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An ion selective electrode for chlorpheniramine (CP) was studied. The PVC(polyvinyl chloride)matrix membrane was prepared by the CP-tetraphenylborate salt, dibutyl phthalate and 10% PVC-tetrahydrofuran solution in weight ratio of 0.007:0.69:3.0. The CP ion electrode shows Nernstian range from 1×10-2 to 1×10-5M in the pH range of 5~7, with an average slope of 56.0±0.1 mV/decade. Paracetamol (4-acetamidophenol), aminopyrine, caffeine, moroxydine, sodium benzoate etc do not interfere, whereas phenergan (promethazine) ion interferes. The electrode is useful as an indicator for the precipitation titration of CP and some of its preparations with sodium tetraphenylborate. 相似文献
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扑尔敏是当前重要的抗组织胺药物,广泛用于临床,其含量测定各国药典多采用非水滴定法,此法虽简便,但不适于制剂特别是复方制剂的测定。扑尔敏制剂的分析方法,文献报道有分光光度法、气相色谱法、比色法、间接络合量法,大多手续繁琐。药 相似文献
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