全文获取类型
收费全文 | 47篇 |
免费 | 4篇 |
专业分类
儿科学 | 4篇 |
基础医学 | 6篇 |
口腔科学 | 4篇 |
临床医学 | 6篇 |
内科学 | 12篇 |
神经病学 | 5篇 |
外科学 | 3篇 |
预防医学 | 1篇 |
眼科学 | 1篇 |
药学 | 5篇 |
中国医学 | 2篇 |
肿瘤学 | 2篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2019年 | 1篇 |
2017年 | 3篇 |
2014年 | 2篇 |
2013年 | 2篇 |
2011年 | 6篇 |
2010年 | 4篇 |
2009年 | 3篇 |
2008年 | 1篇 |
2007年 | 3篇 |
2006年 | 3篇 |
2005年 | 9篇 |
2004年 | 3篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1994年 | 1篇 |
1989年 | 1篇 |
排序方式: 共有51条查询结果,搜索用时 15 毫秒
1.
2.
There are several receptors capable of inducing activating generator potentials in cough-associated afferent terminals in the airways. The chemical receptors leading to generator potentials can be subclassified into ionotropic and metabotropic types. An ionotropic receptor has an agonist-binding domain, and also serves directly as an ion channel that is opened upon binding of the agonist. Examples of ionotropic receptors found in airway sensory nerve terminals include receptors for serotonin (5-HT3 receptors), ATP (P2X receptors), acetylcholine (nicotinic receptors), receptors for capsaicin and related vanilloids (TRPV1 receptors), and acid receptors (acid sensing ion channels). Afferent nerve terminals can also be depolarized via activation of metabotropic or G-protein coupled receptors (GPCRs). Among the GPCRs that can lead to activation of airway afferent fibers include bradykinin B2 and adenosine A1 receptors. The signaling events leading to GPCR-mediated membrane depolarization are more complex than that seen with ionotropic receptors. The GPCR-mediated effects are thought to occur through classical second messenger systems such as activation of phospholipase C. This may lead to membrane depolarization through interaction with specific ionotropic receptors (such as TRPV1) and/or various types of calcium activated channels. 相似文献
3.
Chittrakarn S Sawangjaroen K Prasettho S Janchawee B Keawpradub N 《Journal of ethnopharmacology》2008,116(1):173-178
Kratom (Mitragyna speciosa Korth.) is an indigenous plant of Thailand used traditionally in folk medicine although it is claimed to cause addiction. It is used to treat diarrhea, however, there is no scientific evidence to support the use. The aim of this study is to investigate the effect of methanolic extract of kratom leaves on the rat gastrointestinal tract. Kratom extract at 50, 100, 200 and 400 mg/kg (p.o.) caused a dose dependent protection against castor oil-induced diarrhea in rats and also inhibited intestinal transit. The antidiarrheal effect was not antagonized by naloxzone. The inhibition of intestinal transit by kratom extract was significantly different from the control when treated with a single dose for 1 day. For longer-term treatments of 15 and 30 days, kratom extract did not decrease the intestinal transit time indicating that adaptation had occurred. Kratom extract at a dose level of 200 and 400 mg/kg for 30 days and morphine at 3 mg/kg (i.p.) caused a decrease in the increment of body weight that was significantly different from the control and kratom extract at lower doses (50 and 100 mg/kg). However it had no effect on the level of plasma cholecystokinin. The results suggested that methanolic kratom extract exhibited its antidiarrheal effect on rat gastrointestinal tract. The effects may occur via pathways in addition to the action on opioid receptors. High does of kratom extract decreased the increment of body weight similar to the effect of morphine. 相似文献
4.
Vichai Laosombat Vip Viprakasit Thirachit Chotsampancharoen Malai Wongchanchailert Sudarat Khodchawan Worawut Chinchang Benjamas Sattayasevana 《Annals of hematology》2009,88(12):1185-1192
We studied the α-globin gene abnormalities, the clinical features, hematologic values, growth assessment, transfusion therapy,
and serum ferritin levels of patients with hemoglobin H (HbH) disease in southern Thailand. HbH disease in 83 of the 147 patients
was the deletional type of HbH. The remaining 64 patients was the nondeletional type of HbH disease. All 83 patients with
the deletional type were double heterozygotes of α0-thalassemia and α+-thalassemia. The Southeast Asian type of α0-thalassemia accounted for 98% of the Thai patients with HbH disease and the Thai type of α0-thalassemia made up the rest. A 3.7-kb deletion accounted for 91% of α+-thalassemia, and a 4.2-kb deletion made up the rest of the deletional type. In patients with nondeletional type of HbH disease,
the Constant Spring variant was the majority of the disease. Newborns with a nondeletional genotype had higher mean corpuscular
volume, had higher mean corpuscular hemoglobin, had higher red blood cell distribution width, had lower mean corpuscular hemoglobin
concentration, and had higher proportions of Hb Bart's than those with a deletional genotype. Twenty-one percent of children
with HbH disease had growth deficiency. A genotype–phenotype correlation was found; patients with the nondeletional type of
HbH disease had more symptoms at a younger age, more severe hemolytic anemia, more growth deficiency, more dysmorphic facial
features, larger spleens, larger livers, and higher serum ferritin levels and required more transfusions than patients with
deletional HbH disease. 相似文献
5.
6.
7.
8.
9.
In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis 下载免费PDF全文
Hongmanee P Rukseree K Buabut B Somsri B Palittapongarnpim P 《Antimicrobial agents and chemotherapy》2007,51(3):1105-1106
The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates. 相似文献