested area in southern Florida, led to the isolation of six new clerodane diterpenes (1-6) and eight known compounds. The structures of 1-6 [12(S),16xi-dihydroxycleroda-3,13-dien-15,16-olide (1), 12(S)-hydroxy-16xi-methoxycleroda-3,13-dien-15,16-olide (2), 12(S)-hydroxycleroda-3,13-dien-15,16-olide (3), 16xi-hydroxycleroda-3,11(E),13-trien-15,16-olide (4), 3beta,12(S)-dihydroxycleroda-4(18),13-dien-15,16-olide (5), and 12(S)-hydroxycleroda-3,13-dien-16,15-olide (6)] were elucidated by interpretation of spectroscopic data and chemical methods. The absolute configuration at C-12 in 1 and 3 was ascertained using the Mosher ester technique. The cytotoxicity of all isolates was tested against a panel of human cancer cell lines, and compounds 1, 4, and 6, and the known compounds genkwanin, 16xi-hydroxycleroda-3,13-dien-15,16-olide, and 2-formyl-16xi-hydroxy-3-A-norcleroda-2,13-dien-15,16-olide were active (ED50 <5 microg/mL). However, 1 was found to be inactive against human cancer cells implanted in mice using a hollow-fiber tumor model. 相似文献
6.
V Singhasivanon T Chongsuphajaisiddhi A Sabcharoen P Attanath H K Webster W H Wernsdorfer U K Sheth I Djaja Lika 《European journal of drug metabolism and pharmacokinetics》1992,17(4):275-279
The study was carried out in 12 children aged 6 months to 2 years, with uncomplicated falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok. They were treated with mefloquine in the form of MSP (mefloquine 250 mg+sulfadoxine 500 mg+pyrimethamine 25 mg) at a single dose of 25 mg mefloquine base/kg body weight. All of them were cured (28 days follow-up) with minimal side effects. Pharmacokinetic parameter determination was carried out in 9 cases. The results revealed that MRT, t1/2 and tmax in this study (children 6-24 months old) are comparable to the values in children aged 5-12 years, but shorter than in adult patients. Cmax and AUC in children 6-24 months old are comparable to those in children of 5-12 years, but much higher than in adult patients. Vz/f values in this study are comparable to those in children 5-12 years old, but lower than in adult patients. 相似文献
7.
N Kaneda J M Pezzuto D D Soejarto A D Kinghorn N R Farnsworth T Santisuk P Tuchinda J Udchachon V Reutrakul 《Journal of natural products》1991,54(1):196-206
From a cytotoxic Et2O-soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1-7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1-12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on 1H-1H COSY, 1H-13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines. 相似文献
8.
Z B Tu C Konno D D Soejarto D P Waller A S Bingel R J Molyneux J A Edgar G A Cordell H H Fong 《Journal of pharmaceutical sciences》1988,77(5):461-463
The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1-10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract. No antifertility effects were seen in MeOH extract-treated hamsters. 相似文献
9.
Libman A Bouamanivong S Southavong B Sydara K Soejarto DD 《Journal of ethnopharmacology》2006,106(3):303-311
A field survey of commonly used medicinal plants in the district of Paksan, Bolikhamsai Province in the Lao People's Democratic Republic (Lao P.D.R.) indicates that 55 species of plants, belonging to 49 genera in 31 families of vascular plants, are used in day-to-day medical therapy. Lao names along with uses and preparations for remedies are given. Seven species have medicinal uses that overlap with uses reported in the literature. No medicinal uses have been previously reported for 31 of the species collected based on ethnobotanical field interviews, signifying that their uses may be unique to Laos. Nine of the 31 previously unreported species are mentioned as medicinals multiple times, indicating that further research may be warranted. 相似文献
10.
Nun TK Kroll DJ Oberlies NH Soejarto DD Case RJ Piskaut P Matainaho T Hilscher C Wang L Dittmer DP Gao SJ Damania B 《Molecular cancer therapeutics》2007,6(8):2360-2370
Tumors associated with Kaposi's sarcoma-associated herpesvirus infection include Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Virtually all of the tumor cells in these cancers are latently infected and dependent on the virus for survival. Latent viral proteins maintain the viral genome and are required for tumorigenesis. Current prevention and treatment strategies are limited because they fail to specifically target the latent form of the virus, which can persist for the lifetime of the host. Thus, targeting latent viral proteins may prove to be an important therapeutic modality for existing tumors as well as in tumor prevention by reducing latent virus load. Here, we describe a novel fluorescence-based screening assay to monitor the maintenance of the Kaposi's sarcoma-associated herpesvirus genome in B lymphocyte cell lines and to identify compounds that induce its loss, resulting in tumor cell death. 相似文献